Results 171 to 180 of about 593,014 (300)

Could MDMA Promote Stemness Characteristics in Mouse Embryonic Stem Cells via mGlu5 Metabotropic Glutamate Receptors? [PDF]

Cell Journal, 2012
Objective: Ecstasy, or 3, 4 (±) methylenedioxymethamphetamine (MDMA), is a potent neurotoxic drug. One of the mechanisms for its toxicity is the secondary release of glutamate.
Rokhsareh Meamar, Fereshte Karamali, Seyed Ali Mousavi, Hossein Baharvand, Mohammad Hossein Nasr-Esfahani   +4 more
doaj  

Experience-dependent plasticity without long-term depression by type 2 metabotropic glutamate receptors in developing visual cortex [PDF]

, 2002
John J. Renger, Kenichi N. Hartman, Yoshiko Tsuchimoto, Mineto Yokoi, Shigetada Nakanishi, Takao K. Hensch   +5 more
openalex   +1 more source

Accuracy of direct gradient sensing by cell-surface receptors [PDF]

arXiv, 2009
Chemotactic cells of eukaryotic organisms are able to accurately sense shallow chemical concentration gradients using cell-surface receptors. This sensing ability is remarkable as cells must be able to spatially resolve small fractional differences in the numbers of particles randomly arriving at cell-surface receptors by diffusion.
arxiv  

Chronic cocaine enhances release of neuroprotective amino acid taurine: a microdialysis study [PDF]

, 2008
Cocaine inhibits high-affinity neurotransmitter uptake at the presynaptic nerve terminals to increase synaptic levels of dopamine, norepinephrine and serotonin^1^. This increase of synaptic dopamine may cause neurotoxicity^2,3^.
Eitan Freedman, Elena Yablonski-Alter, Eleonora Gashi, Mervan Agovic, Shailesh Banerjee, Theodore Lidsky   +5 more
core   +1 more source

Downstream Signaling of Muscarinic M4 Receptors Is Regulated by Receptor Density and Cellular Environment

Pharmacology Research &Perspectives, Volume 13, Issue 3, June 2025.
ABSTRACT Multiple muscarinic M4 receptor modulators are currently advancing in clinical development for the treatment of positive symptoms in schizophrenia, including agonists and positive allosteric modulators. Considering the importance of comprehending M4 receptor pharmacology for these therapeutic applications, this study investigates M4 receptor ...
Madeleine Merz, Charlotte Playle, Monika Palchaudhuri, Oliver Hucke, Ulrike Gross, Daniel Ursu   +5 more
wiley   +1 more source

Metabotropic Glutamate Receptor 5 Upregulation in A-Fibers after Spinal Nerve Injury: 2-Methyl-6-(Phenylethynyl)-Pyridine (MPEP) Reverses the Induced Thermal Hyperalgesia [PDF]

, 2002
Lindsey Hudson, Stuart Bevan, Kara McNair, Clive Gentry, Alyson Fox, Rainer Kühn, Janet Winter   +6 more
openalex   +1 more source

Synthesis and Characterization of 5-(2-Fluoro-4-[¹¹C]methoxyphenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide as a PET Imaging Ligand for Metabotropic Glutamate Receptor 2. [PDF]

J Med Chem, 2022
Yuan G, Dhaynaut M, Lan Y, Guehl NJ, Huynh D, Iyengar SM, Afshar S, Jain MK, Pickett JE, Kang HJ, Wang H, Moon SH, Ondrechen MJ, Wang C, Shoup TM, El Fakhri G, Normandin MD, Brownell AL.   +17 more
europepmc   +1 more source

Decoding the Taste of Peptides: Structure, Interactions With Taste Receptors, Bioactivities, and Applications

Sustainable Food Proteins, Volume 3, Issue 2, June 2025.
This comprehensive review highlights the role of taste‐active peptides (TAPs) in modulating food taste and promoting health. It explores the taste profile, structure, sources, interactions with taste receptors, bioactivity, and potential applications of TAPs within the food and nutraceutical industries.
Nesma Elhadad, Jianping Wu
wiley   +1 more source

A proteomic study to unveil lead toxicity-induced memory impairments invoked by synaptic dysregulation

Toxicology Reports, 2022
Lead (Pb2+), a ubiquitously present heavy metal toxin, has various detrimental effects on memory and cognition. However, the molecular processes affected by Pb2+ causing structural and functional anomalies are still unclear.
Nivedha Mohanraj, Neha S. Joshi, Roshni Poulose, Rahul R. Patil, Rashmi Santhoshkumar, Anubhav Kumar, Girish P. Waghmare, Amit Kumar Saha, Syeda Zehra Haider, Yogananda S. Markandeya, Gourav Dey, Laxmi T. Rao, Periyasamy Govindaraj, Bhupesh Mehta   +13 more
doaj  

Two Intracellular Pathways Mediate Metabotropic Glutamate Receptor-Induced Ca²⁺Mobilization in Dopamine Neurons [PDF]

, 2003
Hitoshi Morikawa, Kamran Khodakhah, John T. Williams   +2 more
openalex   +1 more source