Results 11 to 20 of about 55,471 (274)

Metabotropic glutamate receptor 5 (mGluR5) regulates bladder nociception [PDF]

Molecular Pain, 2012
Background Interstitial cystitis/painful bladder syndrome (IC/PBS), is a severely debilitating chronic condition that is frequently unresponsive to conventional pain medications.
Crock Lara W, Stemler Kristina M, Song David G, Abbosh Philip, Vogt Sherri K, Qiu Chang-Shen, Lai H Henry, Mysorekar Indira U, Gereau IV Robert W   +8 more
doaj   +3 more sources

Metabotropic glutamate receptor 5: a target for migraine therapy [PDF]

Annals of Clinical and Translational Neurology, 2016
Introduction Many patients suffering from migraine gain little relief from existing treatments partly because many existing acute and preventive therapies used in migraine have been adopted from other neurologic conditions such as depression or epilepsy.
Maggie W. Waung, Simon Akerman, Mark Wakefield, Charlotte Keywood, Peter J. Goadsby   +4 more
doaj   +3 more sources

Metabotropic glutamate receptor 5 may be involved in macrophage plasticity [PDF]

Biological Research, 2017
Background Macrophages are a functionally heterogeneous cell population and depending on microenvironments they polarize in two main groups: M1 and M2. Glutamic acid and glutamate receptors may participate in the regulation of macrophage plasticity.
Lali Shanshiashvili, Elene Tsitsilashvili, Nino Dabrundashvili, Irine Kalandadze, David Mikeladze   +4 more
doaj   +3 more sources

Allosteric activation of metabotropic glutamate receptor 5 [PDF]

Journal of Biomolecular Structure and Dynamics, 2019
Metabotropic glutamate receptor 5 (mGluR5) is a class C G protein-coupled receptor (GPCR) with both an extracellular ligand binding site and an allosteric intrahelical chamber located similarly to the orthosteric ligand binding site of Class A GPCRs. Ligands binding to this ancestral site of mGluR5 can act as positive (PAM), negative (NAM) or silent ...
Balázs Jójárt, Zoltán Orgován, Árpád Márki, Gáspár Pándy‐Szekeres, György G. Ferenczy, György M. Keserü   +5 more
openalex   +4 more sources

Apo-state structure of the metabotropic glutamate receptor 5 transmembrane domain obtained using a photoswitchable ligand. [PDF]

Protein Sci
Kondo Y, Hatton C, Cheng R, Trabuco M, Glover H, Bertrand Q, Stierli F, Seidel HP, Mason T, Sarma S, Tellkamp F, Kepa M, Dworkowski F, Mehrabi P, Hennig M, Standfuss J.   +15 more
europepmc   +3 more sources

Metabotropic glutamate receptor 5 in bulimia nervosa. [PDF]

Sci Rep, 2020
AbstractBulimia nervosa (BN) shares central features with substance-related and addictive disorders. The metabotropic glutamate receptor subtype 5 (mGlu5) plays an important role in addiction. Based on similarities between binge eating and substance-related and addictive disorders, we investigated mGlu5 in vivo in 15 female subjects with BN and 15 ...
Mihov Y, Treyer V, Akkus F, Toman E, Milos G, Ametamey SM, Johayem A, Hasler G.   +7 more
europepmc   +7 more sources

Metabotropic glutamate receptor 5 in conditioned taste aversion learning [PDF]

Neurobiology of Learning and Memory, 2009
In conditioned taste aversion (CTA), animals learn to avoid a flavored solution (conditioned stimulus, CS) previously paired with internal malaise (unconditioned stimulus, US). Metabotropic glutamate receptor 5 (mGlu5) has been implicated in learning and memory processes and is necessary for CTA.
Ágnes Simonyi, Péter Serfózó, Kyle E. Parker, Ashley K. Ramsey, Todd R. Schachtman   +4 more
openalex   +3 more sources

Operant sensation seeking requires metabotropic glutamate receptor 5 (mGluR5). [PDF]

PLoS ONE, 2010
Pharmacological and genetic studies have suggested that the metabotropic glutamate receptor 5 (mGluR5) is critically involved in mediating the reinforcing effects of drugs of abuse, but not food. The purpose of this study was to use mGluR5 knockout (KO),
Christopher M Olsen, Daniel S Childs, Gregg D Stanwood, Danny G Winder   +3 more
doaj   +1 more source

Metabotropic glutamate receptor 5 neuroimaging in schizophrenia [PDF]

Schizophrenia Research, 2017
The metabotropic glutamate receptor 5 (mGluR5) is a promising drug target for the treatment of schizophrenia. In this study, we compared mGluR5 distribution volume ration (DVR) in subjects with schizophrenia and healthy controls. Given our previous findings, we matched samples for gender, age, and smoking status.
Akkus, Funda, Treyer, Valerie, Ametamey, Simon M, Johayem, Anass, Buck, Alfred, Hasler, Gregor   +5 more
openaire   +2 more sources

The role of the metabotropic glutamate receptor 5 in nicotine addiction [PDF]

CNS Spectrums, 2020
AbstractThis review summarizes the evidence for the potential involvement of metabotropic glutamate receptor 5 (mGluR5) in the development of nicotine addiction. Nicotine is consumed worldwide and is highly addictive. Previous research has extensively investigated the role of dopamine in association with reward learning and addiction, which has ...
Akkus, Funda, Terbeck, Sylvia, Haggarty, Connor J, Treyer, Valerie, Dietrich, Janan Janine, Hornschuh, Stefanie, Hasler, Gregor   +6 more
openaire   +3 more sources