Results 71 to 80 of about 50,881 (191)

Discovery, Structure-Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4.

Journal of Medicinal Chemistry, 2017
D. Charvin, V. Pomel, Millán Ortiz, Mélanie Frauli, Sophie Scheffler, Edith Steinberg, L. Baron, Laurène Deshons, Rachel Rudigier, Delphine Thiarc, Christophe Morice, Baptiste Manteau, Stanislas Mayer, Danielle L Graham, Bruno Giethlen, N. Brugger, Gael Hédou, F. Conquet, S. Schann   +18 more
semanticscholar   +1 more source

SAR study of a subtype selective allosteric potentiator of metabotropic glutamate 2 receptor, N-(4-phenoxyphenyl)-N-(3-pyridinylmethyl)ethanesulfonamide

, 2004
David A. Barda, Zhao-Qing Wang, Thomas C. Britton, Steven S. Henry, G. Erik Jagdmann, Darrell S. Coleman, Michael P. Johnson, Sherri L. Andis, Darryle D. Schoepp, David A. Barda, Zhao-Qing Wang, Thomas C. Britton, Steven S. Henry, G. Erik Jagdmann, Darrell S. Coleman, Michael P. Johnson, Sherri L. Andis, Darryle D. Schoepp   +17 more
openalex   +1 more source

Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity

, 2016
Mark D. Chappell, Renhua Li, Stephon C. Smith, Bruce A. Dressman, Eric G. Tromiczak, Allie E. Tripp, María-Jesús Blanco, Tatiana Vetman, Steven J. Quimby, James Matt, Thomas C. Britton, Adam M. Fivush, Jeffrey M. Schkeryantz, Daniel Mayhugh, Jon A Erickson, Mark G. Bures, Carlos Jaramillo, Mercedes Carpintero, José Eugenio de Diego, Mario Barberis, Susana García‐Cerrada, José F. Soriano, Stephen Antonysamy, Shane Atwell, Iain MacEwan, Bradley Condon, Christine Sougias, Jing Wang, Ai-ping Zhang, Kris Conners, Chris Groshong, Stephen R. Wasserman, John W. Koss, Jeffrey M. Witkin, Xia Li, Carl Overshiner, Keith A. Wafford, Wesley Seidel, Xu-Shan Wang, Beverly A. Heinz, Steven Swanson, John T. Catlow, David W. Bedwell, James A. Monn, Charles H. Mitch, Paul L. Ornstein   +45 more
openalex   +2 more sources

Functional and Pharmacological Characteristics of Metabotropic Glutamate Receptors 2/4 Heterodimers [PDF]

, 2012
Kammermeier, Paul J.
openalex   +1 more source

Discovery, Synthesis, and Preclinical Characterization of N-(3-Chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine (VU0418506), a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4).

ACS Chemical Neuroscience, 2016
D. Engers, Anna L Blobaum, R. Gogliotti, Y. Cheung, J. M. Salovich, Pedro M Garcia-Barrantes, J. Daniels, R. Morrison, Carrie K Jones, M. Soars, X. Zhuo, Jeremy Hurley, J. Macor, J. Bronson, P. Conn, C. Lindsley, C. Niswender, C. Hopkins   +17 more
semanticscholar   +1 more source

A new signalling pathway for parallel fibre presynaptic type 4 metabotropic glutamate receptors (mGluR4) in the rat cerebellar cortex

, 2012
Abitbol, Karine, McLean, Heather, Bessiron, Thomas, Daniel Hervé   +3 more
openalex   +2 more sources

Antagonist activity of α‐substituted 4‐carboxyphenylglycine analogues at group I metabotropic glutamate receptors expressed in CHO cells [PDF]

, 1999
Doherty, A J, Collingridge, G L, Jane, D E   +2 more
openalex   +1 more source

Elucidating the molecular logic of a metabotropic glutamate receptor heterodimer

Nature Communications
Metabotropic glutamate (mGlu) receptor protomers can heterodimerize, leading to different pharmacology compared to their homodimeric counterparts. Here, we use complemented donor-acceptor resonance energy transfer (CODA-RET) technology that distinguishes
Xin Lin, Davide Provasi, Colleen M. Niswender, Wesley B. Asher, Jonathan A. Javitch   +4 more
doaj   +1 more source

Synthesis and Evaluation in Monkey of [¹⁸F]4-Fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4-yl)thiazol-2-yl)benzamide ([¹⁸F]FIMX): A Promising Radioligand for PET Imaging of Brain Metabotropic Glutamate Receptor 1 (mGluR1)

, 2013
Rong Xu, Paolo Zanotti Fregonara, Sami S Zoghbi, Robert L. Gladding, Alicia E. Woock, Robert B. Innis, Victor W. Pike   +6 more
openalex   +2 more sources

Role of G Protein-coupled Receptor Kinase 4 and -Arrestin 1 in Agonist-stimulated Metabotropic Glutamate Receptor 1 Internalization and Activation of Mitogen-activated Protein Kinases [PDF]

, 2003
Luisa Iacovelli, Lorena Salvatore, Loredana Capobianco, Antonietta Picascia, Eliana Barletta, Marianna Storto, Stefania Mariggiò, Michele Sallese, Antonio Porcellini, Ferdinando Nicoletti, Antonio De Blasi, Luisa Iacovelli, Lorena Salvatore, Loredana Capobianco, Antonietta Picascia, Eliana Barletta, Marianna Storto, Michele Sallese, Antonio Porcellini, Ferdinando Nicoletti, Antonio De Blasi   +20 more
openalex   +1 more source