Negative allosteric modulators of metabotropic glutamate receptor 3 target the stem-like phenotype of glioblastoma [PDF]
Molecular Therapy: Oncolytics, 2021 Glioblastoma is an invariably deadly disease. A subpopulation of glioma stem-like cells (GSCs) drives tumor progression and treatment resistance. Two recent studies demonstrated that neurons form oncogenic glutamatergic electrochemical synapses with post-
Hans-Georg Wirsching +10 more
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Glutamate Metabotropic Receptor Type 3 (mGlu3) Localization in the Rat Prelimbic Medial Prefrontal Cortex [PDF]
Frontiers in Neuroanatomy, 2022 Metabotropic glutamate receptors type 3 (mGlu3, encoded by GRM3) are increasingly related to cognitive functioning, including the working memory operations of the prefrontal cortex (PFC). In rhesus monkeys, mGlu3 are most commonly expressed on glia (36%),
Elizabeth Woo +2 more
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Journal of Pharmacological Sciences, 2012 Isolation-induced abnormal behaviors are useful animal models for assessing potential anti-psychotic drugs. This study examined the effect of MGS0028, a selective metabotropic glutamate 2/3 receptor agonist, on abnormal behaviors such as hyperactivity ...
Yukio Ago +10 more
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Effects of metabotropic glutamate receptor 3 genotype on phonetic mismatch negativity. [PDF]
PLoS ONE, 2011 BACKGROUND: The genetic and molecular basis of glutamatergic dysfunction is one key to understand schizophrenia, with the identification of an intermediate phenotype being an essential step. Mismatch negativity (MMN) or its magnetic counterpart, magnetic
Yuki Kawakubo +7 more
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Metabotropic glutamate receptor 3 is associated with heroin dependence but not depression or schizophrenia in a Chinese population. [PDF]
PLoS ONE, 2014 Metabotropic glutamate receptor subtype 3 (mGluR3, encoded by GRM3) plays important roles in the pathophysiology of schizophrenia, depression, and drug dependence.
Wei Jia +6 more
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Effect of metabotropic glutamate receptor 3 genotype on N-acetylaspartate levels and neurocognition in non-smoking, active alcoholics [PDF]
Behavioral and Brain Functions, 2012 Background We studied the effects of single nucleotide polymorphisms (SNPs) in the metabotropic glutamate receptor 3 (GRM3) gene on brain N-acetylaspartate (NAA) concentrations and executive function (EF) skills in non-smoking, active alcoholics, and ...
Xia Yan +6 more
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Neuropsychiatric Disease and Treatment, 2015 Xiaoqin Yang,1 Guiping Wang,2 Yaodong Wang,3 Xia Yue4 1Department of Bioinformatics, School of Life Science and Technology, Tongji University, Shanghai, 2Department of Pharmacy, College of Health Sciences, Guangzhou Medical University, 3Department of ...
Yang X, Wang G, Wang Y, Yue X
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Co-Activation of Metabotropic Glutamate Receptor 3 and Beta-Adrenergic Receptors Modulates Cyclic-AMP and Long-Term Potentiation, and Disrupts Memory Reconsolidation. [PDF]
Neuropsychopharmacology, 2017 Walker AG +13 more
europepmc +3 more sources
Neural Regeneration Research, 2021 Our previous studies have shown that glutamate and hippocampal neuron apoptosis are key signals and direct factors associated with diabetes-related depression, and structural and functional damage to the hippocampal neurovascular unit has been associated
Jian Liu +7 more
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The Role of Glutamate Receptors in Epilepsy
Biomedicines, 2023 Glutamate is an essential excitatory neurotransmitter in the central nervous system, playing an indispensable role in neuronal development and memory formation. The dysregulation of glutamate receptors and the glutamatergic system is involved in numerous
Tsang-Shan Chen +3 more
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