Results 181 to 190 of about 52,074 (275)

Probing the lipid environment of the G-protein coupled receptor Metabotropic glutamate receptor 2

, 2019
The Metabotropic glutamate receptor 2 (mGluR2) belongs to the family of G-protein coupled receptors, a specific class of transmembrane proteins involved in cellular signaling. The functionality of such transmembrane proteins has been identified to largely depend on their microenvironment, namely the lipid bilayer surrounding them.
openaire   +2 more sources

Impact of metabotropic glutamate 2/3 receptor stimulation on activated dopamine release and locomotion

, 2010
Alan L. Pehrson, Bita Moghaddam
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Epigenetic Alterations in Prenatal Stress Mice as an Endophenotype Model for Schizophrenia: Role of Metabotropic Glutamate 2/3 Receptors [PDF]

, 2018
Francesco Matrisciano, Erbo Dong, Ferdinando Nicoletti, Alessandro Guidotti   +3 more
openalex   +1 more source

An allosteric modulator of metabotropic glutamate receptors (mGluR₂), (+)‐TFMPIP, inhibits restraint stress‐induced phasic glutamate release in rat prefrontal cortex

, 2012
Erin R. Hascup, Kevin N. Hascup, François Pomerleau, Peter Huettl, Éva Hajós‐Korcsok, Ján Kehr, Greg A. Gerhardt   +6 more
openalex   +1 more source

Metabotropic Glutamate Receptor 2 Expression Is Chronically Elevated in Male Rats With Post-Traumatic Stress Disorder Related Behavioral Traits Following Repetitive Low-Level Blast Exposure. [PDF]

J Neurotrauma
De Gasperi R, Gama Sosa MA, Perez Garcia G, Perez GM, Pryor D, Morrison CL, Lind R, Abutarboush R, Kawoos U, Statz JK, Patterson J, Hof PR, Zhu CW, Ahlers ST, Cook DG, Elder GA.   +15 more
europepmc   +1 more source

Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ-46281222. [PDF]

Br J Pharmacol, 2016
Doornbos ML, Pérez-Benito L, Tresadern G, Mulder-Krieger T, Biesmans I, Trabanco AA, Cid JM, Lavreysen H, IJzerman AP, Heitman LH.   +9 more
europepmc   +1 more source

Faculty Opinions recommendation of N-Acetyl-cysteine causes analgesia by reinforcing the endogenous activation of type-2 metabotropic glutamate receptors.

, 2013
Andrea Truini
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Ionic Lock: Functional Role in Activation of Metabotropic Glutamate Receptor 2 [PDF]

Biophysical Journal, 2017
Javier González-Maeso, Diomedes E. Logothetis, Amr Ellaithy, Takeharu Kawano, Yu Xu   +4 more
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Metabotropic Glutamate Receptor 2 Positive Allosteric Modulators: Closing the Gate on Drug Abuse? [PDF]

Biol Psychiatry, 2015
Johnson KA, Lovinger DM.
europepmc   +1 more source

Discovery of N-(5-Fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (VU0424238): A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Selected for Clinical Evaluation

, 2017
Andrew S. Felts, Alice L. Rodriguez, Anna L. Blobaum, Ryan D. Morrison, Brittney S. Bates, Analisa Thompson Gray, Jerri M. Rook, Mohammed Noor Tantawy, Frank W. Byers, Sichen Chang, Daryl F. Venable, Vincent B. Luscombe, Gilles Tamagnan, Colleen M. Niswender, J. Scott Daniels, Carrie K. Jones, P. Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte   +18 more
openalex   +1 more source