Results 21 to 30 of about 75,386 (292)

Modulation of Absence Seizures by the GABA_A Receptor: A Critical Role for Metabotropic Glutamate Receptor 4 (mGluR4) [PDF]

Journal of Neuroscience, 2000
O. Carter Snead, Pradeep Banerjee, W. McIntyre Burnham, David R. Hampson   +3 more
openalex   +2 more sources

Allosteric modulation of group III metabotropic glutamate receptor 4: A potential approach to Parkinson's disease treatment

Proceedings of the National Academy of Sciences of the United States of America, 2003
Michael J. Marino, David L. Williams, Julie A. O’Brien, Ornella Valenti, Terrence P. McDonald, Michelle K. Clements, Ruiping Wang, Anthony G. DiLella, J. Fred Hess, Gene G. Kinney, P. Jeffrey Conn   +10 more
openalex   +2 more sources

Discovery, Structure–Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4

Journal of Medicinal Chemistry, 2017
Delphine Charvin, Vincent Pomel, Millán Ortiz, Mélanie Frauli, Sophie Scheffler, Edith Steinberg, Luc Baron, Laurène Deshons, Rachel Rudigier, Delphine Thiarc, Christophe Morice, Baptiste Manteau, Stanislas Mayer, Danielle Graham, Bruno Giethlen, Nadia Brügger, Gaël Hédou, François Conquet, Stéphan Schann   +18 more
openalex   +3 more sources

Discovery and characterization of a novel series of N-phenylsulfonyl-1H-pyrrole picolinamides as positive allosteric modulators of the metabotropic glutamate receptor 4 (mGlu4). [PDF]

Bioorg Med Chem Lett, 2016
Gogliotti RD, Blobaum AL, Morrison RM, Daniels JS, Salovich JM, Cheung YY, Rodriguez AL, Loch MT, Conn PJ, Lindsley CW, Niswender CM, Hopkins CR.   +11 more
europepmc   +2 more sources

The Role of Glutamate Receptors in Epilepsy

Biomedicines, 2023
Glutamate is an essential excitatory neurotransmitter in the central nervous system, playing an indispensable role in neuronal development and memory formation. The dysregulation of glutamate receptors and the glutamatergic system is involved in numerous
Tsang-Shan Chen, Tzu-Hsin Huang, Ming-Chi Lai, Chin-Wei Huang   +3 more
doaj   +1 more source

Brain gamma rhythm and potential treatment of neurodegenerative disease

Journal of Neurorestoratology, 2020
In this mini-review, we illustrate the brain network oscillations in different brain areas, including the medial septal diagonal band complex (MSDB) and hippocampus, especially at gamma frequency bands (γ, 30–80 Hz) and theta frequency bands (θ, 4–12 Hz),
Jianhua Zhao, Ailin Du, Chengbiao Lu
doaj   +1 more source

L-Glutamate supplementation improves small intestinal architecture and enhances the expressions of jejunal mucosa amino acid receptors and transporters in weaning piglets. [PDF]

PLoS ONE, 2014
L-Glutamate is a major oxidative fuel for the small intestine. However, few studies have demonstrated the effect of L-glutamate on the intestinal architecture and signaling of amino acids in the small intestine.
Meng Lin, Bolin Zhang, Changning Yu, Jiaolong Li, Lin Zhang, Hui Sun, Feng Gao, Guanghong Zhou   +7 more
doaj   +1 more source

Actinin-4 Governs Dendritic Spine Dynamics and Promotes Their Remodeling by Metabotropic Glutamate Receptors [PDF]

Journal of Biological Chemistry, 2015
Dendritic spines are dynamic, actin-rich protrusions in neurons that undergo remodeling during neuronal development and activity-dependent plasticity within the central nervous system. Although group 1 metabotropic glutamate receptors (mGluRs) are critical for spine remodeling under physiopathological conditions, the molecular components linking ...
Magdalena Kalinowska, Andrés E. Chávez, Stefano Lutzu, Pablo E. Castillo, Feliksas F. Bukauskas, Anna Francesconi   +5 more
openalex   +4 more sources

Synergistic inhibition of survival, proliferation, and migration of U87 cells with a combination of LY341495 and Iressa. [PDF]

PLoS ONE, 2013
Glioblastomas exploit various molecular pathways to promote glutamate- dependent growth by activating the AMPA (2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl) propanoic acid) receptor, the group II metabotropic glutamate receptor, mGluR, and the epidermal ...
Zarina Yelskaya, Vangie Carrillo, Ewa Dubisz, Hira Gulzar, Devon Morgan, Shahana S Mahajan   +5 more
doaj   +1 more source

De novo assembly of the freshwater prawn Macrobrachium carcinus brain transcriptome for identification of potential targets for antibody development.

PLoS ONE, 2021
Crustaceans are major constituents of aquatic ecosystems and, as such, changes in their behavior and the structure and function of their bodies can serve as indicators of alterations in their immediate environment, such as those associated with climate ...
Jonathan L Crooke-Rosado, Sara C Diaz-Mendez, Yamil E Claudio-Roman, Nilsa M Rivera, Maria A Sosa   +4 more
doaj   +1 more source