Results 161 to 170 of about 75,386 (292)
Endocannabinoid signaling modulates neurons of the pedunculopontine nucleus (PPN) via astrocytes. [PDF]
, 2014 The pedunculopontine nucleus (PPN) is known as the cholinergic part of the reticular activating system (RAS) and it plays an important role in transitions of slow-wave sleep to REM sleep and wakefulness.Antal, Miklós, Bíró, Tamás, Hegyi, Zoltán, Kovács, Adrienn, Kőszeghy, Áron, Pál, Balázs Zoltán, Szücs, Péter, Vincze, János +7 morecore 5-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-2,3′-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity
, 2004 Jeffrey Roppe, Bowei Wang, Dehua Huang, Lida Tehrani, Theodore M. Kamenecka, Edwin J. Schweiger, Jeffery J. Anderson, Jesse Brodkin, Xiaohui Jiang, Merryl Cramer, Janice Chung, Grace Reyes-Manalo, Benito Muñoz, Nicholas D. P. Cosford +13 moreopenalex +1 more sourceDiscovery, Synthesis, and Preclinical Characterization of N-(3-Chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine (VU0418506), a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4).
ACS Chemical Neuroscience, 2016 D. Engers, Anna L Blobaum, R. Gogliotti, Y. Cheung, J. M. Salovich, Pedro M Garcia-Barrantes, J. Daniels, R. Morrison, Carrie K Jones, M. Soars, X. Zhuo, Jeremy Hurley, J. Macor, J. Bronson, P. Conn, C. Lindsley, C. Niswender, C. Hopkins +17 moresemanticscholar +1 more sourcePreclinical and clinical study on type 3 metabotropic glutamate receptors in Parkinson’s disease
npj Parkinson's DiseaseMetabotropic glutamate (mGlu) receptors are candidate drug targets for therapeutic intervention in Parkinson’s disease (PD). Here we focused on mGlu3, a receptor subtype involved in synaptic regulation and neuroinflammation.Luisa Di Menna, Marika Alborghetti, Maria Ilenia De Bartolo, Marina Borro, Giovanna Gentile, Manuela Zinni, Matteo Bologna, Carolina Cutrona, Giovanna D’Errico, Tiziana Imbriglio, Domenico Bucci, Sara Merlo, Roxana Paula Ginerete, Rosamaria Orlando, Federica Carrillo, Giorgio Fortunato, Milena Cannella, Maria Angela Sortino, Julien Pansiot, Olivier Baud, Ferdinando Nicoletti, Valeria Bruno, Maurizio Simmaco, Francesco Ernesto Pontieri, Edoardo Bianchini, Domiziana Rinaldi, Amalia de Curtis, Giovanni De Gaetano, Licia Iacoviello, Teresa Esposito, Alfredo Berardelli, Giuseppe Battaglia +31 moredoaj +1 more sourceDevelopment of Novel, CNS Penetrant Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1 (mGlu1), Based on an N-(3-Chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran-2-carboxamide Scaffold, That Potentiate Wild Type and Mutant mGlu1 Receptors Found in Schizophrenics
, 2015 Pedro M. García-Barrantes, Hyekyung P. Cho, Colleen M. Niswender, Frank W. Byers, Charles W. Locuson, Anna L. Blobaum, Zixiu Xiang, Jerri M. Rook, P. Jeffrey Conn, Craig W. Lindsley +9 moreopenalex +1 more sourceDiscovery of 1-Butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1 H )-pyridone (JNJ-40411813): A Novel Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor
, 2014 José M. Cid, Gary Tresadern, Guillaume Duvey, Robert Lütjens, Terry Finn, Jean‐Philippe Rocher, Sonia Poli, Juan A. Vega, Ana Isabel de Lucas, Encarnación Matesanz, María Lourdes Linares, José Ignacio Andrés, Jesús Alcázar, José Manuel Alonso Segura, Gregor J. Macdonald, Daniel Oehlrich, Hilde Lavreysen, A. Ahnaou, Wilhelmus Drinkenburg, Claire Mackie, Stefan Pype, David J. Gallacher, Andrés A. Trabanco +22 moreopenalex +1 more sourcePHCCC, a Specific Enhancer of Type 4 Metabotropic Glutamate Receptors, Reduces Proliferation and Promotes Differentiation of Cerebellar Granule Cell Neuroprecursors [PDF]
, 2004 Anna M. Canudas, V. Di Giorgi-Gerevini, Luisa Iacovelli, Gian Mario Nano, Mara D’Onofrio, Antonietta Arcella, Felice Giangaspero, Carla L. Busceti, Lucia Ricci‐Vitiani, Giuseppe Battaglia, Ferdinando Nicoletti, Daniela Melchiorri +11 moreopenalex +1 more source
