Results 261 to 270 of about 593,014 (300)

Gene mutations linked to drug-resistant epilepsy in astrocytoma. [PDF]

Front Neurol
Phabphal K, Kaewborisutsakul A, Leetanaporn K, Choochuen P, Tunthanathip T, Navakanitworakul R, Sangkhathat S.   +6 more
europepmc   +1 more source

Amelioration of Glutamate-induced Toxicity by a New Thyrotropin-releasing Hormone (TRH) Analogue PYR-l-(2,5-Dibromo)-His-l-ProNH₂. [PDF]

Ann Neurosci
Sunkara MR, Singh JN, Meena CL, Pant AB, Jain R, Sharma SS.   +5 more
europepmc   +1 more source

Structure-Activity Relationship of NMDA Receptor Ligands and Their Activities on the ERK Activation through Metabotropic Signaling Pathway. [PDF]

Biomol Ther (Seoul)
Kundu D, Wang M, Paudel S, Wang S, Jang CG, Kim KM.   +5 more
europepmc   +1 more source

Discovery of Thieno[3,2-<i>b</i>]pyridine-5-carboxamide and 2,3-Difluorobenzamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5. [PDF]

ACS Med Chem Lett
Crocker KE, Henderson SH, Capstick RA, Whomble DL, Bender AM, Felts AS, Han C, Engers JL, Billard NB, Maurer MA, Cho HP, Rodriguez AL, Niswender CM, O'Neill J, Watson KJ, Chang S, Blobaum AL, Boutaud O, Peng W, Rook JM, Conn PJ, Lindsley CW, Temple KJ.   +22 more
europepmc   +1 more source

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Cholesterol Localization around the Metabotropic Glutamate Receptor 2

The Journal of Physical Chemistry B, 2020
The metabotropic glutamate receptor (mGluR) 2 plays a key role in the central nervous system. mGluR2 has been shown to be regulated by its surrounding lipid environment, especially by cholesterol, by an unknown mechanism. Here, using a combination of biochemical approaches, photo-cross-linking experiments, and molecular dynamics simulations we show the
Rainer D. Beck, Camilo Aponte-Santamaría, Camilo Aponte-Santamaría, Alexandra Teslenko, Britta Brügger, Angelica Sandoval-Perez, Irmgard Sinning, Fabio Lolicato, Helman Amaya-Espinosa, Markus Kurth   +9 more
openaire   +3 more sources

Pharmacology of Metabotropic Glutamate Receptor 2 Homo‐ and Heterodimers

The FASEB Journal, 2020
Metabotropic Glutamate Receptors (mGluRs) are a family of class C g‐protein coupled receptors (GPCRs) that respond to glutamate as their native agonist. The eight members of the mGluR family are widely expressed across the nervous and are primarily charged with shaping and fine‐tuning neuronal excitability and synaptic efficacy. Like most class C GPCRs,
Paul J. Kammermeier, Tyler William McCullock   +1 more
openaire   +1 more source

Metabotropic Glutamate Receptor 2 Activators [PDF]

, 2014
Schizophrenia is a common and severe, often disabling psychiatric illness of unknown aetiology that affects approximately 24 million people worldwide. The illness is characterized by symptomatology comprising positive symptoms (hallucinations and delusional behaviours), negative symptoms (anhedonia, social withdrawal and apathy) and cognitive ...
José María Cid, Hilde Lavreysen, Andrés A. Trabanco   +2 more
openaire   +1 more source

LocaliZation of metabotropic glutamate receptor type 2 in the human brain

Neuroscience, 1999
Metabotropic glutamate receptors are a heterogeneous family of G-protein-coupled receptors that are linked to multiple second messenger systems to regulate neuronal excitability and synaptic transmission. To elucidate the physiological role of these receptors in human central nervous system function and dysfunction at the receptor protein level ...
Sarah J. Augood, Clive N. Svendsen, Henry J. Waldvogel, Piers C. Emson, Richard L.M. Faull, S. Rees, T. Phillips   +6 more
openaire   +3 more sources

Specificity of Metabotropic Glutamate Receptor 2 Coupling to G Proteins

Molecular Pharmacology, 2003
Metabotropic glutamate receptor 2 (mGluR2) is a class 3 G protein-coupled receptor and an important mediator of synaptic activity in the central nervous system. Previous work demonstrated that mGluR2 couples to pertussis toxin (PTX)-sensitive G proteins. However, the specificity of mGluR2 coupling to individual members of the G(i/o) family is not known.
Paul J. Kammermeier, Margaret I. Davis, Stephen R. Ikeda   +2 more
openaire   +3 more sources