Loss of metabotropic glutamate receptor 2 escalates alcohol consumption. [PDF]
Proc Natl Acad Sci U S A, 2013 Significance Gene identification for complex behavioral traits, alcoholism in particular, has been largely unsuccessful, in part because of the rarity of many causative variants and the heterogeneity and small effect size of the causal loci. Artificially selected animals may be valuable in gene identification.
Zhou Z +17 more
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Metabotropic glutamate receptor 2 inhibits thalamically-driven glutamate and dopamine release in the dorsal striatum. [PDF]
Neuropharmacology, 2017 The striatum plays critical roles in action control and cognition, and activity of striatal neurons is driven by glutamatergic input. Inhibition of glutamatergic inputs to projection neurons and interneurons of the striatum by presynaptic G protein-coupled receptors (GPCRs) stands to modulate striatal output and striatum-dependent behaviors.
Johnson KA, Mateo Y, Lovinger DM.
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Molecular determinants of positive allosteric modulation of the human metabotropic glutamate receptor 2. [PDF]
Br J Pharmacol, 2015 Background and PurposeThe activation of the metabotropic glutamate receptor 2 (mGlu2) reduces glutamatergic transmission in brain regions where excess excitatory signalling is implicated in disorders such as anxiety and schizophrenia. Positive allosteric modulators (PAMs) can provide a fine‐tuned potentiation of these receptors' function and are being ...
Farinha A +7 more
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Pharmacology of Metabotropic Glutamate Receptor 2 Homo‐ and Heterodimers
The FASEB Journal, 2020 Metabotropic Glutamate Receptors (mGluRs) are a family of class C g‐protein coupled receptors (GPCRs) that respond to glutamate as their native agonist.
Tyler W. McCullock, P. Kammermeier
semanticscholar +2 more sources
Metabotropic glutamate 2/3 receptors and epigenetic modifications in psychotic disorders: a review [PDF]
Current Neuropharmacology, 2016 Schizophrenia and Bipolar Disorder are chronic psychiatric disorders, both considered as "major psychosis"; they are thought to share some pathogenetic factors involving a dysfunctional gene x environment interaction.
Grayson, Danis R +4 more
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A Case Series of Anti-Metabotropic Glutamate Receptor 2 Antibody-Related Diseases with Distinct Neurological Involvement [PDF]
ImmunoTargets and TherapyZhanwei Zhang,1 Xiaolu Deng,1 Dandan Guo,1 Jie Zhao,2 Jian Li,2 Fang He,1,3 Lifen Yang,1,3 Jing Peng1,3 1Department of Pediatrics, Xiangya Hospital of Central South University, Changsha, Hunan Province, People’s Republic of China; 2Department of ...
Zhang Z +7 more
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Cell Discovery, 2021 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses angiotensin-converting enzyme 2 (ACE2) as a binding receptor to enter cells via clathrin-mediated endocytosis (CME).
Jinliang Wang +16 more
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Age-dependent impairment of metabotropic glutamate receptor 2-dependent long-term depression in the mouse striatum by chronic ethanol exposure. [PDF]
Alcohol, 2020 Johnson KA +3 more
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Metabotropic glutamate receptor subtype 2 is a receptor of SARS-CoV-2 [PDF]
, 2021 Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative pathogen of novel coronavirus disease 2019 (COVID-19)1. SARS-CoV-2 uses angiotensin converting enzyme 2 (ACE2) as a cellular receptor and enters cells via clathrin-mediated endocytosis (CME)2-4.
Zhigao Bu +16 more
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