Results 11 to 20 of about 589,501 (292)

Molecular determinants of positive allosteric modulation of the human metabotropic glutamate receptor 2 [PDF]

British Journal of Pharmacology, 2015
Background and PurposeThe activation of the metabotropic glutamate receptor 2 (mGlu2) reduces glutamatergic transmission in brain regions where excess excitatory signalling is implicated in disorders such as anxiety and schizophrenia. Positive allosteric modulators (PAMs) can provide a fine‐tuned potentiation of these receptors' function and are being ...
A. Farinha, H. Lavreysen, L. Peeters, B. Russo, S. Masure, A. Trabanco, J. Cid, G. Tresadern   +7 more
semanticscholar   +3 more sources

Regulated Release of BDNF by Cortical Oligodendrocytes is Mediated Through Metabotropic Glutamate Receptors and the PLC Pathway [PDF]

ASN Neuro, 2009
A number of studies suggest that OLGs (oligodendrocytes), the myelinating cells of the central nervous system, are also a source of trophic molecules, such as neurotrophins that may influence survival of proximate neurons.
Issa P Bagayogo, Cheryl F Dreyfus
doaj   +4 more sources

Behavioral and Functional Evidence of Metabotropic Glutamate Receptor 2/3 and Metabotropic Glutamate Receptor 5 Dysregulation in Cocaine-Escalated Rats: Factor in the Transition to Dependence [PDF]

Biological Psychiatry, 2010
Rats with extended daily cocaine access show escalating cocaine self-administration and behavioral signs of dependence. Regulation of glutamatergic transmission by metabotropic glutamate receptors has emerged as a mechanism in the addictive actions of drugs of abuse.
Y. Hao, R. Martin‐Fardon, F. Weiss
semanticscholar   +4 more sources

The Selective Metabotropic Glutamate 2/3 Receptor Agonist MGS0028 Reverses Isolation Rearing–Induced Abnormal Behaviors in Mice

Journal of Pharmacological Sciences, 2012
Isolation-induced abnormal behaviors are useful animal models for assessing potential anti-psychotic drugs. This study examined the effect of MGS0028, a selective metabotropic glutamate 2/3 receptor agonist, on abnormal behaviors such as hyperactivity ...
Yukio Ago, Ryota Araki, Koji Yano, Toshiyuki Kawasaki, Shigeyuki Chaki, Atsuro Nakazato, Hirotaka Onoe, Hitoshi Hashimoto, Akemichi Baba, Kazuhiro Takuma, Toshio Matsuda   +10 more
doaj   +3 more sources

Metabotropic glutamate 2/3 receptors and epigenetic modifications in psychotic disorders: a review [PDF]

Current Neuropharmacology, 2016
Schizophrenia and Bipolar Disorder are chronic psychiatric disorders, both considered as "major psychosis"; they are thought to share some pathogenetic factors involving a dysfunctional gene x environment interaction.
Grayson, Danis R, Guidotti, Alessandro, MATRISCIANO, FRANCESCO, NICOLETTI, Ferdinando, PANACCIONE, ISABELLA   +4 more
core   +7 more sources

Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine‐induced down‐regulation of β‐adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands

Journal of Neurochemistry, 2005
AbstractAntidepressant drugs have a clinical latency that correlates with the development of neuroadaptive changes, including down‐regulation of β‐adrenergic receptors in different brain regions. The identification of drugs that shorten this latency will have a great impact on the treatment of major depressive disorders.
Francesco Matrisciano, Sergio Scaccianoce, Paolo Bianco, Isabella Panaccione, Anna M. Canudas, Giuseppe Battaglia, Barbara Riozzi, Richard Teke Ngomba, Gemma Molinaro, Roberto Tatarelli, Daniela Melchiorri, Ferdinando Nicoletti   +11 more
openalex   +5 more sources

Metabotropic glutamate receptor 2 inhibits thalamically-driven glutamate and dopamine release in the dorsal striatum

Neuropharmacology, 2017
The striatum plays critical roles in action control and cognition, and activity of striatal neurons is driven by glutamatergic input. Inhibition of glutamatergic inputs to projection neurons and interneurons of the striatum by presynaptic G protein-coupled receptors (GPCRs) stands to modulate striatal output and striatum-dependent behaviors.
Kari A. Johnson, Y. Mateo, D. Lovinger
semanticscholar   +4 more sources

SARS-CoV-2 uses metabotropic glutamate receptor subtype 2 as an internalization factor to infect cells

Cell Discovery, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses angiotensin-converting enzyme 2 (ACE2) as a binding receptor to enter cells via clathrin-mediated endocytosis (CME).
Jinliang Wang, Guan Yang, Xinxin Wang, Zhiyuan Wen, Lei Shuai, Jie Luo, Chong Wang, Ziruo Sun, Renqiang Liu, Jinying Ge, Xijun He, Ronghong Hua, Xijun Wang, Xiao Yang, Weiye Chen, Gongxun Zhong, Zhigao Bu   +16 more
doaj   +2 more sources

Psychedelic Targeting of Metabotropic Glutamate Receptor 2 and Its Implications for the Treatment of Alcoholism

Cells, 2023
Alcohol abuse is a leading risk factor for the public health burden worldwide. Approved pharmacotherapies have demonstrated limited effectiveness over the last few decades in treating alcohol use disorders (AUD).
Kevin Domanegg, Wolfgang H. Sommer, Marcus W. Meinhardt   +2 more
doaj   +3 more sources

Covalent Allosteric Probe for the Metabotropic Glutamate Receptor 2: Design, Synthesis, and Pharmacological Characterization [PDF]

Journal of Medicinal Chemistry, 2018
Covalent labeling of G protein-coupled receptors (GPCRs) by small molecules is a powerful approach to understand binding modes, mechanism of action, pharmacology, and even facilitate structure elucidation. We report the first covalent positive allosteric modulator (PAM) for a class C GPCR, the mGlu2 receptor.
Maarten L. J. Doornbos, Xuesong Wang, Sophie C. Vermond, Luc Peeters, Laura Pérez‐Benito, Andrés A. Trabanco, Hilde Lavreysen, José M. Cid, Laura H. Heitman, Gary Tresadern, Adriaan P. IJzerman   +10 more
openalex   +6 more sources