Deletion of Type 2 Metabotropic Glutamate Receptor Decreases Sensitivity to Cocaine Reward in Rats [PDF]
Cell Reports, 2017 Cocaine users show reduced expression of the metabotropic glutamate receptor (mGluR2), but it is not clear whether this is a predisposing trait for addiction or a consequence of drug exposure.
Hong-Ju Yang +5 more
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Functional and Pharmacological Characteristics of Metabotropic Glutamate Receptors 2/4 Heterodimers [PDF]
Molecular Pharmacology, 2012 Metabotropic glutamate receptors (mGluRs) were thought until recently to function mainly as stable homodimers, but recent work suggests that heteromerization is possible. Despite the growth in available compounds targeting mGluRs, little is known about the pharmacological profile of mGluR heterodimers. Here, this question was addressed for the mGluR2/4
Paul J. Kammermeier
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The C Terminus of the Metabotropic Glutamate Receptor Subtypes 2 and 7 Specifies the Receptor Signaling Pathways [PDF]
Journal of Biological Chemistry, 2001 There is accumulating evidence that the specificity of the transduction cascades activated by G protein-coupled receptors cannot solely depend on the nature of the coupled G protein. To identify additional structural determinants, we studied two metabotropic glutamate (mGlu) receptors, the mGlu2 and mGlu7 receptors, that are both coupled to G(o ...
Julie Perroy +5 more
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Author Correction: SARS-CoV-2 uses metabotropic glutamate receptor subtype 2 as an internalization factor to infect cells [PDF]
Cell Discovery, 2021 Jinliang Wang +16 more
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Epigenetic upregulation of metabotropic glutamate receptor 2 in the spinal cord attenuates oestrogen-induced visceral hypersensitivity. [PDF]
Gut, 2015 Cao DY, Bai G, Ji Y, Traub RJ.
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Radiosynthesis and Evaluation of 11C-Labeled Isoindolone-Based Positive Allosteric Modulators for Positron Emission Tomography Imaging of Metabotropic Glutamate Receptor 2. [PDF]
ACS Pharmacol Transl SciLi Y +19 more
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Effectiveness of positive allosteric modulators of metabotropic glutamate receptor 2/3 (mGluR2/3) in animal models of schizophrenia. [PDF]
Transl PsychiatryOlivares-Berjaga D +6 more
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Journal of Neurochemistry, 2005 AbstractAntidepressant drugs have a clinical latency that correlates with the development of neuroadaptive changes, including down‐regulation of β‐adrenergic receptors in different brain regions. The identification of drugs that shorten this latency will have a great impact on the treatment of major depressive disorders.
Francesco Matrisciano +11 more
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Anticonvulsant action of metabotropic glutamate receptor agonists in DBA/2 mice.
Japanese Journal of Pharmacology, 1994 Yoshiko Horikawa +3 more
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