Metabotropic glutamate receptor 5 may be involved in macrophage plasticity. [PDF]
Biol Res, 2017 Background Macrophages are a functionally heterogeneous cell population and depending on microenvironments they polarize in two main groups: M1 and M2. Glutamic acid and glutamate receptors may participate in the regulation of macrophage plasticity.
Shanshiashvili L +4 more
europepmc +6 more sources
Anti-metabotropic glutamate receptor 5 encephalitis: Five case reports and literature review. [PDF]
Brain Behav, 2023 Objective To describe the clinical and radiological characteristics of anti‐metabotropic glutamate receptor 5 (mGluR5) encephalitis. Methods We reviewed the clinical data of five patients with anti‐mGluR5 encephalitis, and performed a literature review ...
Chen S +7 more
europepmc +2 more sources
Plasma endocannabinoids in cocaine dependence and their relation to cerebral metabotropic glutamate receptor 5 density. [PDF]
Transl Psychiatry, 2023 Animal models indicate that the endocannabinoid system (ECS) plays a modulatory role in stress and reward processing, both crucially impaired in addictive disorders.
Kroll SL +12 more
europepmc +2 more sources
Case Report: Guillain-Barré Syndrome Characterized by Severe Headache Associated With Metabotropic Glutamate Receptor 5 Antibody. [PDF]
Front Immunol, 2022 Autoantibodies to metabotropic glutamate receptor 5 (mGluR5) are known to be the cause of autoimmune encephalitis, particularly limbic encephalitis, closely related to Hodgkin’s lymphoma (HL).
Yan W, Zhao C, Zhang H, Hu Z, Wang C.
europepmc +2 more sources
Frontiers in Cellular Neuroscience, 2017 Astrocytes are one of the most abundant cell types in the mammalian central nervous system (CNS), and astrocyte swelling is the primary event associated with brain edema.
Zhong-fang Shi +12 more
semanticscholar +3 more sources
Encephalitis Associated to Metabotropic Glutamate Receptor 5 (mGluR5) Antibodies in Cerebrospinal Fluid. [PDF]
Front Immunol, 2018 A 68-years-old Hispanic man, complained of night sweats, low grade fewer, unexplained weight loss, and memory problems over 3 months. Abdominal tomography showed multiple intra-abdominal adenopathy and biopsy confirmed classic Hodgkin's lymphoma.
Guevara C +8 more
europepmc +2 more sources
The Metabotropic Glutamate 5 Receptor Modulates Extinction and Reinstatement of Methamphetamine-Seeking in Mice [PDF]
PLoS ONE, 2013 Methamphetamine (METH) is a highly addictive psychostimulant with no therapeutics registered to assist addicts in discontinuing use. Glutamatergic dysfunction has been implicated in the development and maintenance of addiction.
Rose Chesworth +3 more
openalex +3 more sources
Metabotropic glutamate receptor 5 knockout rescues obesity phenotype in a mouse model of Huntington's disease. [PDF]
Sci Rep, 2022 Obesity represents a global health problem and is characterized by metabolic dysfunctions and a low-grade chronic inflammatory state, which can increase the risk of comorbidities, such as atherosclerosis, diabetes and insulin resistance.
Santos RPM +12 more
europepmc +2 more sources
Frontiers in Neuroscience, 2015 In the present review, we deliver an overview of the involvement of metabotropic glutamate receptor 5 (mGluR5) activity and density in pathological anxiety, mood disorders and addiction.
S. Terbeck +3 more
semanticscholar +3 more sources
Nicotine Use and Metabotropic Glutamate Receptor 5 in Individuals With Major Depressive and Posttraumatic Stress Disorders. [PDF]
Chronic Stress (Thousand Oaks), 2023 Metabotropic glutamate receptor 5 (mGluR5) dysregulation has been implicated in the pathophysiology of many psychiatric disorders, as well as nicotine use and dependence.
Baldassarri SR +6 more
europepmc +2 more sources