Results 1 to 10 of about 54,166 (228)

Structural basis of the activation of metabotropic glutamate receptor 3. [PDF]

Cell Res, 2022
Dear Editor, Glutamate is used by most synapses in the brain and responsible for fast excitatory transmission, thus playing impor- tant roles in excitotoxicity and ammonium detoxi fi cation in the brain.
Fang W, Yang F, Xu C, Ling S, Lin L, Zhou Y, Sun W, Wang X, Liu P, Rondard P, Shi P, Pin JP, Tian C, Liu J.   +13 more
europepmc   +4 more sources

Metabotropic glutamate receptor 3 as a potential therapeutic target for psychiatric and neurological disorders. [PDF]

Pharmacol Biochem Behav, 2022
Dogra S, Putnam J, Conn PJ.
europepmc   +4 more sources

Effects of metabotropic glutamate receptor 3 genotype on phonetic mismatch negativity. [PDF]

PLoS ONE, 2011
BACKGROUND: The genetic and molecular basis of glutamatergic dysfunction is one key to understand schizophrenia, with the identification of an intermediate phenotype being an essential step. Mismatch negativity (MMN) or its magnetic counterpart, magnetic
Yuki Kawakubo, Motomu Suga, Mamoru Tochigi, Masato Yumoto, Kenji Itoh, Tsukasa Sasaki, Yukiko Kano, Kiyoto Kasai   +7 more
doaj   +3 more sources

Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction. [PDF]

Proc Natl Acad Sci U S A, 2015
Walker AG, Wenthur CJ, Xiang Z, Rook JM, Emmitte KA, Niswender CM, Lindsley CW, Conn PJ.   +7 more
europepmc   +4 more sources

Negative allosteric modulators of metabotropic glutamate receptor 3 target the stem-like phenotype of glioblastoma [PDF]

Molecular Therapy: Oncolytics, 2021
Glioblastoma is an invariably deadly disease. A subpopulation of glioma stem-like cells (GSCs) drives tumor progression and treatment resistance. Two recent studies demonstrated that neurons form oncogenic glutamatergic electrochemical synapses with post-
Hans-Georg Wirsching, Manuela Silginer, Elisa Ventura, Will Macnair, Isabel Burghardt, Manfred Claassen, Silvia Gatti, Jürgen Wichmann, Claus Riemer, Hannah Schneider, Michael Weller   +10 more
doaj   +2 more sources

Effect of metabotropic glutamate receptor 3 genotype on N-acetylaspartate levels and neurocognition in non-smoking, active alcoholics [PDF]

Behavioral and Brain Functions, 2012
Background We studied the effects of single nucleotide polymorphisms (SNPs) in the metabotropic glutamate receptor 3 (GRM3) gene on brain N-acetylaspartate (NAA) concentrations and executive function (EF) skills in non-smoking, active alcoholics, and ...
Xia Yan, Ma Dongying, Hu Jian, Tang Chunling, Wu Zheng, Liu Lei, Xin Feng   +6 more
doaj   +2 more sources

Inhibition of metabotropic glutamate receptor III facilitates sensitization to alkylating chemotherapeutics in glioblastoma

Cell Death and Disease, 2021
Glioblastoma (GBM), the most malignant tumor of the central nervous system, is marked by its dynamic response to microenvironmental niches. In particular, this cellular plasticity contributes to the development of an immediate resistance during tumor ...
Julian P. Maier, Vidhya M. Ravi, Jan Kueckelhaus, Simon P. Behringer, Niklas Garrelfs, Paulina Will, Na Sun, Jasmin von Ehr, Jonathan M. Goeldner, Dietmar Pfeifer, Marie Follo, Luciana Hannibal, Axel Karl Walch, Ulrich G. Hofmann, Jürgen Beck, Dieter Henrik Heiland, Oliver Schnell, Kevin Joseph   +17 more
doaj   +2 more sources

Metabotropic glutamate receptor 1-mediated Ca2+ response is potentiated by activation of metabotropic glutamate receptor 3 in the rat hippocampal marginal zone

Brain Research Bulletin
Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors (GPCRs) that mediate slow glutamatergic signal transduction and regulate cell excitability in the central nervous system.
Megumi Taketo
doaj   +2 more sources

Glycine Release Is Upregulated by Metabotropic Glutamate Receptor 1 in Mouse Hippocampus [PDF]

Biomedicines
Background/Objectives: The neurotransmitter glycine is involved in several physiological and pathological conditions in the Central Nervous System. Different biological structures, including glycine receptors and transporters, are under study as targets ...
Luca Raiteri, Maria Cerminara, Aldamaria Puliti, Anna Pittaluga   +3 more
doaj   +2 more sources

Metabotropic glutamate receptor 3 is associated with heroin dependence but not depression or schizophrenia in a Chinese population. [PDF]

PLoS ONE, 2014
Metabotropic glutamate receptor subtype 3 (mGluR3, encoded by GRM3) plays important roles in the pathophysiology of schizophrenia, depression, and drug dependence.
Wei Jia, Rui Zhang, Bin Wu, Zun-xiao Dai, Yong-sheng Zhu, Ping-ping Li, Feng Zhu   +6 more
doaj   +2 more sources