Results 111 to 120 of about 51,164 (271)

Elongation factor-2 phosphorylation in dendrites and the regulation of dendritic mRNA translation in neurons

Frontiers in Cellular Neuroscience, 2014
Neuronal activity results in long lasting changes in synaptic structure and function by regulating mRNA translation in dendrites. These activity dependent events yield the synthesis of proteins known to be important for synaptic modifications and diverse
Christopher eHeise, Fabrizio eGardoni, Lorenza eCulotta, Monica eDiLuca, Chiara eVerpelli, Carlo eSala, Carlo eSala   +6 more
doaj   +1 more source

Agonist- and Reflex-Evoked Internalization of Metabotropic Glutamate Receptor 5 in Enteric Neurons [PDF]

, 2000
Min‐Tsai Liu, Annette L. Kirchgessner
openalex   +1 more source

Selective Effects of Acutely Administered N‐Acetyl‐Cysteine in Rodent Models of Nicotine‐Conditioned Behaviours

Addiction Biology, Volume 30, Issue 9, September 2025.
ABSTRACT Chronic nicotine administration leads to neuroadaptations, an important process in nicotine and tobacco dependence for which treatments are limited. The cysteine pro‐drug, N‐acetyl‐cysteine (NAC), is a promising glutamatergic agent that has shown some clinical efficacy in reducing nicotine use in humans.
Kelsey Stoddart, Michael Davies, Jamie Oughton, Emma Malcolm, Shakir D. AlSharari, Mohammed Shoaib   +5 more
wiley   +1 more source

Dendritic and Axonal Targeting of Type 5 Metabotropic Glutamate Receptor Is Regulated by Homer1 Proteins and Neuronal Excitation [PDF]

, 2000
Fabrice Ango, Jean‐Philippe Pin, Jian Chen Tu, Bo Xiao, Paul F. Worley, Joël Bockaert, Laurent Fagni   +6 more
openalex   +1 more source

Developing HaloTag and SNAP‐Tag Chemical Inducers of Dimerization to Probe Receptor Oligomerization and Downstream Signaling

Angewandte Chemie International Edition, Volume 64, Issue 35, August 25, 2025.
Controlling protein interactions is key to studying signaling. Antibody methods have limits, but chemical inducers of dimerization (CIDs) using HaloTags and SNAP‐Tags offer precise control. We present CIDs to covalently link heteromers with varied linkers and a FRET‐based sensor.
Michael Trumpp, Blaise Gatin‐Fraudet, Kjell Bruckmann, Wiktor Burdzinski, Kilian Roßmann, Joshua Levitz, Petra Knaus, Jerome Jatzlau, Johannes Broichhagen   +8 more
wiley   +1 more source

Progress toward therapeutic potential for AFQ056 in Fragile X syndrome

Journal of Experimental Pharmacology, 2013
Mary Sourial, Connie Cheng, Laurie C Doering Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada Abstract: Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and the leading ...
Sourial M, Cheng C, Doering LC
doaj  

FAM3A Protects Against Glutamate-Induced Toxicity by Preserving Calcium Homeostasis in Differentiated PC12 Cells

Cellular Physiology and Biochemistry, 2017
Background/Aims: Stroke is the leading cause of adult disability, and glutamate-induced dysregulation of intracellular Ca2+ homeostasis is a key mechanism.
Qing Song, Wen-Li Gou, Yu-Liang Zou
doaj   +1 more source

Activation of Metabotropic Glutamate Receptor 5 Has Direct Excitatory Effects and Potentiates NMDA Receptor Currents in Neurons of the Subthalamic Nucleus [PDF]

, 2000
Hazar Awad, George W. Hubert, Yoland Smith, Allan I. Levey, P. Jeffrey Conn   +4 more
openalex   +1 more source

Aberrant Modular Dynamics of Functional Networks in Schizophrenia and Their Relationship With Neurotransmitter and Gene Expression Profiles

Human Brain Mapping, Volume 46, Issue 12, 15 August 2025.
By harmonizing resting‐state fMRI data from a relatively large multi‐site sample, this study reveals altered modular dynamics in schizophrenia. These alterations are associated with multiple neurotransmitter systems and transcriptomic profiles that are preferentially enriched for biological processes of transmembrane transport and brain development, as
Yi Zhen, Yaqian Yang, Yi Zheng, Zhiming Zheng, Hongwei Zheng, Shaoting Tang   +5 more
wiley   +1 more source

The role of metabotropic glutamate receptor 5 on the stromal cell-derived factor-1/CXCR4 system in oral cancer.

PLoS ONE, 2013
We have demonstrated that blocking CXCR4 may be a potent anti-metastatic therapy for CXCR4-related oral cancer. However, as CXCR4 antagonists are currently in clinical use to induce the mobilization of hematopoietic stem cells, continuous administration ...
Nobuyuki Kuribayashi, Daisuke Uchida, Makoto Kinouchi, Natsumi Takamaru, Tetsuya Tamatani, Hirokazu Nagai, Youji Miyamoto   +6 more
doaj   +1 more source