Results 191 to 200 of about 593,014 (300)

Dysregulation of Astrocytic ATP/Adenosine Release in the Hippocampus Cause Cognitive and Affective Disorders: Molecular Mechanisms, Diagnosis, and Therapy

MedComm, Volume 6, Issue 5, May 2025.
Reactive astrocytes release various molecules, which play a role in maintaining central nervous system (CNS) homeostasis. (1) Gliotransmitters, such as glutamate, γ‐aminobutyric acid (GABA), ATP, and D‐serine, are secreted by vesicular exocytosis. In addition, astrocytes can also release ATP and glutamate through (2) P2X7Rs, (3) connexin‐43 (Cx43 ...
Peter Illes, Patrizia Rubini, Henning Ulrich, Hai‐Yan Yin, Yong Tang   +4 more
wiley   +1 more source

Meclizine and metabotropic glutamate receptor agonists attenuate severe pain and primary sensory neuron Ca²⁺activity in chemotherapy-induced peripheral neuropathy [PDF]

, 2021
John Shannonhouse, Matteo Bernabucci, Ruben Gomez, Hyeonwi Son, Yan Zhang, Hirotake Ishida, Yu Shin Kim   +6 more
openalex   +1 more source

Mechanism and Prevention of Hyperbaric Oxygen Convulsions [PDF]

arXiv
Hyperbaric oxygen therapy (HBOT) proves vital in saving lives by elevating the partial pressure of oxygen (pO2). However, HBOT may also have toxic effects, including lung and retinal damage (peripheral HBOT toxicity), muscle spasms and violent myoclonic convulsions (CNS HBOT toxicity), which may even lead to death if left untreated.
arxiv  

Penta‐ALFA‐Tagged Substrates for Self‐Labelling Tags Allow Signal Enhancement in Microscopy

Journal of Peptide Science, Volume 31, Issue 5, May 2025.
A pentaALFA peptide may be reacted with a SNAP‐ or HaloTag and allows for signal enhancement using fluorescently labelled nanobodies. Tagged and peptide/nanobody treated cell surface receptors give generally higher signal intensity using fluorescence microscopy and are amenable for stimulated emission by depletion (STED) super‐resolution imaging ...
Souvik Ghosh, Ramona Birke, Ashwin Karthick Natarajan, Johannes Broichhagen   +3 more
wiley   +1 more source

The Metabotropic Glutamate 2/3 Receptor Agonist LY379268 Blocked Nicotine-Induced Increases in Nucleus Accumbens Shell Dopamine only in the Presence of a Nicotine-Associated Context in Rats [PDF]

, 2011
Manoranjan S. D’Souza, Matthias E. Liechti, Ana M. Ramirez-Niño, Ronald Kuczenski, Athina Markou   +4 more
openalex   +1 more source

Optogluram-2: a subtype-selective photoswitchable positive allosteric modulator for metabotropic glutamate receptor 4 [PDF]

, 2023
Silvia Panarello, Aleix González-Díez, Alice E. Berizzi, Fanny Malhaire, Roser Borràs‐Tudurí, Xavier Rovira, Laurent Prézeau, Jean‐Philippe Pin, Cyril Goudet, Amadeu Llebaria, Xavier Gómez‐Santacana   +10 more
openalex   +1 more source

A Molecular Communication Perspective of Alzheimer's Disease: Impact of Amyloid Beta Oligomers on Glutamate Diffusion in the Synaptic Cleft [PDF]

arXiv
Molecular communication (MC) within the synaptic cleft is vital for neurotransmitter diffusion, a process critical to cognitive functions. In Alzheimer's Disease (AD), beta-amyloid oligomers (A$\beta$os) disrupt this communication, leading to synaptic dysfunction.
arxiv  

Operant self-stimulation of thalamic terminals in the dorsomedial striatum is constrained by metabotropic glutamate receptor 2. [PDF]

Neuropsychopharmacology, 2020
Johnson KA, Voyvodic L, Loewinger GC, Mateo Y, Lovinger DM.   +4 more
europepmc   +1 more source

Development of a high‐throughput dual‐stream liquid chromatography–tandem mass spectrometry method to screen for inhibitors of glutamate carboxypeptidase II

Rapid Communications in Mass Spectrometry, Volume 39, Issue S1, May 2025.
Rationale Glutamate carboxypeptidase II (GCPII) catalyzes the hydrolysis of N‐acetylaspartylglutamate (NAAG) to yield glutamate (Glu) and N‐acetylaspartate (NAA). Inhibition of GCPII has been shown to remediate the neurotoxicity of excess Glu in a variety of cell and animal disease models.
Nate Hoxie, Yixuan Qiu, Stephen C. Kales, Rick Schneider, Xin Hu, Anu Dalal, Stephanie L. Ford‐Scheimer, Robyn Wiseman, Takashi Tsukamoto, Huijun Wei, Barbara S. Slusher, John S. Janiszewski, Matthew D. Hall   +12 more
wiley   +1 more source

(2S,1’R, 2'R, 3'R)-2-(2,3-Dicarboxycyclopropyl)-glycine (DCG-IV): A type-specific agonist for metabotropic glutamate receptor negatively coupled with adenylate cyclase in rat hippocampus.

, 1994
Mutsumi Maruyama, Mariko Nakazawa
openalex   +1 more source