Results 231 to 240 of about 52,074 (275)

Cholesterol Localization around the Metabotropic Glutamate Receptor 2

The Journal of Physical Chemistry B, 2020
The metabotropic glutamate receptor (mGluR) 2 plays a key role in the central nervous system. mGluR2 has been shown to be regulated by its surrounding lipid environment, especially by cholesterol, by an unknown mechanism. Here, using a combination of biochemical approaches, photo-cross-linking experiments, and molecular dynamics simulations we show the
Rainer D. Beck, Camilo Aponte-Santamaría, Camilo Aponte-Santamaría, Alexandra Teslenko, Britta Brügger, Angelica Sandoval-Perez, Irmgard Sinning, Fabio Lolicato, Helman Amaya-Espinosa, Markus Kurth   +9 more
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Pharmacology of Metabotropic Glutamate Receptor 2 Homo‐ and Heterodimers

The FASEB Journal, 2020
Metabotropic Glutamate Receptors (mGluRs) are a family of class C g‐protein coupled receptors (GPCRs) that respond to glutamate as their native agonist. The eight members of the mGluR family are widely expressed across the nervous and are primarily charged with shaping and fine‐tuning neuronal excitability and synaptic efficacy. Like most class C GPCRs,
Paul J. Kammermeier, Tyler William McCullock   +1 more
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Metabotropic Glutamate Receptor 2 Activators [PDF]

, 2014
Schizophrenia is a common and severe, often disabling psychiatric illness of unknown aetiology that affects approximately 24 million people worldwide. The illness is characterized by symptomatology comprising positive symptoms (hallucinations and delusional behaviours), negative symptoms (anhedonia, social withdrawal and apathy) and cognitive ...
José María Cid, Hilde Lavreysen, Andrés A. Trabanco   +2 more
openaire   +1 more source

LocaliZation of metabotropic glutamate receptor type 2 in the human brain

Neuroscience, 1999
Metabotropic glutamate receptors are a heterogeneous family of G-protein-coupled receptors that are linked to multiple second messenger systems to regulate neuronal excitability and synaptic transmission. To elucidate the physiological role of these receptors in human central nervous system function and dysfunction at the receptor protein level ...
Sarah J. Augood, Clive N. Svendsen, Henry J. Waldvogel, Piers C. Emson, Richard L.M. Faull, S. Rees, T. Phillips   +6 more
openaire   +3 more sources

Specificity of Metabotropic Glutamate Receptor 2 Coupling to G Proteins

Molecular Pharmacology, 2003
Metabotropic glutamate receptor 2 (mGluR2) is a class 3 G protein-coupled receptor and an important mediator of synaptic activity in the central nervous system. Previous work demonstrated that mGluR2 couples to pertussis toxin (PTX)-sensitive G proteins. However, the specificity of mGluR2 coupling to individual members of the G(i/o) family is not known.
Paul J. Kammermeier, Margaret I. Davis, Stephen R. Ikeda   +2 more
openaire   +3 more sources

Chemical Switch of a Metabotropic Glutamate Receptor 2 Silent Allosteric Modulator into Dual Metabotropic Glutamate Receptor 2/3 Negative/Positive Allosteric Modulators

Journal of Medicinal Chemistry, 2010
Using an mGluR2 FRET-based binding assay, binders of the transmembrane region devoid of functional activity were identified. It is reported that slight chemical modifications of these SAMs can dramatically change activity of the resulting analogues without altering their affinities.
Christel Franchet, Pascal Neuville, Mélanie Frauli, Stanislas Mayer, Edith Steinberg, Luc Baron, Stephan Schann, Mireille Thomas   +7 more
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Activation of the extracellular signal‐regulated kinase 2 by metabotropic glutamate receptors

European Journal of Neuroscience, 1999
AbstractActivation of metabotropic glutamate receptors (mGluRs) leads to modulation of a variety of second messenger pathways probably including the mitogen‐activated protein kinase (MAPK) extracellular signal‐regulated protein kinases (ERK). MAPK play a key role in the control of cellular responses to changes in the external environment by regulating ...
Ferraguti F., Baldani-Guerra B., Corsi M., Nakanishi S., Corti C.   +4 more
openaire   +3 more sources

Pyrimidine Methyl Anilines: Selective Potentiators for the Metabotropic Glutamate 2 Receptor

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Hu Essa H, Lida R. Tehrani, Jean-Michel Vernier, Peter C. Chua, Nicholas D. P. Cosford, Anthony B. Pinkerton, John H. Hutchinson, Blake A. Rowe, Johnny Y. Nagasawa   +8 more
openaire   +4 more sources

New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III

Journal of Medicinal Chemistry, 2016
The metabotropic glutamate (Glu) receptors (mGluRs) play key roles in modulating excitatory neurotransmission in the brain. In all, eight subtypes have been identified and divided into three groups, group I (mGlu1,5), group II (mGlu2,3), and group III (mGlu4,6-8).
Robb Brodbeck, Mette N. Erichsen, Amélie S. Tora, Amélie S. Tora, Thierry Gefflaut, Thierry Gefflaut, Emmanuelle Sagot, Emmanuelle Sagot, Cyril Goudet, Cyril Goudet, Christian Thomsen, Lennart Bunch, Birgitte Nielsen, Tri H. V. Huynh, Jean-Philippe Pin, Jean-Philippe Pin, Walden E. Bjørn-Yoshimoto, Zeinab Assaf, Zeinab Assaf, Tine B. Stensbøl   +19 more
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Lack of effect of LY314582 (a group 2 metabotropic glutamate receptor agonist) on phencyclidine-induced locomotor activity in metabotropic glutamate receptor 2 knockout mice

European Journal of Pharmacology, 2000
In metabotropic glutamate receptor 2 (mGlu(2)) knockout mice, the group 2 metabotropic glutamate receptor agonist LY314582 (20 mg/kg, i.p.), a racemate of LY354740, inhibits neither spontaneous nor phencyclidine (PCP)-induced (2.5 mg/kg, s.c.) locomotor activity.
Manuel Koller, Herman van der Putten, Shigetada Nakanishi, Will P.J.M Spooren, Rainer Kuhn, Fabrizio Gasparini   +5 more
openaire   +3 more sources