Radiosynthesis and Evaluation of 11C-Labeled Isoindolone-Based Positive Allosteric Modulators for Positron Emission Tomography Imaging of Metabotropic Glutamate Receptor 2. [PDF]
ACS Pharmacol Transl SciLi Y +19 more
europepmc +2 more sources
Metabotropic glutamate receptor subtype 2 is a receptor of SARS-CoV-2 [PDF]
, 2021 Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative pathogen of novel coronavirus disease 2019 (COVID-19)1. SARS-CoV-2 uses angiotensin converting enzyme 2 (ACE2) as a cellular receptor and enters cells via clathrin-mediated endocytosis (CME)2-4.
Zhigao Bu +16 more
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L-Glutamate supplementation improves small intestinal architecture and enhances the expressions of jejunal mucosa amino acid receptors and transporters in weaning piglets. [PDF]
PLoS ONE, 2014 L-Glutamate is a major oxidative fuel for the small intestine. However, few studies have demonstrated the effect of L-glutamate on the intestinal architecture and signaling of amino acids in the small intestine.
Meng Lin +7 more
doaj +1 more source
Repurposing Fragile X Drugs to Inhibit SARS-CoV-2 Viral Reproduction
Frontiers in Cell and Developmental Biology, 2020 The COVID-19 pandemic is a global health crisis that requires the application of interdisciplinary research to address numerous knowledge gaps including molecular strategies to prevent viral reproduction in affected individuals.
Cara J. Westmark +6 more
doaj +1 more source
Molecular Switches of Allosteric Modulation of the Metabotropic Glutamate 2 Receptor [PDF]
Structure, 2017 Metabotropic glutamate (mGlu) receptors are class C G protein-coupled receptors (GPCRs) crucial for CNS function and important drug discovery targets. Glutamate triggers receptor activation from an extracellular domain binding site while allosteric modulators bind in the seven-transmembrane domain.
Leonardo Pardo +8 more
openaire +4 more sources
Synergistic inhibition of survival, proliferation, and migration of U87 cells with a combination of LY341495 and Iressa. [PDF]
PLoS ONE, 2013 Glioblastomas exploit various molecular pathways to promote glutamate- dependent growth by activating the AMPA (2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl) propanoic acid) receptor, the group II metabotropic glutamate receptor, mGluR, and the epidermal ...
Zarina Yelskaya +5 more
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Neural Regeneration Research, 2021 Our previous studies have shown that glutamate and hippocampal neuron apoptosis are key signals and direct factors associated with diabetes-related depression, and structural and functional damage to the hippocampal neurovascular unit has been associated
Jian Liu +7 more
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ASN Neuro, 2009 A number of studies suggest that OLGs (oligodendrocytes), the myelinating cells of the central nervous system, are also a source of trophic molecules, such as neurotrophins that may influence survival of proximate neurons.
Issa P Bagayogo, Cheryl F Dreyfus
doaj +1 more source
Positive allosteric modulators of metabotropic glutamate 2 receptors in schizophrenia treatment [PDF]
Trends in Neurosciences, 2015 The past two decades have witnessed a rise in the 'NMDA receptor hypofunction' hypothesis for schizophrenia, a devastating disorder that affects around 1% of the population worldwide. A variety of presynaptic, postsynaptic, and regulatory proteins involved in glutamatergic signaling have thus been proposed as potential therapeutic targets.
Jason Younkin +4 more
openaire +3 more sources
Frontiers in Molecular Neuroscience, 2016 NMDA receptors are Ca2+-permeable ion channels. The activation of NMDA receptors requires agonist glutamate and co-agonist glycine. Recent evidence indicates that NMDA receptor also has metabotropic function.
Li-Jun Li +15 more
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