Results 1 to 10 of about 74,984 (320)

Metabotropic glutamate receptor 5 in bulimia nervosa. [PDF]

Sci Rep, 2020
Bulimia nervosa (BN) shares central features with substance-related and addictive disorders. The metabotropic glutamate receptor subtype 5 (mGlu5) plays an important role in addiction.
Mihov Y, Treyer V, Akkus F, Toman E, Milos G, Ametamey SM, Johayem A, Hasler G.   +7 more
europepmc   +8 more sources

Allosteric activation of metabotropic glutamate receptor 5 [PDF]

Journal of Biomolecular Structure and Dynamics, 2019
Metabotropic glutamate receptor 5 (mGluR5) is a class C G protein-coupled receptor (GPCR) with both an extracellular ligand binding site and an allosteric intrahelical chamber located similarly to the orthosteric ligand binding site of Class A GPCRs ...
B. Jójárt, Z. Orgován, Á. Márki, Gáspár Pándy-Szekeres, G. Ferenczy, G. Keserű   +5 more
semanticscholar   +5 more sources

Anti‐metabotropic glutamate receptor 5 encephalitis: Five case reports and literature review [PDF]

Brain and Behavior, 2023
Objective To describe the clinical and radiological characteristics of anti‐metabotropic glutamate receptor 5 (mGluR5) encephalitis. Methods We reviewed the clinical data of five patients with anti‐mGluR5 encephalitis, and performed a literature review ...
Sixian Chen, Haitao Ren, Fuhong Lin, Siyuan Fan, Yuze Cao, Weili Zhao, Hongzhi Guan, the Encephalitis Collaborative Group   +7 more
doaj   +2 more sources

Metabotropic glutamate receptor 5 (mGluR5) regulates bladder nociception [PDF]

Molecular Pain, 2012
Background Interstitial cystitis/painful bladder syndrome (IC/PBS), is a severely debilitating chronic condition that is frequently unresponsive to conventional pain medications.
Crock Lara W, Stemler Kristina M, Song David G, Abbosh Philip, Vogt Sherri K, Qiu Chang-Shen, Lai H Henry, Mysorekar Indira U, Gereau IV Robert W   +8 more
doaj   +4 more sources

Metabotropic glutamate receptor 5 may be involved in macrophage plasticity [PDF]

Biological Research, 2017
Background Macrophages are a functionally heterogeneous cell population and depending on microenvironments they polarize in two main groups: M1 and M2. Glutamic acid and glutamate receptors may participate in the regulation of macrophage plasticity.
Lali Shanshiashvili, Elene Tsitsilashvili, Nino Dabrundashvili, Irine Kalandadze, David Mikeladze   +4 more
doaj   +4 more sources

Anti-metabotropic glutamate receptor 5 coexistent anti-N-methyl-D-aspartate receptor encephalitis: a case report and literature review [PDF]

Frontiers in Immunology
Metabotropic glutamate receptor 5 (mGluR5) antibody encephalitis is an infrequent clinical disorder, initially reported in 2011 among two patients presenting with limbic encephalitis and Hodgkin’s lymphoma.
Yixin Gu, Yixin Gu, Tingting Xuan, Tingting Xuan, Pankui Li, Pankui Li, Jing Zhou, Jing Zhou, Zhenhai Wang, Zhenhai Wang   +9 more
doaj   +2 more sources

Plasma endocannabinoids in cocaine dependence and their relation to cerebral metabotropic glutamate receptor 5 density [PDF]

Translational Psychiatry, 2023
Animal models indicate that the endocannabinoid system (ECS) plays a modulatory role in stress and reward processing, both crucially impaired in addictive disorders.
Sara L. Kroll, Lea M. Hulka, Ann-Kathrin Kexel, Matthias Vonmoos, Katrin H. Preller, Valerie Treyer, Simon M. Ametamey, Markus R. Baumgartner, Carola Boost, Franziska Pahlisch, Cathrin Rohleder, F. Markus Leweke, Boris B. Quednow   +12 more
doaj   +2 more sources

Aquaporin 4-Mediated Glutamate-Induced Astrocyte Swelling Is Partially Mediated through Metabotropic Glutamate Receptor 5 Activation

Frontiers in Cellular Neuroscience, 2017
Astrocytes are one of the most abundant cell types in the mammalian central nervous system (CNS), and astrocyte swelling is the primary event associated with brain edema.
Fang Yuan, Fang Yuan, Fang Yuan, Fang Yuan, Fang Yuan, Zhongfang Shi, Zhongfang Shi, Zhongfang Shi, Zhongfang Shi, Zhongfang Shi, Wei Zhang, Wei Zhang, Wei Zhang, Wei Zhang, Wei Zhang, Yang Lu, Yang Lu, Yang Lu, Yang Lu, Yang Lu, Yi Lu, Yi Lu, Yi Lu, Yi Lu, Yi Lu, Lixin Xu, Lixin Xu, Lixin Xu, Lixin Xu, Lixin Xu, Qing Fang, Qing Fang, Qing Fang, Qing Fang, Qing Fang, Min Wu, Min Wu, Min Wu, Min Wu, Min Wu, Mei Jia, Mei Jia, Mei Jia, Mei Jia, Mei Jia, Yujiao Wang, Yujiao Wang, Yujiao Wang, Yujiao Wang, Yujiao Wang, Liping Dong, Liping Dong, Liping Dong, Liping Dong, Liping Dong, Xu Yan, Xu Yan, Xu Yan, Xu Yan, Xu Yan, Shaohua Yang, Shaohua Yang, Shaohua Yang, Shaohua Yang, Shaohua Yang, Shaohua Yang   +65 more
doaj   +2 more sources

Glutamate Delta-1 Receptor Regulates Metabotropic Glutamate Receptor 5 Signaling in the Hippocampus [PDF]

Molecular Pharmacology, 2016
The delta family of ionotropic glutamate receptors consists of glutamate delta-1 (GluD1) and glutamate delta-2 receptors. We have previously shown that GluD1 knockout mice exhibit features of developmental delay, including impaired spine pruning and switch in the N-methyl-D-aspartate receptor subunit, which are relevant to autism and other ...
P. Suryavanshi, Subhash C. Gupta, Roopali Yadav, V. Kesherwani, Jinxu Liu, S. Dravid   +5 more
semanticscholar   +4 more sources

Metabotropic glutamate receptor 5 neuroimaging in schizophrenia [PDF]

Schizophrenia Research, 2017
The metabotropic glutamate receptor 5 (mGluR5) is a promising drug target for the treatment of schizophrenia. In this study, we compared mGluR5 distribution volume ration (DVR) in subjects with schizophrenia and healthy controls. Given our previous findings, we matched samples for gender, age, and smoking status.
F. Akkus, V. Treyer, S. Ametamey, A. Johayem, A. Buck, G. Hasler   +5 more
semanticscholar   +4 more sources