Results 91 to 100 of about 54,166 (228)

Developmental and Activity Dependent Regulation of Ionotropic Glutamate Receptors at Synapses

The Scientific World Journal, 2002
Glutamate receptors mediate the majority of excitatory responses in the central nervous system. The establishment and refinement of glutamatergic synaptic connections depend on the concerted actions of a-amino-3-hydroxy-5-methyl-isoxazole-4-propionate ...
Elek Molnar, John T.R. Isaac
doaj   +1 more source

Large‐scale case‐control study of a functional polymorphism in the glutamate receptor, metabotropic 3 gene in patients with schizophrenia [PDF]

, 2008
Ayako Nunokawa, Yuichiro Watanabe, Hideaki Kitamura, Naoshi Kaneko, Tadao Arinami, Hiroshi Ujike, Toshiya Inada, Nakao Iwata, Hiroshi Kunugi, Masanari Itokawa, Norio Ozaki, Toshiyuki Someya   +11 more
openalex   +1 more source

Ketamine Within Clinically Effective Range Inhibits Glutamate Transmission From Astrocytes to Neurons and Disrupts Synchronization of Astrocytic SICs

Frontiers in Cellular Neuroscience, 2019
BackgroundAstrocytes are now considered as crucial modulators of neuronal synaptic transmission. General anesthetics have been found to inhibit astrocytic activities, but it is not clear whether general anesthetics within the clinical concentration range
Yu Zhang, Yu Zhang, Sisi Wu, Liwei Xie, Shouyang Yu, Lin Zhang, Chengxi Liu, Wenjing Zhou, Tian Yu   +8 more
doaj   +1 more source

Molecular and Transcriptional Signatures of Gray Matter Volume Alterations Associated With Depressive Symptoms in Mild Cognitive Impairment

Human Brain Mapping, Volume 47, Issue 2, February 1, 2026.
Morphological alterations related to depressive symptoms in mild cognitive impairment were primarily involved in emotion and affective processing, showing strong correspondence with serotonergic, dopaminergic, and GABAergic systems and enrichment of genes associated with synaptic function and excitatory neurons.
Hu Xu, Yang Li, Chensi Li, Fenglin Xu, Yun Liu, Kehan Yan, Shiyi Chen, Wenxiu Song, Yifeng Luo, Yuefeng Li   +9 more
wiley   +1 more source

Effectiveness of positive allosteric modulators of metabotropic glutamate receptor 2/3 (mGluR2/3) in animal models of schizophrenia

Translational Psychiatry
Schizophrenia (SZ) is a deleterious brain disorder characterised by its heterogeneity and complex symptomatology consisting of positive, negative and cognitive deficits.
David Olivares-Berjaga, Albert Martínez-Pinteño, Natalia Rodríguez, Sergi Mas, Constanza Morén, Eduard Parellada, Patricia Gassó   +6 more
doaj   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

Peripheral Nerves in Cancer: Regulatory Roles and Therapeutic Strategies

MedComm, Volume 7, Issue 2, February 2026.
The interaction between cancer cells and peripheral nerves: (1) tumor cells could induce the growth of new neural axons and constructing a neural fiber network within the tumor tissue through secreting nerve growth factors; (2) nerve‐derived bioactive molecules can induce perineural invasion of tumor and regulate the malignant phenotype of tumor, such ...
Yan Fu, Zhi‐Shan Ge, Qing‐Yue Cao, Zi‐Han Li, An Zhang, Hai‐Dong Zhu, Gao‐Jun Teng   +6 more
wiley   +1 more source

The Calcium‐Binding Protein S100A10 (p11) Is Required for Normal Motor Performance by Regulating Vesicle Dynamics at Excitatory Synapses

Acta Physiologica, Volume 242, Issue 2, February 2026.
ABSTRACT Aim Identifying interactors in sensorimotor processing and neurotransmission remains a current challenge for understanding neural information processing and brain function. Methods To evaluate the role of p11 in sensorimotor processing and excitatory synaptic neurotransmission, neuron‐specific lentivirus‐directed p11 silencing, small ...
Esther Vilches‐Herrando, Guillermo Rodríguez‐Bey, Rosendo G. Hernández, Ángela Gento‐Caro, Ángel M. Pastor, Antonio Campos‐Caro, David González‐Forero, Bernardo Moreno‐López   +7 more
wiley   +1 more source

Troriluzole attenuates opioid intake, reinforcing efficacy, seeking behaviours, physical dependence and antinociceptive tolerance in rats

British Journal of Pharmacology, Volume 183, Issue 3, Page 505-519, February 2026.
Background and Purpose Riluzole, approved for amyotrophic lateral sclerosis (ALS), has a glutamate‐modulating profile favourable for mitigating opioid addiction. It reduces neuronal glutamate release and enhances glutamate reuptake, offering advantages over agents that only increase glutamate reuptake.
Ewa Galaj, Saadet Inan, Guo‐Hua Bi, Sonita Wiah, George Adamson, Allen B. Reitz, Zheng‐Xiong Xi, Scott M. Rawls   +7 more
wiley   +1 more source

Discovery of MGS0274, an ester prodrug of a metabotropic glutamate receptor 2/3 agonist with improved oral bioavailability

, 2020
Hiroki Urabe, Naoki Miyakoshi, Norikazu Ohtake, Akiko Nozoe, Motoki Ochi, Misako Fukasawa, Kohnosuke Kinoshita, Jun‐ichi Yamaguchi, Toshiyuki Marumo, Hirohiko Hikichi, Shigeyuki Chaki, Takashi Hashihayata   +11 more
openalex   +1 more source