Results 11 to 20 of about 51,164 (271)
Metabotropic glutamate receptor 5 (mGluR5) regulates bladder nociception [PDF]
Molecular Pain, 2012 Background Interstitial cystitis/painful bladder syndrome (IC/PBS), is a severely debilitating chronic condition that is frequently unresponsive to conventional pain medications.
Crock Lara W +8 more
doaj +4 more sources
Allosteric activation of metabotropic glutamate receptor 5 [PDF]
Journal of Biomolecular Structure and Dynamics, 2019 Metabotropic glutamate receptor 5 (mGluR5) is a class C G protein-coupled receptor (GPCR) with both an extracellular ligand binding site and an allosteric intrahelical chamber located similarly to the orthosteric ligand binding site of Class A GPCRs ...
B. Jójárt +5 more
semanticscholar +5 more sources
Operant sensation seeking requires metabotropic glutamate receptor 5 (mGluR5). [PDF]
PLoS ONE, 2010 Pharmacological and genetic studies have suggested that the metabotropic glutamate receptor 5 (mGluR5) is critically involved in mediating the reinforcing effects of drugs of abuse, but not food. The purpose of this study was to use mGluR5 knockout (KO),
Christopher M Olsen +3 more
doaj +6 more sources
Metabotropic glutamate receptor 5 may be involved in macrophage plasticity [PDF]
Biological Research, 2017 Background Macrophages are a functionally heterogeneous cell population and depending on microenvironments they polarize in two main groups: M1 and M2. Glutamic acid and glutamate receptors may participate in the regulation of macrophage plasticity.
Lali Shanshiashvili +4 more
doaj +4 more sources
Metabotropic Glutamate Receptor Subtype 5 in Alcohol-Induced Negative Affect [PDF]
Brain Sciences, 2019 Allosteric modulators of metabotropic glutamate 5 receptors (mGlu5 receptors) have been identified as a promising treatment to independently alleviate both negative affective states and ethanol-seeking and intake.
Chelsea R. Kasten +2 more
doaj +4 more sources
Metabotropic glutamate receptor 5 knockout rescues obesity phenotype in a mouse model of Huntington's disease. [PDF]
Sci Rep, 2022 Obesity represents a global health problem and is characterized by metabolic dysfunctions and a low-grade chronic inflammatory state, which can increase the risk of comorbidities, such as atherosclerosis, diabetes and insulin resistance.
Santos RPM +12 more
europepmc +2 more sources
Metabotropic glutamate receptor 5: a target for migraine therapy [PDF]
Annals of Clinical and Translational Neurology, 2016 Many patients suffering from migraine gain little relief from existing treatments partly because many existing acute and preventive therapies used in migraine have been adopted from other neurologic conditions such as depression or epilepsy.
Maggie W. Waung +4 more
semanticscholar +4 more sources
Biased agonism and allosteric modulation of metabotropic glutamate receptor 5. [PDF]
Clinical Science, 2018 Metabotropic glutamate receptors belong to class C G-protein-coupled receptors and consist of eight subtypes that are ubiquitously expressed throughout the central nervous system. In recent years, the metabotropic glutamate receptor subtype 5 (mGlu5) has
Phuc N. H. Trinh +3 more
semanticscholar +3 more sources
Journal of Biological Chemistry, 2014 Background: Amyloid-β oligomers trigger Alzheimer disease pathophysiology via the interaction of cellular prion protein (PrPC) with metabotropic glutamate receptor 5 (mGluR5).
Laura T. Haas +2 more
openalex +2 more sources
The role of the metabotropic glutamate receptor 5 in nicotine addiction [PDF]
CNS Spectrums, 2020 AbstractThis review summarizes the evidence for the potential involvement of metabotropic glutamate receptor 5 (mGluR5) in the development of nicotine addiction. Nicotine is consumed worldwide and is highly addictive. Previous research has extensively investigated the role of dopamine in association with reward learning and addiction, which has ...
Sylvia Terbeck +7 more
openaire +3 more sources