Anti‐metabotropic glutamate receptor 5 encephalitis: Five case reports and literature review [PDF]
Brain and Behavior, 2023 Objective To describe the clinical and radiological characteristics of anti‐metabotropic glutamate receptor 5 (mGluR5) encephalitis. Methods We reviewed the clinical data of five patients with anti‐mGluR5 encephalitis, and performed a literature review ...
Sixian Chen +7 more
doaj +4 more sources
Encephalitis Associated to Metabotropic Glutamate Receptor 5 (mGluR5) Antibodies in Cerebrospinal Fluid [PDF]
Frontiers in Immunology, 2018 A 68-years-old Hispanic man, complained of night sweats, low grade fewer, unexplained weight loss, and memory problems over 3 months. Abdominal tomography showed multiple intra-abdominal adenopathy and biopsy confirmed classic Hodgkin's lymphoma.
Carlos Guevara +10 more
doaj +4 more sources
Metabotropic Glutamate Receptor Subtype 5 in Alcohol-Induced Negative Affect [PDF]
Brain Sciences, 2019 Allosteric modulators of metabotropic glutamate 5 receptors (mGlu5 receptors) have been identified as a promising treatment to independently alleviate both negative affective states and ethanol-seeking and intake.
Chelsea R. Kasten +2 more
doaj +2 more sources
Anti-metabotropic glutamate receptor 5 coexistent anti-N-methyl-D-aspartate receptor encephalitis: a case report and literature review [PDF]
Frontiers in ImmunologyMetabotropic glutamate receptor 5 (mGluR5) antibody encephalitis is an infrequent clinical disorder, initially reported in 2011 among two patients presenting with limbic encephalitis and Hodgkin’s lymphoma.
Yixin Gu +9 more
doaj +2 more sources
Plasma endocannabinoids in cocaine dependence and their relation to cerebral metabotropic glutamate receptor 5 density [PDF]
Translational Psychiatry, 2023 Animal models indicate that the endocannabinoid system (ECS) plays a modulatory role in stress and reward processing, both crucially impaired in addictive disorders.
Sara L. Kroll +12 more
doaj +2 more sources
Case Report: Guillain-Barré Syndrome Characterized by Severe Headache Associated With Metabotropic Glutamate Receptor 5 Antibody [PDF]
Frontiers in Immunology, 2022 Autoantibodies to metabotropic glutamate receptor 5 (mGluR5) are known to be the cause of autoimmune encephalitis, particularly limbic encephalitis, closely related to Hodgkin’s lymphoma (HL).
Weiqian Yan +4 more
doaj +2 more sources
Metabotropic glutamate receptor 5 knockout rescues obesity phenotype in a mouse model of Huntington’s disease [PDF]
Scientific Reports, 2022 Obesity represents a global health problem and is characterized by metabolic dysfunctions and a low-grade chronic inflammatory state, which can increase the risk of comorbidities, such as atherosclerosis, diabetes and insulin resistance.
Rebeca P. M. Santos +12 more
doaj +2 more sources
Metabotropic glutamate receptor 5 inhibits α-synuclein-induced microglia inflammation to protect from neurotoxicity in Parkinson’s disease [PDF]
Journal of Neuroinflammation, 2021 Background Microglia activation induced by α-synuclein (α-syn) is one of the most important factors in Parkinson’s disease (PD) pathogenesis. However, the molecular mechanisms by which α-syn exerts neuroinflammation and neurotoxicity remain largely ...
Ya-Nan Zhang +5 more
doaj +2 more sources
The metabotropic glutamate 5 receptor modulates extinction and reinstatement of methamphetamine-seeking in mice. [PDF]
PLoS ONE, 2013 Methamphetamine (METH) is a highly addictive psychostimulant with no therapeutics registered to assist addicts in discontinuing use. Glutamatergic dysfunction has been implicated in the development and maintenance of addiction.
Rose Chesworth +3 more
doaj +3 more sources
Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5. [PDF]
ACS Chem Biol, 2022 Kampen S +10 more
europepmc +3 more sources