Results 11 to 20 of about 52,982 (243)

Metabotropic glutamate receptor 2 inhibits thalamically-driven glutamate and dopamine release in the dorsal striatum. [PDF]

Neuropharmacology, 2017
The striatum plays critical roles in action control and cognition, and activity of striatal neurons is driven by glutamatergic input. Inhibition of glutamatergic inputs to projection neurons and interneurons of the striatum by presynaptic G protein-coupled receptors (GPCRs) stands to modulate striatal output and striatum-dependent behaviors.
Johnson KA, Mateo Y, Lovinger DM.
europepmc   +5 more sources

Loss of metabotropic glutamate receptor 2 escalates alcohol consumption. [PDF]

Proc Natl Acad Sci U S A, 2013
Significance Gene identification for complex behavioral traits, alcoholism in particular, has been largely unsuccessful, in part because of the rarity of many causative variants and the heterogeneity and small effect size of the causal loci. Artificially selected animals may be valuable in gene identification.
Zhou Z, Karlsson C, Liang T, Xiong W, Kimura M, Tapocik JD, Yuan Q, Barbier E, Feng A, Flanigan M, Augier E, Enoch MA, Hodgkinson CA, Shen PH, Lovinger DM, Edenberg HJ, Heilig M, Goldman D.   +17 more
europepmc   +6 more sources

Molecular determinants of positive allosteric modulation of the human metabotropic glutamate receptor 2. [PDF]

Br J Pharmacol, 2015
Background and PurposeThe activation of the metabotropic glutamate receptor 2 (mGlu2) reduces glutamatergic transmission in brain regions where excess excitatory signalling is implicated in disorders such as anxiety and schizophrenia. Positive allosteric modulators (PAMs) can provide a fine‐tuned potentiation of these receptors' function and are being ...
Farinha A, Lavreysen H, Peeters L, Russo B, Masure S, Trabanco AA, Cid J, Tresadern G.   +7 more
europepmc   +5 more sources

Elevated level of metabotropic glutamate receptor 2/3 in the prefrontal cortex in major depression [PDF]

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2010
Clinical, postmortem and preclinical research strongly implicates dysregulation of glutamatergic neurotransmission in major depressive disorder (MDD). Recently, metabotropic glutamate receptors (mGluRs) have been proposed as attractive targets for the discovery of novel therapeutic approaches against depression.
A. Feyissa, W. Woolverton, J. Miguel-Hidalgo, Zhixia Wang, P. Kyle, G. Hasler, C. Stockmeier, A. Iyo, B. Karolewicz   +8 more
semanticscholar   +4 more sources

Covalent Allosteric Probe for the Metabotropic Glutamate Receptor 2: Design, Synthesis, and Pharmacological Characterization. [PDF]

J Med Chem, 2019
Covalent labeling of G protein-coupled receptors (GPCRs) by small molecules is a powerful approach to understand binding modes, mechanism of action, pharmacology, and even facilitate structure elucidation. We report the first covalent positive allosteric modulator (PAM) for a class C GPCR, the mGlu2 receptor.
Doornbos MLJ, Wang X, Vermond SC, Peeters L, Pérez-Benito L, Trabanco AA, Lavreysen H, Cid JM, Heitman LH, Tresadern G, IJzerman AP.   +10 more
europepmc   +8 more sources

Pharmacology of Metabotropic Glutamate Receptor 2 Homo‐ and Heterodimers

The FASEB Journal, 2020
Metabotropic Glutamate Receptors (mGluRs) are a family of class C g‐protein coupled receptors (GPCRs) that respond to glutamate as their native agonist.
Tyler W. McCullock, P. Kammermeier
semanticscholar   +2 more sources

Role of P/Q-Ca2+ Channels in Metabotropic Glutamate Receptor 2/3-Dependent Presynaptic Long-Term Depression at Nucleus Accumbens Synapses [PDF]

Journal of Neuroscience, 2002
David Robbe, G. Alonso, S. Chaumont, J. Bockaert, O. Manzoni   +4 more
semanticscholar   +2 more sources

Synthesis and preliminary studies of ¹¹C-labeled tetrahydro-1,7-naphthyridine-2-carboxamides for PET imaging of metabotropic glutamate receptor 2. [PDF]

Theranostics, 2020
Zhang X, Zhang Y, Chen Z, Shao T, Van R, Kumata K, Deng X, Fu H, Yamasaki T, Rong J, Hu K, Hatori A, Xie L, Yu Q, Ye W, Xu H, Sheffler DJ, Cosford NDP, Shao Y, Tang P, Wang L, Zhang MR, Liang SH.   +22 more
europepmc   +2 more sources

Metabotropic Glutamate Receptor 2 and 3 Gene Expression in The Human Prefrontal Cortex and Mesencephalon in Schizophrenia [PDF]

International Journal of Neuroscience, 2008
S. Ghose, J. Crook, Cynthia L. Bartus, T. Sherman, M. Herman, T. Hyde, J. Kleinman, M. Akil   +7 more
semanticscholar   +2 more sources

Design, Synthesis, and Characterization of Benzimidazole Derivatives as Positron Emission Tomography Imaging Ligands for Metabotropic Glutamate Receptor 2. [PDF]

J Med Chem, 2020
Yuan G, Qu X, Zheng B, Neelamegam R, Afshar S, Iyengar S, Pan C, Wang J, Kang HJ, Ondrechen MJ, Poutiainen P, El Fakhri G, Zhang Z, Brownell AL.   +13 more
europepmc   +3 more sources