Results 161 to 170 of about 79,817 (291)

N-Acetyl-Cysteine Causes Analgesia by Reinforcing the Endogenous Activation of Type-2 Metabotropic Glutamate Receptors [PDF]

, 2012
Matteo Bernabucci, Serena Notartomaso, Cristina Zappulla, Francesco Fazio, Milena Cannella, Marta Motolese, Giuseppe Battaglia, Valeria Bruno, Roberto Gradini, Ferdinando Nicoletti   +9 more
openalex   +1 more source

Agonist analysis of 2-(carboxy-cyclopropyl)glycines (CCGs) for cloned metabotropic glutamate receptor subtypes.

, 1993
Yasunori Hayashi, Yasuto Tanabe, Ichiro Aramori, Masayuki Masuyuki, Shigetada Nakanishi   +4 more
openalex   +1 more source

The Metabotropic Glutamate Receptor Subtype 5 Antagonist Fenobam Is Analgesic and Has Improved in Vivo Selectivity Compared with the Prototypical Antagonist 2-Methyl-6-(phenylethynyl)-pyridine [PDF]

, 2009
Michael C. Montana, Laura F. Cavallone, Kristi K. Stubbert, Andrei D. Stefanescu, Evan D. Kharasch, Robert W. Gereau   +5 more
openalex   +1 more source

Synthesis and Evaluation in Monkey of [¹⁸F]4-Fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4-yl)thiazol-2-yl)benzamide ([¹⁸F]FIMX): A Promising Radioligand for PET Imaging of Brain Metabotropic Glutamate Receptor 1 (mGluR1)

, 2013
Rong Xu, Paolo Zanotti‐Fregonara, Sami S. Zoghbi, Robert L. Gladding, Alicia E. Woock, Robert B. Innis, Victor W. Pike   +6 more
openalex   +2 more sources

Chronic Clozapine Treatment Impairs Functional Activation of Metabotropic Glutamate Receptor 2 via an HDAC2-depedent Mechanism

, 2018
Travis Cuddy
openalex   +2 more sources

Structural determinants of allosteric antagonism at metabotropic glutamate receptor 2: mechanistic studies with new potent negative allosteric modulators

British Journal of Pharmacology, 2011
Linda Lundstrom, C. Bissantz, J. Beck, Joseph G. Wettstein, T. Woltering, J. Wichmann, Silvia Gatti   +6 more
semanticscholar   +1 more source

Synthesis of heterocyclic enol ethers and their use as group 2 metabotropic glutamate receptor antagonists

, 1999
Sabine Kolczewski, Geo Adam, Heinz Stadler, Vincent Mutel, Jürgen Wichmann, Thomas J. Woltering   +5 more
openalex   +1 more source

Design, Synthesis, and Characterization of Benzimidazole Derivatives as Positron Emission Tomography Imaging Ligands for Metabotropic Glutamate Receptor 2. [PDF]

J Med Chem, 2020
Yuan G, Qu X, Zheng B, Neelamegam R, Afshar S, Iyengar S, Pan C, Wang J, Kang HJ, Ondrechen MJ, Poutiainen P, El Fakhri G, Zhang Z, Brownell AL.   +13 more
europepmc   +1 more source

Role of P/Q-Ca2+ Channels in Metabotropic Glutamate Receptor 2/3-Dependent Presynaptic Long-Term Depression at Nucleus Accumbens Synapses

Journal of Neuroscience, 2002
David Robbe, G. Alonso, S. Chaumont, J. Bockaert, O. Manzoni   +4 more
semanticscholar   +1 more source

Covalent Allosteric Probe for the Metabotropic Glutamate Receptor 2

Covalent labeling of G protein-coupled receptors (GPCRs) by small molecules is a powerful approach to understand binding modes, mechanism of action, pharmacology, and even facilitate structure elucidation. We report the first covalent positive allosteric modulator (PAM) for a class C GPCR, the mGlu receptor.
Doornbos, Maarten L. J., Wang, Xuesong, Vermond, Sophie C., Peeters, Luc, Pérez-Benito, Laura||, Trabanco, Andrés A., Lavreysen, Hilde, Cid, José María, Heitman, Laura H., Tresadern, Gary||, IJzerman, Adriaan P.   +10 more
openaire   +1 more source