Results 11 to 20 of about 50,881 (191)

A nanobody activating metabotropic glutamate receptor 4 discriminates between homo- and heterodimers. [PDF]

Proc Natl Acad Sci U S A, 2021
Significance Biologics, and especially antibodies, are promising therapeutics. Antibodies are expected to show higher subtype selectivity and less off-target activity than small molecules.
Haubrich J, Font J, Quast RB, Goupil-Lamy A, Scholler P, Nevoltris D, Acher F, Chames P, Rondard P, Prézeau L, Pin JP.   +10 more
europepmc   +4 more sources

The Metabotropic Glutamate Receptor 4 Positive Allosteric Modulator ADX88178 Inhibits Inflammatory Responses in Primary Microglia. [PDF]

J Neuroimmune Pharmacol, 2016
Ponnazhagan R, Harms AS, Thome AD, Jurkuvenaite A, Gogliotti R, Niswender CM, Conn PJ, Standaert DG.   +7 more
europepmc   +4 more sources

Aquaporin 4-Mediated Glutamate-Induced Astrocyte Swelling Is Partially Mediated through Metabotropic Glutamate Receptor 5 Activation

Frontiers in Cellular Neuroscience, 2017
Astrocytes are one of the most abundant cell types in the mammalian central nervous system (CNS), and astrocyte swelling is the primary event associated with brain edema.
Fang Yuan, Fang Yuan, Fang Yuan, Fang Yuan, Fang Yuan, Zhongfang Shi, Zhongfang Shi, Zhongfang Shi, Zhongfang Shi, Zhongfang Shi, Wei Zhang, Wei Zhang, Wei Zhang, Wei Zhang, Wei Zhang, Yang Lu, Yang Lu, Yang Lu, Yang Lu, Yang Lu, Yi Lu, Yi Lu, Yi Lu, Yi Lu, Yi Lu, Lixin Xu, Lixin Xu, Lixin Xu, Lixin Xu, Lixin Xu, Qing Fang, Qing Fang, Qing Fang, Qing Fang, Qing Fang, Min Wu, Min Wu, Min Wu, Min Wu, Min Wu, Mei Jia, Mei Jia, Mei Jia, Mei Jia, Mei Jia, Yujiao Wang, Yujiao Wang, Yujiao Wang, Yujiao Wang, Yujiao Wang, Liping Dong, Liping Dong, Liping Dong, Liping Dong, Liping Dong, Xu Yan, Xu Yan, Xu Yan, Xu Yan, Xu Yan, Shaohua Yang, Shaohua Yang, Shaohua Yang, Shaohua Yang, Shaohua Yang, Shaohua Yang   +65 more
doaj   +2 more sources

Characterization of the novel positive allosteric modulator of the metabotropic glutamate receptor 4 ADX88178 in rodent models of neuropsychiatric disorders. [PDF]

J Pharmacol Exp Ther, 2014
Kalinichev M, Le Poul E, Boléa C, Girard F, Campo B, Fonsi M, Royer-Urios I, Browne SE, Uslaner JM, Davis MJ, Raber J, Duvoisin R, Bate ST, Reynolds IJ, Poli S, Celanire S.   +15 more
europepmc   +4 more sources

Targeting metabotropic glutamate receptor 4 for cancer immunotherapy. [PDF]

Sci Adv, 2021
Immune cell–derived GRM4 negatively modulates antitumor immune response.
Wan Z, Sun R, Liu YW, Li S, Sun J, Li J, Zhu J, Moharil P, Zhang B, Ren P, Ren G, Zhang M, Ma X, Dai S, Yang D, Lu B, Li S.   +16 more
europepmc   +2 more sources

Interplay between metabotropic glutamate type 4 and adenosine type 1 receptors modulate synaptic transmission in the cerebellar cortex

Frontiers in Pharmacology
The synapses between parallel fibers and Purkinje cells play a pivotal role in cerebellar function. They are intricately governed by a variety of presynaptic receptors, notably by type 4 metabotropic glutamate (mGlu4) receptors and type 1 adenosine (A1 ...
Simon Bossi, Hervé Daniel, Heather McLean   +2 more
doaj   +2 more sources

Expression of metabotropic glutamate receptor 4 in osteosarcoma. [PDF]

Mol Clin Oncol, 2016
Metabotropic glutamate receptor 4 (mGluR4) has been associated with the pathogenesis of osteosarcoma. The aim of this study was to investigate mGluR4 expression and its clinical significance in osteosarcoma patients.
Wang S, Wei X, Chen B, Zhao M, Song G, Zhang Z, Li N.   +6 more
europepmc   +2 more sources

Dynamic modulation of inflammatory pain-related affective and sensory symptoms by optical control of amygdala metabotropic glutamate receptor 4

Molecular Psychiatry, 2018
C. Zussy, X. Gómez-Santacana, X. Rovira, D. Bundel, S. Ferrazzo, D. Bosch, Douglas Asede, F. Malhaire, F. Acher, J. Giraldo, E. Valjent, I. Ehrlich, F. Ferraguti, J. Pin, A. Llebaria, C. Goudet   +15 more
semanticscholar   +3 more sources

Allosteric modulation of group III metabotropic glutamate receptor 4: A potential approach to Parkinson's disease treatment

Proceedings of the National Academy of Sciences of the United States of America, 2003
M. Marino, David Williams, J. O'brien, O. Valenti, T. Mcdonald, Michelle K. Clements, Ruiping Wang, A. Dilella, J. Hess, G. Kinney, P. Conn   +10 more
semanticscholar   +2 more sources

Involvement of multiple taste receptors in umami taste: analysis of gustatory nerve responses in metabotropic glutamate receptor 4 knockout mice [PDF]

Journal of Physiology, 2015
K. Yasumatsu, Tomohiro Manabe, R. Yoshida, Ken Iwatsuki, H. Uneyama, I. Takahashi, Y. Ninomiya   +6 more
semanticscholar   +2 more sources