Glia, Volume 73, Issue 7, Page 1349-1364, July 2025.Main Points Comprehensive analysis of cortical astrocyte gene expression across the lifespan. Profiling dynamic changes of key astrocyte genes reveals functional shifts. Astrocytes contribute to gene‐length‐dependent transcription decline in the aging brain.
Xiaoran Wei +2 more
wiley +1 more source
CHIMIA, 2012 Involvement of metabotropic glutamate receptor subtype 5 (mGluR5) in physiological and pathophysiological processes in the brain has been demonstrated, and hence mGluR5 has emerged as an important drug target. [11C]-ABP688 is clinically the most
Selena Milicevic Sephton +6 more
doaj +1 more source
Chemical sensing by cell-surface chemoreceptor arrays: the roles of receptor cooperativity and adaptation [PDF]
arXiv, 2012 Most sensory cells use cross-membrane chemoreceptors to detect chemical signals in the environment. The biochemical properties and spatial organization of chemoreceptors play important roles in achieving and maintaining sensitivity and accuracy of chemical sensing.
arxiv
Metabotropic Glutamate Receptor 5-Induced Phosphorylation of Extracellular Signal-Regulated Kinase in Astrocytes Depends on Transactivation of the Epidermal Growth Factor Receptor [PDF]
, 2001 Richard D. Peavy +3 more
openalex +1 more source
Glia, Volume 73, Issue 7, Page 1483-1501, July 2025.Main Points Multi‐omics reveal Annexin‐A2 (A2) and S100a10 (A10) as SCN astrocyte enriched proteins. Disrupting A2‐A10 complex elevates astrocyte Ca2+ and compromises SCN timekeeping. Astrocytic A2‐A10 is a critical control point for SCN network rhythms.
Andrew P. Patton +6 more
wiley +1 more source
Trisubstituted Imidazoles as Positive Modulators of Metabotropic Glutamate Receptor Subtype 5 [PDF]
ACS Medicinal Chemistry Letters, 2013 Summary: These two application claim a series of trisubstituted imidazoles that may provide treatment for a wide variety of diseases and disorders such as schizophrenia, cognitive decline, dementia, cognitive impairment, and Alzheimer’s disease. Important Compound Classes:
openaire +3 more sources
Effect of Aging on Gene Expression of Metabotropic Glutamate Receptor 5 and Glutamate Transporter‐1 in the Prefrontal Cortex of Schizophrenics [PDF]
, 2001 Hideho Shimada +3 more
openalex +1 more source
Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 1, July 2025.ABSTRACT The α7 nicotinic acetylcholine receptor (α7 nAChR) has emerged as a key target for treating cognitive dysfunction in neurological disorders such as Alzheimer's disease (AD) and schizophrenia. α7 nAChRs play essential roles in neurotransmission, neuroinflammation and synaptic plasticity, not only in neurons but also in glial cells, where they ...
Janus H. Magnussen
wiley +1 more source
Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor alpha-induced neurotoxicity in concert with microglial-derived fas ligand [PDF]
, 2005 Activated microglia may be detrimental to neuronal survival in a number of neurodegenerative diseases. Thus, strategies that reduce microglial neurotoxicity may have therapeutic benefit.
Jones, F +3 more
core
A Molecular Communication Perspective of Alzheimer's Disease: Impact of Amyloid Beta Oligomers on Glutamate Diffusion in the Synaptic Cleft [PDF]
arXivMolecular communication (MC) within the synaptic cleft is vital for neurotransmitter diffusion, a process critical to cognitive functions. In Alzheimer's Disease (AD), beta-amyloid oligomers (A$\beta$os) disrupt this communication, leading to synaptic dysfunction.
arxiv