Results 51 to 60 of about 50,881 (191)

New 1,2,4-oxadiazole derivatives with positive mGlu4 receptor modulation activity and antipsychotic-like properties

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Considering the allosteric regulation of mGlu receptors for potential therapeutic applications, we developed a group of 1,2,4-oxadiazole derivatives that displayed mGlu4 receptor positive allosteric modulatory activity (EC50 = 282–656 nM).
Anna Stankiewicz, Katarzyna Kaczorowska, Ryszard Bugno, Aneta Kozioł, Maria H. Paluchowska, Grzegorz Burnat, Barbara Chruścicka, Paulina Chorobik, Piotr Brański, Joanna M. Wierońska, Beata Duszyńska, Andrzej Pilc, Andrzej J. Bojarski   +12 more
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Expression characteristics of metabotropic glutamate receptor 4 in cochlear hair cells during early postnatal stages in mice

陆军军医大学学报
‍Objective‍　‍To investigate the spatiotemporal expression pattern of metabotropic glutamate receptor 4 (mGluR4) in the mouse cochlear basilar membrane and its dynamic changes during postnatal development until hair cell synaptic maturation.
CHEN Zhiji, LIU Xuelai, ZHOU Xiaoqing
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Effects of acute versus repeated cocaine exposure on the expression of endocannabinoid signaling-related proteins in the mouse cerebellum

Frontiers in Integrative Neuroscience, 2014
Growing awareness of cerebellar involvement in addiction is based on the cerebellum’s intermediary position between motor and reward, potentially acting as an interface between motivational and cognitive functions.
Ana ePalomino, Francisco Javier ePavon, Eduardo eBlanco Calvo, Antonia eSerrano, Sergio eArrabal, Patricia eRivera, Antonio eVargas, Ainhoa eBilbao, Leticia eRubio, Fernando eRodriguez de Fonseca, Juan eSuarez   +10 more
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Bioactive Benzofuran Derivatives from Cortex Mori Radicis, and Their Neuroprotective and Analgesic Activities Mediated by mGluR1

Molecules, 2017
Four new benzofuran-type stilbene glycosides and 14 known compounds including 8 benzofuran-type stilbenes and 6 flavonoids were isolated from the traditional Chinese medicine, Cortex Mori Radicis.
Ya-Nan Wang, Mao-Feng Liu, Wei-Zhen Hou, Rui-Ming Xu, Jie Gao, An-Qi Lu, Mei-Ping Xie, Lan Li, Jian-Jun Zhang, Ying Peng, Li-Li Ma, Xiao-Liang Wang, Jian-Gong Shi, Su-Juan Wang   +13 more
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In Vitro Functional Characterization of GET73 as Possible Negative Allosteric Modulator of Metabotropic Glutamate Receptor 5

Frontiers in Pharmacology, 2018
The present study was aimed to further characterize the pharmacological profile of N-[4-(trifluoromethyl) benzyl]-4-methoxybutyramide (GET73), a putative negative allosteric modulator (NAM) of metabotropic glutamate subtype 5 receptor (mGluR5) under ...
Sarah Beggiato, Sarah Beggiato, Andrea C. Borelli, Andrea C. Borelli, Maria C. Tomasini, Maria C. Tomasini, M. Paola Castelli, M. Paola Castelli, Nicholas Pintori, Roberto Cacciaglia, Antonella Loche, Luca Ferraro, Luca Ferraro, Luca Ferraro   +13 more
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Developmental and Activity Dependent Regulation of Ionotropic Glutamate Receptors at Synapses

The Scientific World Journal, 2002
Glutamate receptors mediate the majority of excitatory responses in the central nervous system. The establishment and refinement of glutamatergic synaptic connections depend on the concerted actions of a-amino-3-hydroxy-5-methyl-isoxazole-4-propionate ...
Elek Molnar, John T.R. Isaac
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The Role of Canonical Transient Receptor Potential Channels in Seizure and Excitotoxicity

Cells, 2014
Canonical transient receptor potential (TRPC) channels are a family of polymodal cation channels with some degree of Ca2+ permeability. Although initially thought to be channels mediating store-operated Ca2+ influx, TRPC channels can be activated by ...
Fang Zheng, Kevin D. Phelan
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Neuroprotection and Functional Recovery Associated with Decreased Microglial Activation Following Selective Activation of mGluR2/3 Receptors in a Rodent Model of Parkinson's Disease

Parkinson's Disease, 2010
Clinical trials have demonstrated positive proof of efficacy of dual metabotropic glutamate receptor 2/3 (mGluR2/3) agonists in both anxiety and schizophrenia.
Hugh Chan, Helen Paur, Anthony C. Vernon, Virginia Zabarsky, Krishna P. Datla, Martin J. Croucher, David T. Dexter   +6 more
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FAM3A Protects Against Glutamate-Induced Toxicity by Preserving Calcium Homeostasis in Differentiated PC12 Cells

Cellular Physiology and Biochemistry, 2017
Background/Aims: Stroke is the leading cause of adult disability, and glutamate-induced dysregulation of intracellular Ca2+ homeostasis is a key mechanism.
Qing Song, Wen-Li Gou, Yu-Liang Zou
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Progress toward therapeutic potential for AFQ056 in Fragile X syndrome

Journal of Experimental Pharmacology, 2013
Mary Sourial, Connie Cheng, Laurie C Doering Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada Abstract: Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and the leading ...
Sourial M, Cheng C, Doering LC
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