Results 111 to 120 of about 478,976 (349)

Formation and Stability of Synaptic Receptor Domains [PDF]

Phys. Rev. Lett. 106, 238104 (2011), 2010
Neurotransmitter receptor molecules, concentrated in postsynaptic domains along with scaffold and a number of other molecules, are key regulators of signal transmission across synapses. Employing experiment and theory, we develop a quantitative description of synaptic receptor domains in terms of a reaction-diffusion model.
arxiv   +1 more source

Light‐Activated Pharmacological Tools for Exploring the Cholinergic System

Medicinal Research Reviews, EarlyView.
ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni, Giulia Galli, Clelia Dallanoce, Marco De Amici, Pau Gorostiza, Carlo Matera   +5 more
wiley   +1 more source

The prion protein regulates glutamate-mediated Ca2+ entry and mitochondrial Ca2+ accumulation in neurons [PDF]

, 2017
The cellular prion protein (PrPC) whose conformational misfolding leads to the production of deadly prions, has a still-unclarified cellular function despite decades of intensive research.
Bertoli, Alessandro, Castellani, Angela, Giacomello, Marta, Lim, Dmitry, Mario, Agnese De, Massimino, Maria Lina, Peggion, Caterina, Sorgato, Maria Catia, Viviani, Francesca   +8 more
core   +1 more source

Conformational diversity in class C GPCR positive allosteric modulation

Nature Communications
The metabotropic glutamate receptors (mGlus) are class C G protein-coupled receptors (GPCR) that form obligate dimers activated by the major excitatory neurotransmitter L-glutamate.
Giuseppe Cannone, Ludovic Berto, Fanny Malhaire, Gavin Ferguson, Aurelien Fouillen, Stéphanie Balor, Joan Font-Ingles, Amadeu Llebaria, Cyril Goudet, Abhay Kotecha, Vinothkumar K.R., Guillaume Lebon   +11 more
doaj   +1 more source

Pharmacological treatments inhibiting levodopa-induced dyskinesias in MPTP-lesioned monkeys: brain glutamate biochemical correlates

Frontiers in Neurology, 2014
Antiglutamatergic drugs can relieve Parkinson’s disease (PD) symptoms and decrease L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesias (LID).
Nicolas eMorin, Nicolas eMorin, Thérèse eDi Paolo, Thérèse eDi Paolo   +3 more
doaj   +1 more source

Metabotropic glutamate receptor 5 binding in patients with obsessive-compulsive disorder [PDF]

The International Journal of Neuropsychopharmacology, 2014
Obsessive-compulsive disorder (OCD) is a disabling, mostly chronic, psychiatric condition with significant social and economic impairments and is a major public health issue. However, numerous patients are resistant to currently available pharmacological and psychological interventions.
Akkus, Funda, Terbeck, Sylvia, Ametamey, Simon M, Rufer, Michael, Treyer, Valerie, Burger, Cyrill, Johayem, Anass, Mancilla, Baltazar Gomez, Sovago, Judit, Buck, Alfred, Hasler, Gregor   +10 more
openaire   +4 more sources

Clickable Photoaffinity Ligands for Metabotropic Glutamate Receptor 5 Based on Select Acetylenic Negative Allosteric Modulators.

ACS Chemical Biology, 2016
G protein-coupled receptors (GPCRs) represent the largest class of current drug targets. In particular, small-molecule allosteric modulators offer substantial potential for selectively "tuning" GPCR activity.
K. Gregory, R. Velagaleti, D. Thal, Ryan M. Brady, A. Christopoulos, P. Conn, David J. Lapinsky   +6 more
semanticscholar   +1 more source

Recent Developments in the Optical Control of Adrenergic Signaling

Medicinal Research Reviews, EarlyView.
ABSTRACT Adrenoceptors (ARs) play a vital role in various physiological processes and are key therapeutic targets. The advent of optical control techniques, including optogenetics and photopharmacology, offers the potential to modulate AR signaling with precise temporal and spatial resolution. In this review, we summarize the latest advancements in the
Shuang Shi, Yangzhi Cao, Maikel Wijtmans, Henry F. Vischer, Rob Leurs   +4 more
wiley   +1 more source

Metabotropic Glutamate Receptor Activation in Cerebelar Purkinje Cells as Substrate for Adaptive Timing of the Classicaly Conditioned Eye Blink Response [PDF]

, 1995
To understand how the cerebellum adaptively times the classically conditioned nictitating membrane response (NMR), a model of the metabotropic glutamate receptor (mGluR) second messenger system in cerebellar Purkinje cells is constructed.
Bullock, Daniel, Fiala, John C., Grossberg, Stephen   +2 more
core   +1 more source

Astrocytes Control Neuronal Excitability in the Nucleus Accumbens

The Scientific World Journal, 2007
Though accumulating evidence shows that the metabotropic glutamate receptor 5 (mGluR5) mediates some of the actions of extracellular glutamate after cocaine use, the cellular events underlying this action are poorly understood.
Tommaso Fellin, Marcello D'Ascenzo, Philip G. Haydon   +2 more
doaj   +1 more source