Results 31 to 40 of about 79,817 (291)

Abnormal Glu/mGluR2/3/PI3K pathway in the hippocampal neurovascular unit leads to diabetes-related depression

Neural Regeneration Research, 2021
Our previous studies have shown that glutamate and hippocampal neuron apoptosis are key signals and direct factors associated with diabetes-related depression, and structural and functional damage to the hippocampal neurovascular unit has been associated
Jian Liu, Yuan-Shan Han, Lin Liu, Lin Tang, Hui Yang, Pan Meng, Hong-Qing Zhao, Yu-Hong Wang   +7 more
doaj   +1 more source

Molecular Switches of Allosteric Modulation of the Metabotropic Glutamate 2 Receptor [PDF]

Structure, 2017
Metabotropic glutamate (mGlu) receptors are class C G protein-coupled receptors (GPCRs) crucial for CNS function and important drug discovery targets. Glutamate triggers receptor activation from an extracellular domain binding site while allosteric modulators bind in the seven-transmembrane domain.
Laura, Pérez-Benito, Maarten L J, Doornbos, Arnau, Cordomí, Luc, Peeters, Hilde, Lavreysen, Leonardo, Pardo, Gary, Tresadern   +6 more
openaire   +2 more sources

Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome [PDF]

, 2012
Fragile X syndrome, the most commonly known genetic cause of autism, is due to loss of the fragile X mental retardation protein, which regulates signal transduction at metabotropic glutamate receptor-5 in the brain.
DiPatrizio, Nicholas V., Frick, Andreas, Ginger, Melanie, Henstridge, Christopher M., Jung, Kwang-Mook, Katona, Istvan, Lassalle, Olivier, Mackie, Ken, Manzoni, Olivier J., Martin, Henry, Neuhofer, Daniela, Piomelli, Daniele, Sepers, Marja   +12 more
core   +6 more sources

Emotional Impairment and Persistent Upregulation of mGlu5 Receptor following Morphine Abstinence: Implications of an mGlu5-MOPr Interaction. [PDF]

, 2016
BACKGROUND: A difficult problem in treating opioid addicts is the maintenance of a drug-free state because of the negative emotional symptoms associated with withdrawal, which may trigger relapse.
Bailey, A, Chen, Y, Georgiou, P, Gonzalez, LR, Hourani, S, Kieffer, BL, Kitchen, I, Winsky-Sommerer, R, Zanos, P   +8 more
core   +1 more source

Group II metabotropic glutamate receptor type 2 allosteric potentiators prevent sodium lactate-induced panic-like response in panic-vulnerable rats [PDF]

, 2012
Rats with chronic inhibition of GABA synthesis by infusion of l-allyglycine, a glutamic acid decarboxylase inhibitor, into their dorsomedial/perifornical hypothalamus are anxious and exhibit panic-like cardio-respiratory responses to treatment with ...
Engleman, Eric A., Fitz, Stephanie D., Johnson, Philip L., Schkeryantz, Jeffrey M., Shekhar, Anantha, Svensson, Kjell A.   +5 more
core   +1 more source

Covalent Allosteric Probe for the Metabotropic Glutamate Receptor 2: Design, Synthesis, and Pharmacological Characterization. [PDF]

J Med Chem, 2019
Covalent labeling of G protein-coupled receptors (GPCRs) by small molecules is a powerful approach to understand binding modes, mechanism of action, pharmacology, and even facilitate structure elucidation. We report the first covalent positive allosteric modulator (PAM) for a class C GPCR, the mGlu2 receptor.
Doornbos MLJ, Wang X, Vermond SC, Peeters L, Pérez-Benito L, Trabanco AA, Lavreysen H, Cid JM, Heitman LH, Tresadern G, IJzerman AP.   +10 more
europepmc   +6 more sources

mGluR5 antagonism inhibits cocaine reinforcement and relapse by elevation of extracellular glutamate in the nucleus accumbens via a CB1 receptor mechanism. [PDF]

, 2018
Metabotropic glutamate receptor 5 (mGluR5) antagonism inhibits cocaine self-administration and reinstatement of drug-seeking behavior. However, the cellular and molecular mechanisms underlying this action are poorly understood.
Bi, Guo-Hua, Gardner, Eliot L, He, Yi, Jordan, Chloe J, Li, Jie, Li, Xia, Peng, Xiao-Qing, Xi, Zheng-Xiong, Yang, Hong-Ju, Zhang, Hai-Ying   +9 more
core   +2 more sources

Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain [PDF]

, 2017
Background: L-acetylcarnitine, a drug marketed for the treatment of chronic pain, causes analgesia by epigenetically up-regulating type-2 metabotropic glutamate (mGlu2) receptors in the spinal cord.
Battaglia, Giuseppe, Bernabucci, Matteo, Bruno, Valeria Maria Gloria, Cannella, Milena, Gradini, Roberto, Imbriglio, Tiziana, Mascio, Giada, Nicoletti, Ferdinando, Notartomaso, Serena, Scarselli, Pamela, Zappulla, Cristina   +10 more
core   +1 more source

Activation of the extracellular signal‐regulated kinase 2 by metabotropic glutamate receptors

European Journal of Neuroscience, 1999
AbstractActivation of metabotropic glutamate receptors (mGluRs) leads to modulation of a variety of second messenger pathways probably including the mitogen‐activated protein kinase (MAPK) extracellular signal‐regulated protein kinases (ERK). MAPK play a key role in the control of cellular responses to changes in the external environment by regulating ...
Francesco Ferraguti, Barbara Baldani‐Guerra, Mauro Corsi, Shigetada Nakanishi, Corrado Corti   +4 more
openalex   +4 more sources

Regulated Release of BDNF by Cortical Oligodendrocytes is Mediated Through Metabotropic Glutamate Receptors and the PLC Pathway

ASN Neuro, 2009
A number of studies suggest that OLGs (oligodendrocytes), the myelinating cells of the central nervous system, are also a source of trophic molecules, such as neurotrophins that may influence survival of proximate neurons.
Issa P Bagayogo, Cheryl F Dreyfus
doaj   +1 more source