Results 151 to 160 of about 79,817 (291)

Tet controls axon guidance in early brain development through glutamatergic signaling

iScience
Summary: Mutations in ten-eleven translocation (TET) proteins are associated with human neurodevelopmental disorders. We find a function of Tet in regulating Drosophila early brain development.
Hiep Tran, Le Le, Badri Nath Singh, Joseph Kramer, Ruth Steward   +4 more
doaj   +1 more source

Pituitary Adenylate Cyclase-Activating Polypeptide Orchestrates Neuronal Regulation Of The Astrocytic Glutamate-Releasing Mechanism System x\u3csub\u3ec\u3c/sub\u3e\u3csup\u3e−\u3c/sup\u3e [PDF]

, 2016
Glutamate signaling is achieved by an elaborate network involving neurons and astrocytes. Hence, it is critical to better understand how neurons and astrocytes interact to coordinate the cellular regulation of glutamate signaling.
Albano, Rebecca, Baker, David A., Choi, Sujean, Kong, Linghai, Lobner, Doug, Madayag, Aric, Mantsch, John R., Raddatz, Nicholas   +7 more
core   +1 more source

Increased Metabotropic Glutamate 2/3 Receptor Binding in the Perigenual Anterior Cingulate Cortex of Cloninger Type 2 Alcoholics: A Whole-Hemisphere Autoradiography Study [PDF]

, 2014
Virpi Laukkanen, Olli Kärkkäinen, Jukka Kupila, Hannu Kautiainen, Jari Tiihonen, Markus Storvik   +5 more
openalex   +1 more source

Development of Potent and Selective Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 2 for the Potential Treatment of Alzheimer’s Disease [PDF]

, 2023
Jeremy S. Coleman, Rory A. Capstick, Upendra Rathnayake, Lauren C. Parr, Sichen Chang, Analisa D. Thompson, Aidong Qi, Colleen M. Niswender, Olivier Boutaud, Hyekyung Plumley, Carrie K. Jones, Darren W. Engers, Craig W. Lindsley   +12 more
openalex   +1 more source

A PI3K-mediated negative feedback regulates Drosophila motor neuron excitability [PDF]

, 2008
Negative feedback can act as a homeostatic mechanism to maintain neuronal activity at a particular specified value. At the Drosophila neuromuscular junction, a mutation in the type II metabotropic glutamate receptor gene (mGluRA) increased motor neuron ...
Curtis C. J. Lin, Eric Howlett, Michael Stern, William Lavery   +3 more
core   +1 more source

Synthesis, Pharmacological Characterization, and Molecular Modeling of Heterobicyclic Amino Acids Related to (+)-2-Aminobicyclo[3.1.0]hexane- 2,6-dicarboxylic Acid (LY354740):  Identification of Two New Potent, Selective, and Systemically Active Agonists for Group II Metabotropic Glutamate Receptors

, 1999
James A. Monn, Matthew J. Valli, Steven M. Massey, Marvin M. Hansen, Thomas Kress, James P. Wepsiec, Allen R. Harkness, John L. Grutsch, Rebecca A. Wright, Bryan G. Johnson, Sherri L. Andis, Ann E. Kingston, Rosemarie Tomlinson, Richard A. Lewis, Kelly R. Griffey, Joseph P. Tizzano, Darryle D. Schoepp   +16 more
openalex   +1 more source

Phosphorylation-independent Regulation of Metabotropic Glutamate Receptor 5 Desensitization and Internalization by G Protein-coupled Receptor Kinase 2 in Neurons [PDF]

, 2009
Fabíola M. Ribeiro, Lucimar T. Ferreira, Maryse Paquet, Tamara Cregan, Qingming Ding, Robert Gros, Stephen S. G. Ferguson   +6 more
openalex   +1 more source

G-protein activation by a metabotropic glutamate receptor

Nature, 2021
A. B. Seven, X. Barros-Álvarez, Marine de Lapeyrière, M. Papasergi-Scott, M. J. Robertson, Chensong Zhang, Robert M Nwokonko, Yang Gao, J. Meyerowitz, J. Rocher, Dominik W. Schelshorn, B. Kobilka, J. M. Mathiesen, G. Skiniotis   +13 more
semanticscholar   +1 more source

Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity

, 2016
Mark D. Chappell, Renhua Li, Stephon C. Smith, Bruce A. Dressman, Eric G. Tromiczak, Allie E. Tripp, María‐Jesús Blanco, Tatiana Vetman, Steven J. Quimby, James E. Matt, Thomas C. Britton, Adam M. Fivush, Jeffrey M. Schkeryantz, Daniel Mayhugh, Jon A. Erickson, Mark G. Bures, Carlos Jaramillo, Mercedes Carpintero, J. Eugenio de Diego, Mario Barberis, Susana Garcı́a-Cerrada, José F. Soriano, Stephen Antonysamy, S. Atwell, Iain MacEwan, Bradley Condon, Christine Sougias, Jing Wang, Aiping Zhang, K. Conners, C. Groshong, Stephen R. Wasserman, J. Koss, Jeffrey M. Witkin, Xia Li, C. Overshiner, Keith A. Wafford, Wesley F. Seidel, Xu-Shan Wang, Beverly A. Heinz, Steven Swanson, John T. Catlow, David W. Bedwell, James A. Monn, Charles H. Mitch, Paul L. Ornstein   +45 more
openalex   +2 more sources

SAR study of a subtype selective allosteric potentiator of metabotropic glutamate 2 receptor, N-(4-phenoxyphenyl)-N-(3-pyridinylmethyl)ethanesulfonamide

, 2004
David A. Barda, Zhaoqing Wang, Thomas C. Britton, Steven S. Henry, G. Erik Jagdmann, Darrell S. Coleman, Michael P. Johnson, Sherri L. Andis, Darryle D. Schoepp   +8 more
openalex   +1 more source