Results 161 to 170 of about 55,195 (280)

Synthesis and preliminary studies of ¹¹C-labeled tetrahydro-1,7-naphthyridine-2-carboxamides for PET imaging of metabotropic glutamate receptor 2. [PDF]

Theranostics, 2020
Zhang X, Zhang Y, Chen Z, Shao T, Van R, Kumata K, Deng X, Fu H, Yamasaki T, Rong J, Hu K, Hatori A, Xie L, Yu Q, Ye W, Xu H, Sheffler DJ, Cosford NDP, Shao Y, Tang P, Wang L, Zhang MR, Liang SH.   +22 more
europepmc   +1 more source

Sevoflurane Inhibits Layer 5 Pyramidal Neurons via Kv1.2‐Dependent Modulation of Subthreshold Currents

Journal of Neurochemistry, Volume 170, Issue 1, January 2026.
General anesthetics suppress cortical activity, but their cellular mechanisms remain unclear. We investigated how the volatile anesthetic sevoflurane affects layer 5 pyramidal neurons in the auditory cortex. Using patch‐clamp recordings and computational modeling, we found that low‐dose sevoflurane reduces neuronal firing through Kv1.2 channel ...
Aelton S. Araujo, Gabriel M. de Queiroz, Sérgio Ruschi B. Silva, Werner Treptow, Katarina E. Leao   +4 more
wiley   +1 more source

Phosphorylation-independent Regulation of Metabotropic Glutamate Receptor 5 Desensitization and Internalization by G Protein-coupled Receptor Kinase 2 in Neurons [PDF]

, 2009
Fabíola M. Ribeiro, Lucimar T. Ferreira, Maryse Paquet, Tamara Cregan, Qingming Ding, Robert Gros, Stephen S. G. Ferguson   +6 more
openalex   +1 more source

The P2X7 Receptor and Its Relation to Neglected Tropical Diseases: Focusing on Chagas Disease

Journal of Tropical Medicine, Volume 2026, Issue 1, 2026.
Chagas disease, caused by Trypanosoma cruzi, is a neglected tropical disease (NTD) that can lead to severe cardiac complications, including chronic Chagas cardiomyopathy. While NTDs are caused by a variety of pathogens—such as protozoa, bacteria, viruses, and helminths, Chagas disease remains underexplored, particularly regarding host immune responses.
Caroline de Souza Ferreira Pereira, Robson Xavier Faria, Wei Wang   +2 more
wiley   +1 more source

Endocannabinoid signaling modulates neurons of the pedunculopontine nucleus (PPN) via astrocytes. [PDF]

, 2014
The pedunculopontine nucleus (PPN) is known as the cholinergic part of the reticular activating system (RAS) and it plays an important role in transitions of slow-wave sleep to REM sleep and wakefulness.
Antal, Miklós, Bíró, Tamás, Hegyi, Zoltán, Kovács, Adrienn, Kőszeghy, Áron, Pál, Balázs Zoltán, Szücs, Péter, Vincze, János   +7 more
core  

5-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-2,3′-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity

, 2004
Jeffrey Roppe, Bowei Wang, Dehua Huang, Lida Tehrani, Theodore M. Kamenecka, Edwin J. Schweiger, Jeffery J. Anderson, Jesse Brodkin, Xiaohui Jiang, Merryl Cramer, Janice Chung, Grace Reyes-Manalo, Benito Muñoz, Nicholas D. P. Cosford   +13 more
openalex   +1 more source

3-[Substituted]-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitriles: Identification of highly potent and selective metabotropic glutamate subtype 5 receptor antagonists

, 2005
Lida Tehrani, Nicholas D. Smith, Dehua Huang, Steve F. Poon, Jeffrey Roppe, T. Jon Seiders, Deborah F. Chapman, Janice Chung, Merryl Cramer, Nicholas D. P. Cosford   +9 more
openalex   +1 more source

Metabotropic glutamate receptor subtype 2 (mGluR2; GRM2) [PDF]

Science-Business eXchange, 2013
openaire   +1 more source

Finely Tuned Gamma Oscillations in the Globus Pallidus Internus in Parkinson's Disease

Movement Disorders Clinical Practice, Volume 13, Issue 1, Page 294-296, January 2026.
Hikaru Kamo, Mallory L.S. Eisel, Jackson N. Cagle, Kara A. Johnson, Joshua Wong, Coralie de Hemptinne   +5 more
wiley   +1 more source

Synthesis, molecular modeling and preliminary biological evaluation of 1-amino-3-phosphono-3-cyclopentene-1-carboxylic acid and 1-amino-3-phosphono-2-cyclopentene-1-carboxylic acid, two novel agonists of metabotropic glutamate receptors of group III

, 2000
Laura Amori, Gabriele Costantino, Maura Marinozzi, Roberto Pellicciari, F. Gasparini, Peter J. Flor, Rainer Kühn, Ivo Vranesic   +7 more
openalex   +1 more source