Soluble Ectodomain of Neuroligin 1 Decreases Synaptic Activity by Activating Metabotropic Glutamate Receptor 2 [PDF]
Frontiers in Molecular Neuroscience, 2017 Synaptic cell adhesion molecules represent important targets for neuronal activity-dependent proteolysis. Postsynaptic neuroligins (NLs) form trans-synaptic complexes with presynaptic neurexins (NXs). Both NXs and NLs are cleaved from the cell surface by
Michelle D. Gjørlund +9 more
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Metabotropic Glutamate 2/3 Receptors and Epigenetic Modifications in Psychotic Disorders: A Review [PDF]
Current Neuropharmacology, 2016 Schizophrenia and Bipolar Disorder are chronic psychiatric disorders, both considered as "major psychosis"; they are thought to share some pathogenetic factors involving a dysfunctional gene x environment interaction. Alterations in the glutamatergic transmission have been suggested to be involved in the pathogenesis of psychosis.
MATRISCIANO, FRANCESCO +4 more
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A Case Series of Anti-Metabotropic Glutamate Receptor 2 Antibody-Related Diseases with Distinct Neurological Involvement [PDF]
ImmunoTargets and TherapyZhanwei Zhang,1 Xiaolu Deng,1 Dandan Guo,1 Jie Zhao,2 Jian Li,2 Fang He,1,3 Lifen Yang,1,3 Jing Peng1,3 1Department of Pediatrics, Xiangya Hospital of Central South University, Changsha, Hunan Province, People’s Republic of China; 2Department of ...
Zhang Z +7 more
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Metabotropic Glutamate Receptors 2 and 3 as Targets for Treating Nicotine Addiction. [PDF]
Biol Psychiatry, 2018 Tobacco smoking, driven by the addictive properties of nicotine, continues to be a worldwide health problem. Based on the well-established role of glutamatergic neurotransmission in drug addiction, novel medication development strategies seek to halt nicotine consumption and prevent relapse to tobacco smoking by modulating glutamate transmission.
Cross AJ, Anthenelli R, Li X.
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Age-dependent impairment of metabotropic glutamate receptor 2-dependent long-term depression in the mouse striatum by chronic ethanol exposure. [PDF]
Alcohol, 2020 Johnson KA +3 more
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Molecular determinants of positive allosteric modulation of the human metabotropic glutamate receptor 2. [PDF]
Br J Pharmacol, 2015 Background and PurposeThe activation of the metabotropic glutamate receptor 2 (mGlu2) reduces glutamatergic transmission in brain regions where excess excitatory signalling is implicated in disorders such as anxiety and schizophrenia. Positive allosteric modulators (PAMs) can provide a fine‐tuned potentiation of these receptors' function and are being ...
Farinha A +7 more
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Operant self-stimulation of thalamic terminals in the dorsomedial striatum is constrained by metabotropic glutamate receptor 2. [PDF]
Neuropsychopharmacology, 2020 Johnson KA +4 more
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Metabotropic Glutamate Receptor 2 Positive Allosteric Modulators: Closing the Gate on Drug Abuse? [PDF]
Biol Psychiatry, 2015 Johnson KA, Lovinger DM.
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Metabotropic Glutamate Receptor 2/3 (mGluR2/3) Activation Suppresses TRPV1 Sensitization in Mouse, But Not Human, Sensory Neurons. [PDF]
eNeuro, 2018 The use of human tissue to validate putative analgesic targets identified in rodents is a promising strategy for improving the historically poor translational record of preclinical pain research.
Sheahan TD +5 more
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Metabotropic glutamate receptor subtype 2 (GRM2; MGLUR2); GRM3 (MGLUR3) [PDF]
Science-Business eXchange, 2010 openalex +2 more sources