Operant sensation seeking requires metabotropic glutamate receptor 5 (mGluR5). [PDF]
PLoS ONE, 2010 Pharmacological and genetic studies have suggested that the metabotropic glutamate receptor 5 (mGluR5) is critically involved in mediating the reinforcing effects of drugs of abuse, but not food. The purpose of this study was to use mGluR5 knockout (KO),
Christopher M Olsen +3 more
doaj +5 more sources
Metabotropic glutamate receptor 5 (mGluR5) regulates bladder nociception [PDF]
Molecular Pain, 2012 Background Interstitial cystitis/painful bladder syndrome (IC/PBS), is a severely debilitating chronic condition that is frequently unresponsive to conventional pain medications.
Crock Lara W +8 more
doaj +3 more sources
Metabotropic glutamate receptor 5: a target for migraine therapy [PDF]
Annals of Clinical and Translational Neurology, 2016 Introduction Many patients suffering from migraine gain little relief from existing treatments partly because many existing acute and preventive therapies used in migraine have been adopted from other neurologic conditions such as depression or epilepsy.
Maggie W. Waung +4 more
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Metabotropic Glutamate Receptor Subtype 5 in Alcohol-Induced Negative Affect [PDF]
Brain Sciences, 2019 Allosteric modulators of metabotropic glutamate 5 receptors (mGlu5 receptors) have been identified as a promising treatment to independently alleviate both negative affective states and ethanol-seeking and intake.
Chelsea R. Kasten +2 more
doaj +3 more sources
Metabotropic glutamate receptor 5 may be involved in macrophage plasticity [PDF]
Biological Research, 2017 Background Macrophages are a functionally heterogeneous cell population and depending on microenvironments they polarize in two main groups: M1 and M2. Glutamic acid and glutamate receptors may participate in the regulation of macrophage plasticity.
Lali Shanshiashvili +4 more
doaj +3 more sources
Metabotropic glutamate receptor 5 (mGluR5) regulates white adipocyte browning [PDF]
Jichu yixue yu linchuang, 2021 Objective To investigate whether mGluR5 could regulate white adipocytes browning. Methods Western blot was used to test the expression of mGluR5 in white and brown adipose tissue. Lipid droplets morphology was microscoped after BODIPY staining.
LUO Xie, ZENG Li, YUAN Lei
doaj +1 more source
Examining sex differences in responses to footshock stress and the role of the metabotropic glutamate receptor 5: an [<sup>18</sup>F]FPEB and positron emission tomography study in rats. [PDF]
Neuropsychopharmacology, 2023 Asch RH +8 more
europepmc +3 more sources
Metabotropic glutamate receptor 5 in bulimia nervosa. [PDF]
Sci Rep, 2020 AbstractBulimia nervosa (BN) shares central features with substance-related and addictive disorders. The metabotropic glutamate receptor subtype 5 (mGlu5) plays an important role in addiction. Based on similarities between binge eating and substance-related and addictive disorders, we investigated mGlu5 in vivo in 15 female subjects with BN and 15 ...
Mihov Y +7 more
europepmc +7 more sources
Metabotropic glutamate receptor 5 neuroimaging in schizophrenia [PDF]
Schizophrenia Research, 2017 The metabotropic glutamate receptor 5 (mGluR5) is a promising drug target for the treatment of schizophrenia. In this study, we compared mGluR5 distribution volume ration (DVR) in subjects with schizophrenia and healthy controls. Given our previous findings, we matched samples for gender, age, and smoking status.
Akkus, Funda +5 more
openaire +2 more sources
Allosteric activation of metabotropic glutamate receptor 5 [PDF]
Journal of Biomolecular Structure and Dynamics, 2019 Metabotropic glutamate receptor 5 (mGluR5) is a class C G protein-coupled receptor (GPCR) with both an extracellular ligand binding site and an allosteric intrahelical chamber located similarly to the orthosteric ligand binding site of Class A GPCRs. Ligands binding to this ancestral site of mGluR5 can act as positive (PAM), negative (NAM) or silent ...
Balázs Jójárt +5 more
openaire +3 more sources