Results 1 to 10 of about 51,164 (271)

Metabotropic glutamate receptor 5 in bulimia nervosa. [PDF]

Sci Rep, 2020
Bulimia nervosa (BN) shares central features with substance-related and addictive disorders. The metabotropic glutamate receptor subtype 5 (mGlu5) plays an important role in addiction.
Mihov Y, Treyer V, Akkus F, Toman E, Milos G, Ametamey SM, Johayem A, Hasler G.   +7 more
europepmc   +8 more sources

Metabotropic glutamate receptor 5 inhibits α-synuclein-induced microglia inflammation to protect from neurotoxicity in Parkinson's disease. [PDF]

J Neuroinflammation, 2021
Background Microglia activation induced by α-synuclein (α-syn) is one of the most important factors in Parkinson’s disease (PD) pathogenesis. However, the molecular mechanisms by which α-syn exerts neuroinflammation and neurotoxicity remain largely ...
Zhang YN, Fan JK, Gu L, Yang HM, Zhan SQ, Zhang H.   +5 more
europepmc   +3 more sources

Anti-metabotropic glutamate receptor 5 encephalitis: Five case reports and literature review. [PDF]

Brain Behav, 2023
Objective To describe the clinical and radiological characteristics of anti‐metabotropic glutamate receptor 5 (mGluR5) encephalitis. Methods We reviewed the clinical data of five patients with anti‐mGluR5 encephalitis, and performed a literature review ...
Chen S, Ren H, Lin F, Fan S, Cao Y, Zhao W, Guan H, Encephalitis Collaborative Group.   +7 more
europepmc   +2 more sources

Anti-metabotropic glutamate receptor 5 coexistent anti-N-methyl-D-aspartate receptor encephalitis: a case report and literature review. [PDF]

Front Immunol
Metabotropic glutamate receptor 5 (mGluR5) antibody encephalitis is an infrequent clinical disorder, initially reported in 2011 among two patients presenting with limbic encephalitis and Hodgkin’s lymphoma.
Gu Y, Xuan T, Li P, Zhou J, Wang Z.
europepmc   +2 more sources

Aquaporin 4-Mediated Glutamate-Induced Astrocyte Swelling Is Partially Mediated through Metabotropic Glutamate Receptor 5 Activation

Frontiers in Cellular Neuroscience, 2017
Astrocytes are one of the most abundant cell types in the mammalian central nervous system (CNS), and astrocyte swelling is the primary event associated with brain edema.
Fang Yuan, Fang Yuan, Fang Yuan, Fang Yuan, Fang Yuan, Zhongfang Shi, Zhongfang Shi, Zhongfang Shi, Zhongfang Shi, Zhongfang Shi, Wei Zhang, Wei Zhang, Wei Zhang, Wei Zhang, Wei Zhang, Yang Lu, Yang Lu, Yang Lu, Yang Lu, Yang Lu, Yi Lu, Yi Lu, Yi Lu, Yi Lu, Yi Lu, Lixin Xu, Lixin Xu, Lixin Xu, Lixin Xu, Lixin Xu, Qing Fang, Qing Fang, Qing Fang, Qing Fang, Qing Fang, Min Wu, Min Wu, Min Wu, Min Wu, Min Wu, Mei Jia, Mei Jia, Mei Jia, Mei Jia, Mei Jia, Yujiao Wang, Yujiao Wang, Yujiao Wang, Yujiao Wang, Yujiao Wang, Liping Dong, Liping Dong, Liping Dong, Liping Dong, Liping Dong, Xu Yan, Xu Yan, Xu Yan, Xu Yan, Xu Yan, Shaohua Yang, Shaohua Yang, Shaohua Yang, Shaohua Yang, Shaohua Yang, Shaohua Yang   +65 more
doaj   +2 more sources

Case Report: Guillain-Barré Syndrome Characterized by Severe Headache Associated With Metabotropic Glutamate Receptor 5 Antibody. [PDF]

Front Immunol, 2022
Autoantibodies to metabotropic glutamate receptor 5 (mGluR5) are known to be the cause of autoimmune encephalitis, particularly limbic encephalitis, closely related to Hodgkin’s lymphoma (HL).
Yan W, Zhao C, Zhang H, Hu Z, Wang C.
europepmc   +2 more sources

Plasma endocannabinoids in cocaine dependence and their relation to cerebral metabotropic glutamate receptor 5 density. [PDF]

Transl Psychiatry, 2023
Animal models indicate that the endocannabinoid system (ECS) plays a modulatory role in stress and reward processing, both crucially impaired in addictive disorders.
Kroll SL, Hulka LM, Kexel AK, Vonmoos M, Preller KH, Treyer V, Ametamey SM, Baumgartner MR, Boost C, Pahlisch F, Rohleder C, Leweke FM, Quednow BB.   +12 more
europepmc   +2 more sources

The role of metabotropic glutamate receptor 5 in the pathogenesis of mood disorders and addiction:Combining preclinical evidence with human Positron Emission Tomography (PET) studies

Frontiers in Neuroscience, 2015
In the present review, we deliver an overview of the involvement of metabotropic glutamate receptor 5 (mGluR5) activity and density in pathological anxiety, mood disorders and addiction.
Sylvia eTerbeck, Funda eAkkus, Laurence Paul Chesterman, Gregor eHasler   +3 more
doaj   +2 more sources

The metabotropic glutamate 5 receptor modulates extinction and reinstatement of methamphetamine-seeking in mice. [PDF]

PLoS ONE, 2013
Methamphetamine (METH) is a highly addictive psychostimulant with no therapeutics registered to assist addicts in discontinuing use. Glutamatergic dysfunction has been implicated in the development and maintenance of addiction.
Rose Chesworth, Robyn M Brown, Jee Hyun Kim, Andrew J Lawrence   +3 more
doaj   +3 more sources

Encephalitis Associated to Metabotropic Glutamate Receptor 5 (mGluR5) Antibodies in Cerebrospinal Fluid. [PDF]

Front Immunol, 2018
A 68-years-old Hispanic man, complained of night sweats, low grade fewer, unexplained weight loss, and memory problems over 3 months. Abdominal tomography showed multiple intra-abdominal adenopathy and biopsy confirmed classic Hodgkin's lymphoma.
Guevara C, Farias G, Silva-Rosas C, Alarcon P, Abudinen G, Espinoza J, Caro A, Angus-Leppan H, de Grazia J.   +8 more
europepmc   +2 more sources