Results 81 to 90 of about 53,434 (205)

Neurotransmitter modulation of extracellular H+ fluxes from isolated retinal horizontal cells of the skate

, 2004
Self-referencing H+-selective microelectrodes were used to measure extracellular H+ fluxes from horizontal cells isolated from the skate retina. A standing H+ flux was detected from quiescent cells, indicating a higher concentration of free hydrogen ions
Birnbaum, Andrea D., Hammar, Katherine, Malchow, Robert Paul, Molina, Anthony J.A, Smith, Peter J.S., Verzi, Michael P., Yamoah, Ebenezer N.   +6 more
core   +2 more sources

On the hierarchical classification of G Protein-Coupled Receptors [PDF]

, 2007
Motivation: G protein-coupled receptors (GPCRs) play an important role in many physiological systems by transducing an extracellular signal into an intracellular response. Over 50% of all marketed drugs are targeted towards a GPCR.
A. A. Freitas, A. Secker, Attwood, Bhasin, Bhasin, Bissantz, Cardoso, Christopoulos, D. R. Flower, Das, Davies, Flower, Flower, Foord, Gether, Gloriam, Guo, Horn, H  bert, J. Timmis, Karchin, Keerthi, Klabunde, Kolakowski, Lapinsh, M. Mendao, M. N. Davies, Milligan, Papasaikas, Prabhu, Sandberg, Schi  th   +31 more
core   +2 more sources

Progress toward therapeutic potential for AFQ056 in Fragile X syndrome

Journal of Experimental Pharmacology, 2013
Mary Sourial, Connie Cheng, Laurie C Doering Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada Abstract: Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and the leading ...
Sourial M, Cheng C, Doering LC
doaj  

Metabotropic glutamate receptor 3 as a potential therapeutic target for psychiatric and neurological disorders. [PDF]

Pharmacol Biochem Behav, 2022
Dogra S, Putnam J, Conn PJ.
europepmc   +1 more source

Structural basis of the activation of metabotropic glutamate receptor 3. [PDF]

Cell Res, 2022
Fang W, Yang F, Xu C, Ling S, Lin L, Zhou Y, Sun W, Wang X, Liu P, Rondard P, Shi P, Pin JP, Tian C, Liu J.   +13 more
europepmc   +1 more source

Modulation of the GABAergic pathway for the treatment of fragile X syndrome. [PDF]

, 2014
Fragile X syndrome (FXS) is the most common genetic cause of intellectual disability and the most common single-gene cause of autism. It is caused by mutations on the fragile X mental retardation gene (FMR1) and lack of fragile X mental retardation ...
Hagerman, Randi J, Hare, Emma B, Lozano, Reymundo   +2 more
core   +1 more source

Developmental and Activity Dependent Regulation of Ionotropic Glutamate Receptors at Synapses

The Scientific World Journal, 2002
Glutamate receptors mediate the majority of excitatory responses in the central nervous system. The establishment and refinement of glutamatergic synaptic connections depend on the concerted actions of a-amino-3-hydroxy-5-methyl-isoxazole-4-propionate ...
Elek Molnar, John T.R. Isaac
doaj   +1 more source

Plasticity of GABA(B) receptor-mediated heterosynaptic interactions at mossy fibers after status epilepticus [PDF]

, 2003
Several neurotransmitters, including GABA acting at presynaptic GABAB receptors, modulate glutamate release at synapses between hippocampal mossy fibers and CA3 pyramidal neurons.
Bowery, N.G., Chandler, K.E., Fabian-Fine, R., Kullmann, D.M., Princivalle, A.P., Walker, M.C.   +5 more
core  

mGluR5 knockout mice exhibit normal conditioned place-preference to cocaine [PDF]

, 2011
Metabotropic glutamate receptor 5 (mGluR5) null mutant (-/-) mice have been reported to totally lack the reinforcing or locomotor stimulating effects of cocaine.
Andrew L. Varnell, Donald C. Cooper, Melissa A. Fowler   +2 more
core   +2 more sources

Effectiveness of positive allosteric modulators of metabotropic glutamate receptor 2/3 (mGluR2/3) in animal models of schizophrenia

Translational Psychiatry
Schizophrenia (SZ) is a deleterious brain disorder characterised by its heterogeneity and complex symptomatology consisting of positive, negative and cognitive deficits.
David Olivares-Berjaga, Albert Martínez-Pinteño, Natalia Rodríguez, Sergi Mas, Constanza Morén, Eduard Parellada, Patricia Gassó   +6 more
doaj   +1 more source