Results 251 to 260 of about 55,195 (280)

Metabotropic glutamate receptor 2/3 immunoreactivity in the developing rat cerebellar cortex

The Journal of Comparative Neurology, 1999
In adult rat cerebellar cortex, the metabotropic glutamate receptors (mGluRs) 2 and 3 (mGluR2/3) are present in somata, dendrites, and terminals of Golgi cells as well as in presumed glial processes (Ohishi et al. [1994], Neuron 13:55-66). In the present study, spatiotemporal changes in immunostaining for mGluR2/3 were examined in postnatal rat ...
Meguro, R., Ohishi, H., Hoshino, K., Hicks, T., Norita, M.   +4 more
openaire   +3 more sources

Activation of the extracellular signal‐regulated kinase 2 by metabotropic glutamate receptors

European Journal of Neuroscience, 1999
AbstractActivation of metabotropic glutamate receptors (mGluRs) leads to modulation of a variety of second messenger pathways probably including the mitogen‐activated protein kinase (MAPK) extracellular signal‐regulated protein kinases (ERK). MAPK play a key role in the control of cellular responses to changes in the external environment by regulating ...
Ferraguti F., Baldani-Guerra B., Corsi M., Nakanishi S., Corti C.   +4 more
openaire   +2 more sources

Morphine withdrawal increases metabotropic glutamate 2/3 receptors expression in nucleus accumbens

NeuroReport, 2008
We examined the effects of chronic morphine treatment and withdrawal on the expression of metabotropic glutamate (mGlu)1, mGlu5, and mGlu2/3 receptors in the nucleus accumbens and caudate putamen. Rats received a 14-day morphine treatment (escalating doses from 10 to 140 mg/kg). Receptor density was evaluated after chronic treatment and after 1, 3, and
Antonella M. E. Modafferi, Marco Diana, NICOLETTI, Ferdinando, SCACCIANOCE, Sergio   +3 more
openaire   +4 more sources

Metabotropic Glutamate 2 (mGlu2) Receptors and Schizophrenia Treatment

2017
Although it is not without controversy, recent preclinical and clinical studies suggest that activation of metabotropic glutamate 2 (mGlu2) receptors by orthosteric mGlu2/3 receptor agonists or allosteric mGlu2 receptor agonists represents a potential new approach to treat schizophrenia and other psychotic disorders.
openaire   +1 more source

(+)-2-Methyl-4-carboxyphenylglycine (LY367385) selectively antagonises metabotropic glutamate mGluR1 receptors

Bioorganic & Medicinal Chemistry Letters, 1997
Abstract The synthesis of three novel 4-carboxyphenylglycine derivatives is described. 2-Methyl substituents increase the antagonist potency compared to (S)-4CPG at mGluR1 receptors. Resolution of compound 1 showed that the activity resided in the (+)-isomer LY367385.
Barry P. Clark, S.Richard Baker, John Goldsworthy, John R. Harris, Ann E. Kingston   +4 more
openaire   +1 more source

Metabotropic glutamate receptors 2 and 3 expressed by astrocytes in rat ventrobasal thalamus

Neuroscience Letters, 1999
It has been reported that pharmacologic activation of metabotropic receptors mGluR2/3 may produce inhibition of GABAergic transmission in rat ventrobasal thalamus. We use double immunolabeling to show that: (i) mGluR2/3 is expressed in glial processes surrounding GABAergic terminals, rather than in the terminals themselves, and (ii) mR2/3 positive ...
E, Mineff, J, Valtschanoff
openaire   +2 more sources

Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Laura A Huppert, Hope S Rugo
exaly  

Metabotropic Glutamate Receptor 2 Activation: Computational Predictions and Experimental Validation

2018
VCU Theses and ...
openaire   +1 more source

Chimeric antigen receptor T‐cell therapy in multiple myeloma: A comprehensive review of current data and implications for clinical practice

Ca-A Cancer Journal for Clinicians, 2023

exaly  

Critical care management of chimeric antigen receptor T‐cell therapy recipients

Ca-A Cancer Journal for Clinicians, 2022
Alexander Shimabukuro-Vornhagen, Boris Böll, Victoria Metaxa   +2 more
exaly