Results 81 to 90 of about 50,881 (191)
Preclinical and clinical study on type 3 metabotropic glutamate receptors in Parkinson’s disease
npj Parkinson's DiseaseMetabotropic glutamate (mGlu) receptors are candidate drug targets for therapeutic intervention in Parkinson’s disease (PD). Here we focused on mGlu3, a receptor subtype involved in synaptic regulation and neuroinflammation.Luisa Di Menna, Marika Alborghetti, Maria Ilenia De Bartolo, Marina Borro, Giovanna Gentile, Manuela Zinni, Matteo Bologna, Carolina Cutrona, Giovanna D’Errico, Tiziana Imbriglio, Domenico Bucci, Sara Merlo, Roxana Paula Ginerete, Rosamaria Orlando, Federica Carrillo, Giorgio Fortunato, Milena Cannella, Maria Angela Sortino, Julien Pansiot, Olivier Baud, Ferdinando Nicoletti, Valeria Bruno, Maurizio Simmaco, Francesco Ernesto Pontieri, Edoardo Bianchini, Domiziana Rinaldi, Amalia de Curtis, Giovanni De Gaetano, Licia Iacoviello, Teresa Esposito, Alfredo Berardelli, Giuseppe Battaglia +31 moredoaj +1 more sourceSynthesis and Pharmacological Characterization of 4-Substituted-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates: Identification of New Potent and Selective Metabotropic Glutamate 2/3 Receptor Agonists
, 2013 James A. Monn, Matthew J. Valli, Steven M Massey, Junliang Hao, Matthew R. Reinhard, Mark G. Bures, Beverly A. Heinz, Xushan Wang, Joan H. Carter, Brian G. Getman, Gregory A. Stephenson, Marc Herin, John T. Catlow, Steven Swanson, Bryan G. Johnson, David L McKinzie, Steven S. Henry +16 moreopenalex +1 more sourceDiscovery of N-(5-Fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (VU0424238): A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Selected for Clinical Evaluation
, 2017 Felts, AndrewS., Rodriguez, Alice L., Blobaum, Anna L., Morrison, Ryan D., Bates, Brittney S., Thompson Gray, Analisa, Rook, Jerri M., Tantawy, Mohammed N., Byers, Frank W., Chang, Sichen, Venable, Daryl F., Luscombe, Vincent B., Tamagnan, Gilles D., Niswender, Colleen M., Daniels, J. Scott, Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A., Felts, Andrew
S. +19 moreopenalex +1 more sourceDiscovery of Allosteric Potentiators for the Metabotropic Glutamate 2 Receptor: Synthesis and Subtype Selectivity of N-(4-(2-Methoxyphenoxy)phenyl)-N-(2,2,2− trifluoroethylsulfonyl)pyrid-3-ylmethylamine
, 2003 Michael P. Johnson, Melvyn Baez, G. Erik Jagdmann, Thomas C. Britton, Thomas H. Large, David O. Callagaro, Joseph P. Tizzano, James A. Monn, Darryle D. Schoepp +8 moreopenalex +1 more sourceProtective Role for Type 4 Metabotropic Glutamate Receptors against Ischemic Brain Damage [PDF]
, 2010 Moyanova, Slavianka G, Mastroiacovo, Federica, Kortenska, Lidia V, Mitreva, Rumiana G, Fardone, Erminia, Santolini, Ines, Sobrado, Mónica, Battaglia, Giuseppe, Bruno Valeria, Nicoletti Ferdinando, Ngomba, Richard T +10 moreopenalex +1 more sourceThe Metabotropic Glutamate Receptor 4-Positive Allosteric Modulator VU0364770 Produces Efficacy Alone and in Combination with l-DOPA or an Adenosine 2A Antagonist in Preclinical Rodent Models of Parkinson's Disease
Journal of Pharmacology and Experimental Therapeutics, 2012 Carrie K Jones, M. Bubser, A. Thompson, J. Dickerson, N. Turle-Lorenzo, M. Amalric, Anna L Blobaum, T. Bridges, R. Morrison, S. Jadhav, D. Engers, Kimberly Italiano, Jacob Bode, J. Daniels, C. Lindsley, C. Hopkins, P. Conn, C. Niswender +17 moresemanticscholar +1 more source[3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine Binding to Metabotropic Glutamate Receptor Subtype 5 in Rodent Brain: In Vitro and in Vivo Characterization
, 2002 Jeffery J. Anderson, Sara P. Rao, Blake Rowe, Darlene R. Giracello, Greg Holtz, Deborah F. Chapman, Lida Tehrani, Margaret J. Bradbury, Nicholas D.P. Cosford, Mark A. Varney, Jeffery J. Anderson, Sara P. Rao, Blake Rowe, Darlene R. Giracello, Greg Holtz, Deborah F. Chapman, Lida Tehrani, Margaret J. Bradbury, Nicholas D.P. Cosford, Mark A. Varney +19 moreopenalex +1 more sourceSynthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4)
, 2009 Williams Richard, Johnson, Kari A., Gentry, Patrick R., Niswender, Colleen M., Weaver, Charles D., Conn, P. Jeffrey, Lindsley, Craig W., Hopkins, Corey R. +7 moreopenalex +1 more source
