Metabotropic glutamate receptor 5 (mGluR5) regulates bladder nociception [PDF]
Molecular Pain, 2012 Background Interstitial cystitis/painful bladder syndrome (IC/PBS), is a severely debilitating chronic condition that is frequently unresponsive to conventional pain medications.
Crock Lara W +8 more
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Metabotropic glutamate receptor 5 may be involved in macrophage plasticity [PDF]
Biological Research, 2017 Background Macrophages are a functionally heterogeneous cell population and depending on microenvironments they polarize in two main groups: M1 and M2. Glutamic acid and glutamate receptors may participate in the regulation of macrophage plasticity.
Lali Shanshiashvili +4 more
doaj +4 more sources
Metabotropic glutamate receptor 5 in bulimia nervosa [PDF]
Scientific Reports, 2020 AbstractBulimia nervosa (BN) shares central features with substance-related and addictive disorders. The metabotropic glutamate receptor subtype 5 (mGlu5) plays an important role in addiction. Based on similarities between binge eating and substance-related and addictive disorders, we investigated mGlu5 in vivo in 15 female subjects with BN and 15 ...
Yoan Mihov +9 more
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Allosteric activation of metabotropic glutamate receptor 5 [PDF]
Journal of Biomolecular Structure and Dynamics, 2019 Metabotropic glutamate receptor 5 (mGluR5) is a class C G protein-coupled receptor (GPCR) with both an extracellular ligand binding site and an allosteric intrahelical chamber located similarly to the orthosteric ligand binding site of Class A GPCRs. Ligands binding to this ancestral site of mGluR5 can act as positive (PAM), negative (NAM) or silent ...
Balázs Jójárt +5 more
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Operant sensation seeking requires metabotropic glutamate receptor 5 (mGluR5). [PDF]
PLoS ONE, 2010 Pharmacological and genetic studies have suggested that the metabotropic glutamate receptor 5 (mGluR5) is critically involved in mediating the reinforcing effects of drugs of abuse, but not food. The purpose of this study was to use mGluR5 knockout (KO),
Christopher M Olsen +3 more
doaj +6 more sources
Metabotropic Glutamate Receptor Subtype 5 in Alcohol-Induced Negative Affect [PDF]
Brain Sciences, 2019 Allosteric modulators of metabotropic glutamate 5 receptors (mGlu5 receptors) have been identified as a promising treatment to independently alleviate both negative affective states and ethanol-seeking and intake.
Chelsea R. Kasten +2 more
doaj +4 more sources
The metabotropic glutamate 5 receptor modulates extinction and reinstatement of methamphetamine-seeking in mice. [PDF]
PLoS ONE, 2013 Methamphetamine (METH) is a highly addictive psychostimulant with no therapeutics registered to assist addicts in discontinuing use. Glutamatergic dysfunction has been implicated in the development and maintenance of addiction.
Rose Chesworth +3 more
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Erratum to: Metabotropic glutamate receptor 5 may be involved in macrophage plasticity [PDF]
Biological Research, 2017 Lali Shanshiashvili +4 more
doaj +4 more sources
The role of the metabotropic glutamate receptor 5 in nicotine addiction [PDF]
CNS Spectrums, 2020 AbstractThis review summarizes the evidence for the potential involvement of metabotropic glutamate receptor 5 (mGluR5) in the development of nicotine addiction. Nicotine is consumed worldwide and is highly addictive. Previous research has extensively investigated the role of dopamine in association with reward learning and addiction, which has ...
Sylvia Terbeck +7 more
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Metabotropic glutamate receptor 5 neuroimaging in schizophrenia [PDF]
Schizophrenia Research, 2017 The metabotropic glutamate receptor 5 (mGluR5) is a promising drug target for the treatment of schizophrenia. In this study, we compared mGluR5 distribution volume ration (DVR) in subjects with schizophrenia and healthy controls. Given our previous findings, we matched samples for gender, age, and smoking status.
Akkus, Funda +5 more
openaire +3 more sources