Results 171 to 180 of about 55,195 (280)

N-Acetyl-Cysteine Causes Analgesia by Reinforcing the Endogenous Activation of Type-2 Metabotropic Glutamate Receptors [PDF]

, 2012
Matteo Bernabucci, Serena Notartomaso, Cristina Zappulla, Francesco Fazio, Milena Cannella, Marta Motolese, Giuseppe Battaglia, Valeria Bruno, Roberto Gradini, Ferdinando Nicoletti   +9 more
openalex   +1 more source

Discovery of 1-Butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1 H )-pyridone (JNJ-40411813): A Novel Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor

, 2014
José M. Cid, Gary Tresadern, Guillaume Duvey, Robert Lütjens, Terry Finn, Jean‐Philippe Rocher, Sonia Poli, Juan A. Vega, Ana Isabel de Lucas, Encarnación Matesanz, María Lourdes Linares, José Ignacio Andrés, Jesús Alcázar, José Manuel Alonso Segura, Gregor J. Macdonald, Daniel Oehlrich, Hilde Lavreysen, A. Ahnaou, Wilhelmus Drinkenburg, Claire Mackie, Stefan Pype, David J. Gallacher, Andrés A. Trabanco   +22 more
openalex   +1 more source

Regulation of spontaneous Ca²⁺ spikes by metabotropic glutamate receptors in primary cultures of rat cortical neurons [PDF]

, 2010
Kazumi Koga, Yuki Iwahori, Satoshi Ozaki, Hisashi Ohta   +3 more
openalex   +1 more source

Development of Novel, CNS Penetrant Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1 (mGlu₁), Based on an N-(3-Chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran-2-carboxamide Scaffold, That Potentiate Wild Type and Mutant mGlu₁ Receptors Found in Schizophrenics

, 2015
Pedro M. García-Barrantes, Hyekyung P. Cho, Colleen M. Niswender, Frank W. Byers, Charles W. Locuson, Anna L. Blobaum, Zixiu Xiang, Jerri M. Rook, P. Jeffrey Conn, Craig W. Lindsley   +9 more
openalex   +1 more source

Design and Synthesis of Systemically Active Metabotropic Glutamate Subtype-2 and -3 (mGlu_2/3) Receptor Positive Allosteric Modulators (PAMs): Pharmacological Characterization and Assessment in a Rat Model of Cocaine Dependence [PDF]

, 2014
Raveendra-Panickar Dhanya, Douglas J. Sheffler, Russell Dahl, Melinda Davis, Pooi San Lee, Li Yang, Hilary Highfield Nickols, Hyekyung P. Cho, Layton H. Smith, Manoranjan S. D’Souza, P. Jeffrey Conn, Andre Der‐Avakian, Athina Markou, Nicholas D. P. Cosford   +13 more
openalex   +1 more source

Design, Synthesis, and Characterization of Benzimidazole Derivatives as Positron Emission Tomography Imaging Ligands for Metabotropic Glutamate Receptor 2. [PDF]

J Med Chem, 2020
Yuan G, Qu X, Zheng B, Neelamegam R, Afshar S, Iyengar S, Pan C, Wang J, Kang HJ, Ondrechen MJ, Poutiainen P, El Fakhri G, Zhang Z, Brownell AL.   +13 more
europepmc   +1 more source

Synthesis and Evaluation in Monkey of [¹⁸F]4-Fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4-yl)thiazol-2-yl)benzamide ([¹⁸F]FIMX): A Promising Radioligand for PET Imaging of Brain Metabotropic Glutamate Receptor 1 (mGluR1)

, 2013
Rong Xu, Paolo Zanotti‐Fregonara, Sami S. Zoghbi, Robert L. Gladding, Alicia E. Woock, Robert B. Innis, Victor W. Pike   +6 more
openalex   +2 more sources

Development of Potent and Selective Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 2 for the Potential Treatment of Alzheimer’s Disease [PDF]

, 2023
Jeremy S. Coleman, Rory A. Capstick, Upendra Rathnayake, Lauren C. Parr, Sichen Chang, Analisa D. Thompson, Aidong Qi, Colleen M. Niswender, Olivier Boutaud, Hyekyung Plumley, Carrie K. Jones, Darren W. Engers, Craig W. Lindsley   +12 more
openalex   +1 more source

Neurotransmitter signaling in white matter [PDF]

, 2014
Butt, Arthur M., Fern, Robert F., Matute, Carlos   +2 more
core   +1 more source

Covalent Allosteric Probe for the Metabotropic Glutamate Receptor 2: Design, Synthesis, and Pharmacological Characterization. [PDF]

J Med Chem, 2019
Doornbos MLJ, Wang X, Vermond SC, Peeters L, Pérez-Benito L, Trabanco AA, Lavreysen H, Cid JM, Heitman LH, Tresadern G, IJzerman AP.   +10 more
europepmc   +1 more source