Results 21 to 30 of about 50,881 (191)

Development and Antiparkinsonian Activity of VU0418506, a Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor 4 Homomers without Activity at mGlu2/4 Heteromers. [PDF]

ACS Chem Neurosci, 2016
Niswender CM, Jones CK, Lin X, Bubser M, Thompson Gray A, Blobaum AL, Engers DW, Rodriguez AL, Loch MT, Daniels JS, Lindsley CW, Hopkins CR, Javitch JA, Conn PJ.   +13 more
europepmc   +2 more sources

Discovery, Characterization, and Antiparkinsonian Effect of Novel Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4

Molecular Pharmacology, 2008
C. Niswender, Kari A. Johnson, C. Weaver, Carrie K Jones, Zixiu Xiang, Qingwei Luo, Alice L. Rodriguez, Joy Marlo, T. de Paulis, A. Thompson, Emily L. Days, Tasha Nalywajko, Cheryl A. Austin, Michael Baxter Williams, J. Ayala, R. Williams, C. Lindsley, P. Conn   +17 more
semanticscholar   +2 more sources

Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)) with oral efficacy in an antiparkins

Journal of Medicinal Chemistry, 2011
Carrie K Jones, D. Engers, A. Thompson, Julie R. Field, Anna L Blobaum, Stacey R. Lindsley, Ya Zhou, R. Gogliotti, S. Jadhav, Rocio Zamorano, J. Bogenpohl, Y. Smith, Ryan Morrison, J. Daniels, C. Weaver, P. Conn, C. Lindsley, C. Niswender, C. Hopkins   +18 more
semanticscholar   +2 more sources

Tricyclic thiazolopyrazole derivatives as metabotropic glutamate receptor 4 positive allosteric modulators.

Journal of Medicinal Chemistry, 2011
Sang-phyo Hong, Kevin G. Liu, Gil Ma, M. Sabio, M. Uberti, M. Bacolod, J. Peterson, Z. Zou, A. Robichaud, D. Doller   +9 more
semanticscholar   +2 more sources

Metabotropic Glutamate Receptor 4

Definitions, 2020
Metabotropic glutamate receptor 4 (912 aa, ~102 kDa) is encoded by the human GRM4 gene. This protein plays a role in the regulation of G protein-dependent signaling.

semanticscholar   +1 more source

De novo assembly of the freshwater prawn Macrobrachium carcinus brain transcriptome for identification of potential targets for antibody development.

PLoS ONE, 2021
Crustaceans are major constituents of aquatic ecosystems and, as such, changes in their behavior and the structure and function of their bodies can serve as indicators of alterations in their immediate environment, such as those associated with climate ...
Jonathan L Crooke-Rosado, Sara C Diaz-Mendez, Yamil E Claudio-Roman, Nilsa M Rivera, Maria A Sosa   +4 more
doaj   +1 more source

Molecular docking studies of N-substituted 4-methoxy-6-oxo-1-aryl-pyridazine-3-carboxamide derivatives as potential modulators of glutamate receptors [PDF]

Research Results in Pharmacology, 2020
Introduction: The virtual target-oriented screening is a necessary stage of modern drug-design. In the present study, the affinity of pyridazine derivatives for the most promising antiparkinsonian biotargets – I–III groups of metabotropic and ionotropic ...
Hanna I. Severina, Victoriya A. Georgiyants, Sergiy M. Kovalenko, Natalia V. Avdeeva, Artem I. Yarcev, Svetlana N. Prohoda   +5 more
doaj   +3 more sources

Participation of the Cholinergic System in Ameliorating Effect of Vasopressin Fragment by Group I Metabotropic Glutamate–Receptor Blockade

Journal of Pharmacological Sciences, 2008
The effect of [pGlu4,Cyt6,Arg8]-vasopressin fragment 4-9 (AVP4-9) on group I metabotropic glutamate (mGlu1) receptor antagonist–induced memory deficits was studied using 8-arm radial maze performance with 4 arms baited.
Tadatsugu Tarumi, Azusa Mikami, Kenichi Shimada, Chiaki Kamei   +3 more
doaj   +1 more source

Ionotropic glutamate receptors and their implications in cancer and cancer therapeutics

Biomedical and Biotechnology Research Journal, 2021
Glutamine, an excitatory neurotransmitter, is necessary for physiological as well as pathological processes. Other than neuronal disorders and/or cancers, glutamate receptors have also been associated with an array of other malignancies. The metabotropic
Shree Goyal, Pallab Chakraborty, Balasubramaniam Shankar   +2 more
doaj   +1 more source

Distribution and synaptic localisation of the metabotropic glutamate receptor 4 (mGluR4) in the rodent CNS

Neuroscience, 2002
C. Corti, L. Aldegheri, P. Somogyi, F. Ferraguti, F. Ferraguti, F. Ferraguti   +5 more
semanticscholar   +3 more sources