Results 131 to 140 of about 50,881 (191)

Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacy

, 2016
Rocco D. Gogliotti, Darren W. Engers, Pedro M. Garcia-Barrantes, Joseph D. Panarese, Patrick R. Gentry, Anna L. Blobaum, Ryan D. Morrison, J. Scott Daniels, Analisa D. Thompson, Carrie K. Jones, P Jeffrey Conn, Colleen M. Niswender, Craig W. Lindsley, Corey R. Hopkins, Rocco D. Gogliotti, Darren W. Engers, Pedro M. Garcia-Barrantes, Joseph D. Panarese, Patrick R. Gentry, Anna L. Blobaum, Ryan D. Morrison, J. Scott Daniels, Analisa D. Thompson, Carrie K. Jones, P Jeffrey Conn, Colleen M. Niswender, Craig W. Lindsley, Corey R. Hopkins   +27 more
openalex   +2 more sources

Comprehensive mapping of the signaling events evoked by SARS-CoV-2 variants delta and omicron in human astrocytes. [PDF]

Sci Rep
Bhide K, Slavikova M, Talpasova L, Kuckova K, Klempa B, Tyagi P, Bhide M.   +6 more
europepmc   +1 more source

Synthesis and Metabotropic Glutamate Receptor Activity of S-Oxidized Variants of (−)-4-Amino-2-thiabicyclo-[3.1.0]hexane-4,6-dicarboxylate:  Identification of Potent, Selective, and Orally Bioavailable Agonists for mGlu2/3 Receptors

, 2006
James A. Monn, Steven M Massey, Matthew J. Valli, Steven S. Henry, Gregory A. Stephenson, Mark Bures, Marc Herin, John Catlow, Deborah Giera, Rebecca A. Wright, Bryan G. Johnson, Sherri L. Andis, Ann Kingston, Darryle D. Schoepp   +13 more
openalex   +1 more source

Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive allosteric modulators

, 2008
Colleen M. Niswender, Evan P. Lebois, Qingwei Luo, Kwang-Ho Kim, Hubert Muchalski, Huiyong Yin, P Jeffrey Conn, Craig W. Lindsley, Colleen M. Niswender, Evan P. Lebois, Qingwei Luo, Kwang-Ho Kim, Hubert Muchalski, Huiyong Yin, P Jeffrey Conn, Craig W. Lindsley   +15 more
openalex   +2 more sources

Early Oral Administration of D-Chiro-Inositol Reverses Hippocampal Insulin and Glutamate Signaling Deficits in the 3×Tg Humanized Mouse Model of Alzheimer's Disease. [PDF]

Nutrients
Pacheco-Sánchez B, Verheul-Campos J, Vargas A, Tovar R, Rodríguez-Pozo M, Navarro JA, López-Gambero AJ, Baixeras E, Serrano-Castro PJ, Suárez J, Sanjuan C, Rivera P, Rodríguez de Fonseca F.   +12 more
europepmc   +1 more source

Development of Novel, CNS Penetrant Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1 (mGlu₁), Based on an N-(3-Chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran-2-carboxamide Scaffold, That Potentiate Wild Type and Mutant mGlu₁ Receptors Found in Schizophrenics

, 2015
Garcia-Barrantes, Pedro M., Cho, Hyekyung P., Niswender, Colleen M., Byers, Frank W., Locuson, Charles W., Blobaum, Anna L., Xiang, Zixiu, Rook, Jerri M., Conn, P. Jeffrey, Lindsley, Craig W.   +9 more
openalex   +1 more source

Autoimmune encephalitis with Anti-mGluR1 antibodies: a comprehensive review. [PDF]

J Neurol
Chen Y, Xie L, Cui H, Zhang Y, Wu C, Qian W.   +5 more
europepmc   +1 more source

2,3-Ethylene- and 2,3-trimethylene-bridged analogues of the group III metabotropic glutamate receptor ligand 2-amino-4-phosphonobutanoic acid

, 2004
Rodney L. Johnson, Kolluri S S P Rao, Rodney L. Johnson, Kolluri S S P Rao   +3 more
openalex   +1 more source

Comparative Transcriptomics Provides Insight into the Neuroendocrine Regulation of Spawning in the Black-Lip Rock Oyster (<i>Saccostrea echinata</i>). [PDF]

Int J Mol Sci
Zafar MA, Suwansa-Ard S, Mellor A, Wingfield M, Reiher K, Elizur A, Cummins SF.   +6 more
europepmc   +1 more source

Aberrant hippocampal gamma oscillations in a mouse model of fragile X syndrome: insights from in vitro slice models. [PDF]

Mol Autism
Pollali E, Donaire DF, Ángel MD, Demiray YE, Lacalle SE, Hollnagel JO, Annamneedi A, Çalışkan G.   +7 more
europepmc   +1 more source