Results 11 to 20 of about 75,386 (292)

Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation

Nature Medicine, 2010
High amounts of glutamate are found in the brains of people with multiple sclerosis, an inflammatory disease marked by progressive demyelination. Glutamate might affect neuroinflammation via effects on immune cells. Knockout mice lacking metabotropic glutamate receptor-4 (mGluR4) were markedly vulnerable to experimental autoimmune encephalomyelitis ...
Francesca Fallarino, Claudia Volpi, Francesco Fazio, Serena Notartomaso, Carmine Vacca, Carla L. Busceti, Silvio Bicciato, Giuseppe Battaglia, Valeria Bruno, Paolo Puccetti, Maria C. Fioretti, Ferdinando Nicoletti, Ursula Grohmann, Roberto Di Marco   +13 more
semanticscholar   +9 more sources

Metabotropic Glutamate Receptor 4 [PDF]

Definitions, 2020
Metabotropic glutamate receptor 4 (912 aa, ~102 kDa) is encoded by the human GRM4 gene. This protein plays a role in the regulation of G protein-dependent signaling.

semanticscholar   +2 more sources

The metabotropic glutamate receptor 4 is internalized and desensitized upon protein kinase C activation [PDF]

British Journal of Pharmacology, 2006
The metabotropic glutamate receptor 4 (mGluR4) is a Gαi‐coupled receptor that modulates glutamatergic neurotransmission. As mGluR4 expression and activation have been implicated in a number of pathological conditions and because the internalization and desensitization properties of this receptor are poorly understood, studies were designed to ...
Jesper Mosolff Mathiesen, Martha Teresa Ramirez   +1 more
semanticscholar   +6 more sources

Involvement of multiple taste receptors in umami taste: analysis of gustatory nerve responses in metabotropic glutamate receptor 4 knockout mice [PDF]

Journal of Physiology, 2014
Keiko Yasumatsu, T. Manabe, Ryusuke Yoshida, Ken Iwatsuki, Hisayuki Uneyama, Ichiro Takahashi, Yuzo Ninomiya   +6 more
openalex   +2 more sources

The Metabotropic Glutamate Receptor 4 Positive Allosteric Modulator ADX88178 Inhibits Inflammatory Responses in Primary Microglia. [PDF]

J Neuroimmune Pharmacol, 2016
Ponnazhagan R, Harms AS, Thome AD, Jurkuvenaite A, Gogliotti R, Niswender CM, Conn PJ, Standaert DG.   +7 more
europepmc   +2 more sources

Glutamate metabotropic receptor 4 in breast cancer: a potential and specific target for chimeric antigen receptor therapy [PDF]

Frontiers in Oncology
BackgroundDespite the revolutionary success of chimeric antigen receptor (CAR) therapy in hematologic malignancies, its application in solid tumors is hindered by the scarcity of tumor-specific membrane antigens rigorously validated in clinical specimens.
Yien Xu, Yien Xu, Ayidana Hayierhan, Ayidana Hayierhan, Zexiao Chen, Zexiao Chen, Yumei Ma, Yumei Ma, Wenjun Zhang, Wenjun Zhang, Chaoliang Xu, Chaoliang Xu, Ruyi Mei, Ruyi Mei, Xiaoling Zhou, Xiaoling Zhou, Yuhao Zhu, Yuhao Zhu, Pingnan Sun, Pingnan Sun, Jundong Wu, Jundong Wu   +21 more
doaj   +2 more sources

Development and Antiparkinsonian Activity of VU0418506, a Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor 4 Homomers without Activity at mGlu2/4 Heteromers. [PDF]

ACS Chem Neurosci, 2016
Niswender CM, Jones CK, Lin X, Bubser M, Thompson Gray A, Blobaum AL, Engers DW, Rodriguez AL, Loch MT, Daniels JS, Lindsley CW, Hopkins CR, Javitch JA, Conn PJ.   +13 more
europepmc   +2 more sources

Distribution and synaptic localisation of the metabotropic glutamate receptor 4 (mGluR4) in the rodent CNS

Neuroscience, 2002
Corrado Corti, Laura Aldegheri, Péter Somogyi, Francesco Ferraguti   +3 more
openalex   +3 more sources

Metabotropic Glutamate Receptor 4 (mGlu4) Positive Allosteric Modulators Lack Efficacy in Rat and Marmoset Models of L-DOPA-Induced Dyskinesia. [PDF]

J Parkinsons Dis
Finlay CJ, Jackson MJ, Fisher R, Bundgaard C, Rose S, Duty S.   +5 more
europepmc   +3 more sources

Characterization of the novel positive allosteric modulator of the metabotropic glutamate receptor 4 ADX88178 in rodent models of neuropsychiatric disorders. [PDF]

J Pharmacol Exp Ther, 2014
Kalinichev M, Le Poul E, Boléa C, Girard F, Campo B, Fonsi M, Royer-Urios I, Browne SE, Uslaner JM, Davis MJ, Raber J, Duvoisin R, Bate ST, Reynolds IJ, Poli S, Celanire S.   +15 more
europepmc   +2 more sources