Results 231 to 240 of about 55,195 (280)

Glutamate Receptor Agonists as Triggers of Neurotoxicity: Decoding Pathways of Five Neurotoxins and Potential Therapeutic Targets. [PDF]

ACS Omega
Turcatel GA, Moura S.
europepmc   +1 more source

Glutamate-associated research in Parkinson's disease: a bibliometric analysis. [PDF]

Front Aging Neurosci
Chen YJ, Xie MR, Zhou SQ, Liu F.
europepmc   +1 more source

Candidate gene mutations of patients with astrocytoma who present with seizures: evidence from whole exome sequencing. [PDF]

Front Oncol
Phabphal K, Choochuen P, Kaewborisutsakul A, Tunthanathip T, Sangkhathat S.   +4 more
europepmc   +1 more source

ASTROGLIA: Molecular Mechanisms, Functional Roles, and Neurophysiological Implications in the Central Nervous System. [PDF]

Life (Basel)
Ortega A, Martínez-Nuncio LA, Taddei E, Castañeda E, Rubio C, Rubio-Osornio M.   +5 more
europepmc   +1 more source

Modulation of Metabotropic Glutamate Receptors as a Strategy to Improve the Efficacy and Safety of Ketamine as an Antidepressant. [PDF]

Cells
Pałucha-Poniewiera A.
europepmc   +1 more source

The Role of Ion Channels and Transporters in Human Health and Diseases. [PDF]

Biomedicines
Soda T.
europepmc   +1 more source

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Cholesterol Localization around the Metabotropic Glutamate Receptor 2

The Journal of Physical Chemistry B, 2020
The metabotropic glutamate receptor (mGluR) 2 plays a key role in the central nervous system. mGluR2 has been shown to be regulated by its surrounding lipid environment, especially by cholesterol, by an unknown mechanism. Here, using a combination of biochemical approaches, photo-cross-linking experiments, and molecular dynamics simulations we show the
Markus Kurth, Fabio Lolicato, Angelica Sandoval-Perez, Helman Amaya-Espinosa, Alexandra Teslenko, Irmgard Sinning, Rainer Beck, Britta Brügger, Camilo Aponte-Santamaría   +8 more
openaire   +2 more sources

Pharmacology of Metabotropic Glutamate Receptor 2 Homo‐ and Heterodimers

The FASEB Journal, 2020
Metabotropic Glutamate Receptors (mGluRs) are a family of class C g‐protein coupled receptors (GPCRs) that respond to glutamate as their native agonist. The eight members of the mGluR family are widely expressed across the nervous and are primarily charged with shaping and fine‐tuning neuronal excitability and ...
Tyler William McCullock, Paul Kammermeier   +1 more
openaire   +1 more source

Specificity of Metabotropic Glutamate Receptor 2 Coupling to G Proteins

Molecular Pharmacology, 2003
Metabotropic glutamate receptor 2 (mGluR2) is a class 3 G protein-coupled receptor and an important mediator of synaptic activity in the central nervous system. Previous work demonstrated that mGluR2 couples to pertussis toxin (PTX)-sensitive G proteins. However, the specificity of mGluR2 coupling to individual members of the G(i/o) family is not known.
Paul J, Kammermeier, Margaret I, Davis, Stephen R, Ikeda   +2 more
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Chemical Switch of a Metabotropic Glutamate Receptor 2 Silent Allosteric Modulator into Dual Metabotropic Glutamate Receptor 2/3 Negative/Positive Allosteric Modulators

Journal of Medicinal Chemistry, 2010
Using an mGluR2 FRET-based binding assay, binders of the transmembrane region devoid of functional activity were identified. It is reported that slight chemical modifications of these SAMs can dramatically change activity of the resulting analogues without altering their affinities.
Stephan, Schann, Stanislas, Mayer, Christel, Franchet, Mélanie, Frauli, Edith, Steinberg, Mireille, Thomas, Luc, Baron, Pascal, Neuville   +7 more
openaire   +2 more sources