Results 11 to 20 of about 54,947 (233)

Apo-state structure of the metabotropic glutamate receptor 5 transmembrane domain obtained using a photoswitchable ligand. [PDF]

Protein Sci
Kondo Y, Hatton C, Cheng R, Trabuco M, Glover H, Bertrand Q, Stierli F, Seidel HP, Mason T, Sarma S, Tellkamp F, Kepa M, Dworkowski F, Mehrabi P, Hennig M, Standfuss J.   +15 more
europepmc   +3 more sources

Operant sensation seeking requires metabotropic glutamate receptor 5 (mGluR5). [PDF]

PLoS ONE, 2010
Pharmacological and genetic studies have suggested that the metabotropic glutamate receptor 5 (mGluR5) is critically involved in mediating the reinforcing effects of drugs of abuse, but not food. The purpose of this study was to use mGluR5 knockout (KO),
Christopher M Olsen, Daniel S Childs, Gregg D Stanwood, Danny G Winder   +3 more
doaj   +1 more source

Metabotropic glutamate receptor 5 (mGluR5) regulates white adipocyte browning [PDF]

Jichu yixue yu linchuang, 2021
Objective To investigate whether mGluR5 could regulate white adipocytes browning. Methods Western blot was used to test the expression of mGluR5 in white and brown adipose tissue. Lipid droplets morphology was microscoped after BODIPY staining.
LUO Xie, ZENG Li, YUAN Lei
doaj  

Association of genetic variants of Glutamate Metabotropic Receptor 5 gene and state-anhedonia

European Psychiatry, 2022
Introduction Andedonia is one of the core symptoms of depression. It is known that in case of depressed individuals experiencing anhedonia, the classical antidepressants are often ineffective, thus investigation of this symptom would be essential ...
D. Török, X. Gonda, Z. Gal, N. Eszlari, G. Bagdy, G. Juhasz, P. Petschner   +6 more
doaj   +1 more source

Repurposing Fragile X Drugs to Inhibit SARS-CoV-2 Viral Reproduction

Frontiers in Cell and Developmental Biology, 2020
The COVID-19 pandemic is a global health crisis that requires the application of interdisciplinary research to address numerous knowledge gaps including molecular strategies to prevent viral reproduction in affected individuals.
Cara J. Westmark, Maki Kiso, Peter Halfmann, Pamela R. Westmark, Yoshihiro Kawaoka, Yoshihiro Kawaoka, Yoshihiro Kawaoka   +6 more
doaj   +1 more source

The Role of Glutamate Receptors in Epilepsy

Biomedicines, 2023
Glutamate is an essential excitatory neurotransmitter in the central nervous system, playing an indispensable role in neuronal development and memory formation. The dysregulation of glutamate receptors and the glutamatergic system is involved in numerous
Tsang-Shan Chen, Tzu-Hsin Huang, Ming-Chi Lai, Chin-Wei Huang   +3 more
doaj   +1 more source

Metabotropic glutamate receptor 5 (mGluR5) regulates bladder nociception

Molecular Pain, 2012
Background Interstitial cystitis/painful bladder syndrome (IC/PBS), is a severely debilitating chronic condition that is frequently unresponsive to conventional pain medications.
Crock Lara W, Stemler Kristina M, Song David G, Abbosh Philip, Vogt Sherri K, Qiu Chang-Shen, Lai H Henry, Mysorekar Indira U, Gereau IV Robert W   +8 more
doaj   +1 more source

Emotional Impairment and Persistent Upregulation of mGlu5 Receptor following Morphine Abstinence: Implications of an mGlu5-MOPr Interaction. [PDF]

, 2016
BACKGROUND: A difficult problem in treating opioid addicts is the maintenance of a drug-free state because of the negative emotional symptoms associated with withdrawal, which may trigger relapse.
Bailey, A, Chen, Y, Georgiou, P, Gonzalez, LR, Hourani, S, Kieffer, BL, Kitchen, I, Winsky-Sommerer, R, Zanos, P   +8 more
core   +1 more source

Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome [PDF]

, 2012
Fragile X syndrome, the most commonly known genetic cause of autism, is due to loss of the fragile X mental retardation protein, which regulates signal transduction at metabotropic glutamate receptor-5 in the brain.
DiPatrizio, Nicholas V., Frick, Andreas, Ginger, Melanie, Henstridge, Christopher M., Jung, Kwang-Mook, Katona, Istvan, Lassalle, Olivier, Mackie, Ken, Manzoni, Olivier J., Martin, Henry, Neuhofer, Daniela, Piomelli, Daniele, Sepers, Marja   +12 more
core   +5 more sources

Synergistic inhibition of survival, proliferation, and migration of U87 cells with a combination of LY341495 and Iressa. [PDF]

PLoS ONE, 2013
Glioblastomas exploit various molecular pathways to promote glutamate- dependent growth by activating the AMPA (2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl) propanoic acid) receptor, the group II metabotropic glutamate receptor, mGluR, and the epidermal ...
Zarina Yelskaya, Vangie Carrillo, Ewa Dubisz, Hira Gulzar, Devon Morgan, Shahana S Mahajan   +5 more
doaj   +1 more source