Results 101 to 110 of about 52,982 (243)

Selective Effects of Acutely Administered N‐Acetyl‐Cysteine in Rodent Models of Nicotine‐Conditioned Behaviours

Addiction Biology, Volume 30, Issue 9, September 2025.
ABSTRACT Chronic nicotine administration leads to neuroadaptations, an important process in nicotine and tobacco dependence for which treatments are limited. The cysteine pro‐drug, N‐acetyl‐cysteine (NAC), is a promising glutamatergic agent that has shown some clinical efficacy in reducing nicotine use in humans.
Kelsey Stoddart, Michael Davies, Jamie Oughton, Emma Malcolm, Shakir D. AlSharari, Mohammed Shoaib   +5 more
wiley   +1 more source

Grape seed proanthocyanidin extract inhibits glutamate-induced cell death through inhibition of calcium signals and nitric oxide formation in cultured rat hippocampal neurons

BMC Neuroscience, 2011
Background Proanthocyanidin is a polyphenolic bioflavonoid with known antioxidant activity. Some flavonoids have a modulatory effect on [Ca2+]i. Although proanthocyanidin extract from blueberries reportedly affects Ca2+ buffering capacity, there are no ...
Kim Myung-Jun, Hong Yi, Jeong Imju, Kim Hee, Ahn Seo-Hee, Rhie Duck-Joo, Jo Yang-Hyeok, Hahn Sang, Yoon Shin   +8 more
doaj   +1 more source

Clozapine Normalizes a Glutamatergic Transmission Abnormality Induced by an Impaired NMDA Receptor in the Thalamocortical Pathway via the Activation of a Group III Metabotropic Glutamate Receptor

Biomolecules, 2019
Pharmacological mechanisms of gold-standard antipsychotics against treatment-refractory schizophrenia, such as clozapine (CLZ), remain unclear. We aimed to explore the mechanisms of CLZ by investigating the effects of MK801 and CLZ on tripartite synaptic
K. Fukuyama, Ryo Kato, M. Murata, T. Shiroyama, M. Okada   +4 more
semanticscholar   +1 more source

Developing HaloTag and SNAP‐Tag Chemical Inducers of Dimerization to Probe Receptor Oligomerization and Downstream Signaling

Angewandte Chemie International Edition, Volume 64, Issue 35, August 25, 2025.
Controlling protein interactions is key to studying signaling. Antibody methods have limits, but chemical inducers of dimerization (CIDs) using HaloTags and SNAP‐Tags offer precise control. We present CIDs to covalently link heteromers with varied linkers and a FRET‐based sensor.
Michael Trumpp, Blaise Gatin‐Fraudet, Kjell Bruckmann, Wiktor Burdzinski, Kilian Roßmann, Joshua Levitz, Petra Knaus, Jerome Jatzlau, Johannes Broichhagen   +8 more
wiley   +1 more source

Design, Synthesis, and Characterization of [¹⁸F]mG2P026 as a High-Contrast PET Imaging Ligand for Metabotropic Glutamate Receptor 2. [PDF]

J Med Chem, 2022
Yuan G, Dhaynaut M, Guehl NJ, Afshar S, Huynh D, Moon SH, Iyengar SM, Jain MK, Pickett JE, Kang HJ, Ondrechen MJ, El Fakhri G, Normandin MD, Brownell AL.   +13 more
europepmc   +1 more source

Metabotropic Glutamate 2 Receptors Modulate Synaptic Inputs and Calcium Signals in Striatal Cholinergic Interneurons [PDF]

, 2002
Antonio Pisani, Paola Bonsi, Maria Vincenza Catania, Rosario Giuffrida, Michele Morari, Matteo Marti, Diego Centonze, Giorgio Bernardi, Ann E. Kingston, Paolo Calabresi   +9 more
openalex   +1 more source

Aberrant Modular Dynamics of Functional Networks in Schizophrenia and Their Relationship With Neurotransmitter and Gene Expression Profiles

Human Brain Mapping, Volume 46, Issue 12, 15 August 2025.
By harmonizing resting‐state fMRI data from a relatively large multi‐site sample, this study reveals altered modular dynamics in schizophrenia. These alterations are associated with multiple neurotransmitter systems and transcriptomic profiles that are preferentially enriched for biological processes of transmembrane transport and brain development, as
Yi Zhen, Yaqian Yang, Yi Zheng, Zhiming Zheng, Hongwei Zheng, Shaoting Tang   +5 more
wiley   +1 more source

Synthesis and Characterization of [¹⁸F]JNJ-46356479 as the First ¹⁸F-Labeled PET Imaging Ligand for Metabotropic Glutamate Receptor 2. [PDF]

Mol Imaging Biol, 2021
Yuan G, Guehl NJ, Zheng B, Qu X, Moon SH, Dhaynaut M, Shoup TM, Afshar S, Kang HJ, Zhang Z, El Fakhri G, Normandin MD, Brownell AL.   +12 more
europepmc   +1 more source

Metabotropic Glutamate Receptor 5 Upregulation in A-Fibers after Spinal Nerve Injury: 2-Methyl-6-(Phenylethynyl)-Pyridine (MPEP) Reverses the Induced Thermal Hyperalgesia [PDF]

, 2002
Lindsey Hudson, Stuart Bevan, Kara McNair, Clive Gentry, Alyson Fox, Rainer Kühn, Janet Winter   +6 more
openalex   +1 more source

Could MDMA Promote Stemness Characteristics in Mouse Embryonic Stem Cells via mGlu5 Metabotropic Glutamate Receptors? [PDF]

Cell Journal, 2012
Objective: Ecstasy, or 3, 4 (±) methylenedioxymethamphetamine (MDMA), is a potent neurotoxic drug. One of the mechanisms for its toxicity is the secondary release of glutamate.
Rokhsareh Meamar, Fereshte Karamali, Seyed Ali Mousavi, Hossein Baharvand, Mohammad Hossein Nasr-Esfahani   +4 more
doaj