Targeting mGlu5 metabotropic glutamate receptors in the treatment of cognitive dysfunction in a mouse model of phenylketonuria [PDF]
, 2018 We studied group-I metabotropic glutamate (mGlu) receptors in Pah(enu2) (ENU2) mice, which mimic the genetics and neurobiology of human phenylketonuria (PKU), a metabolic disorder characterized, if untreated, by autism, and intellectual disability (ID ...
Battaglia, Giuseppe +12 more
core +2 more sources
BMC Neuroscience, 2008 Background Many studies have focused on the implication of the serotonin and dopamine systems in neuroadaptive responses to the recreational drug 3,4-methylenedioxy-metamphetamine (MDMA).
Malki Rana +3 more
doaj +1 more source
Modeling T1 Resting-State MRI Variants Using Convolutional Neural Networks in Diagnosis of OCD [PDF]
arXiv, 2023 Obsessive-compulsive disorder (OCD) presents itself as a highly debilitating disorder. The disorder has common associations with the prefrontal cortex and the glutamate receptor known as Metabotropic Glutamate Receptor 5 (mGluR5). This receptor has been observed to demonstrate higher levels of signaling from positron emission tomography scans measured ...
arxiv
Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration [PDF]
, 2017 Neuroprotection is an unmet need in eye disorders characterized by retinal ganglion cell (RGC) death, such as prematurity-induced retinal degeneration, glaucoma, and age-related macular degeneration.
Battaglia, Giuseppe +10 more
core +1 more source
Antinociceptive actions of honokiol and magnolol on glutamatergic and inflammatory pain
Journal of Biomedical Science, 2009 The antinociceptive effects of honokiol and magnolol, two major bioactive constituents of the bark of Magnolia officinalis, were investigated on animal paw licking responses and thermal hyperalgesia induced by glutamate receptor agonists including ...
Ko Chien-Hsin +4 more
doaj +1 more source
Determinants of functional coupling between astrocytes and respiratory neurons in the pre-Bötzinger complex. [PDF]
PLoS ONE, 2011 Respiratory neuronal network activity is thought to require efficient functioning of astrocytes. Here, we analyzed neuron-astrocyte communication in the pre-Bötzinger Complex (preBötC) of rhythmic slice preparations from neonatal mice. In astrocytes that
Christian Schnell +2 more
doaj +1 more source
Direct imaging of lateral movements of AMPA receptors inside synapses [PDF]
EMBO J 22, 18 (15/09/2003) 4656-65, 2007 Trafficking of AMPA receptors in and out of synapses is crucial for synaptic plasticity. Previous studies have focused on the role of endo/exocytosis processes or that of lateral diffusion of extra-synaptic receptors. We have now directly imaged AMPAR movements inside and outside synapses of live neurons using single-molecule fluorescence microscopy ...
arxiv +1 more source
Metabotropic glutamate receptor 2/3 (mGluR2/3) activation suppresses TRPV1 sensitization in mouse, but not human sensory neurons [PDF]
, 2018 The use of human tissue to validate putative analgesic targets identified in rodents is a promising strategy for improving the historically poor translational record of preclinical pain research.
Baranger, David A.A. +5 more
core +2 more sources
mGluR5 Knockout mice exhibit normal conditioned place-preference to cocaine [PDF]
, 2012 Metabotropic glutamate receptor 5 (mGluR5) null mutant (-/-) mice have been reported to totally lack the rein- forcing or locomotor stimulating effects of cocaine. We tested mGluR5 -/- and +/+ mice for their locomotor and conditioned place- preference response to cocaine.
arxiv +1 more source
High- and low-conductance NMDA receptors are present in layer 4 spiny stellate and layer 2/3 pyramidal neurons of mouse barrel cortex [PDF]
Physiological Reports, 30th Dec. 2016, Vol. 4 no. e13051, 2016 NMDA receptors are ion channels activated by the neurotransmitter glutamate in the mammalian brain and are important in synaptic function and plasticity, but are also found in extrasynaptic locations and influence neuronal excitability. There are different NMDA receptor subtypes which differ in their single-channel conductance.
arxiv +1 more source