Operant sensation seeking requires metabotropic glutamate receptor 5 (mGluR5). [PDF]
PLoS ONE, 2010 Pharmacological and genetic studies have suggested that the metabotropic glutamate receptor 5 (mGluR5) is critically involved in mediating the reinforcing effects of drugs of abuse, but not food. The purpose of this study was to use mGluR5 knockout (KO),
Christopher M Olsen +3 more
doaj +6 more sources
Case Report: Guillain-Barré Syndrome Characterized by Severe Headache Associated With Metabotropic Glutamate Receptor 5 Antibody [PDF]
Frontiers in Immunology, 2022 Autoantibodies to metabotropic glutamate receptor 5 (mGluR5) are known to be the cause of autoimmune encephalitis, particularly limbic encephalitis, closely related to Hodgkin’s lymphoma (HL).
Weiqian Yan +4 more
doaj +2 more sources
Metabotropic glutamate receptor 5: a target for migraine therapy [PDF]
Annals of Clinical and Translational Neurology, 2016 Many patients suffering from migraine gain little relief from existing treatments partly because many existing acute and preventive therapies used in migraine have been adopted from other neurologic conditions such as depression or epilepsy.
Maggie W. Waung +4 more
semanticscholar +4 more sources
Metabotropic Glutamate Receptor Subtype 5 in Alcohol-Induced Negative Affect [PDF]
Brain Sciences, 2019 Allosteric modulators of metabotropic glutamate 5 receptors (mGlu5 receptors) have been identified as a promising treatment to independently alleviate both negative affective states and ethanol-seeking and intake.
Chelsea R. Kasten +2 more
doaj +4 more sources
Apo-state structure of the metabotropic glutamate receptor 5 transmembrane domain obtained using a photoswitchable ligand. [PDF]
Protein SciAbstract Metabotropic glutamate receptor 5 (mGlu5) is implicated in various neurodegenerative disorders, making it an attractive drug target. Although several ligand‐bound crystal structures of mGlu5 exist, their apo‐state crystal structure remains unknown.
Kondo Y +15 more
europepmc +2 more sources
Sequences within the C Terminus of the Metabotropic Glutamate Receptor 5 (mGluR5) Are Responsible for Inner Nuclear Membrane Localization* [PDF]
Journal of Biological Chemistry, 2017 Traditionally, G-protein-coupled receptors (GPCR) are thought to be located on the cell surface where they transmit extracellular signals to the cytoplasm.
Ismail Sergin +4 more
semanticscholar +3 more sources
The metabotropic glutamate 5 receptor modulates extinction and reinstatement of methamphetamine-seeking in mice. [PDF]
PLoS ONE, 2013 Methamphetamine (METH) is a highly addictive psychostimulant with no therapeutics registered to assist addicts in discontinuing use. Glutamatergic dysfunction has been implicated in the development and maintenance of addiction.
Rose Chesworth +3 more
doaj +3 more sources
Frontiers in Neuroscience, 2015 In the present review, we deliver an overview of the involvement of metabotropic glutamate receptor 5 (mGluR5) activity and density in pathological anxiety, mood disorders and addiction.
Sylvia eTerbeck +3 more
doaj +2 more sources
Metabotropic glutamate receptor 5 knockout rescues obesity phenotype in a mouse model of Huntington’s disease [PDF]
Scientific Reports, 2022 Obesity represents a global health problem and is characterized by metabolic dysfunctions and a low-grade chronic inflammatory state, which can increase the risk of comorbidities, such as atherosclerosis, diabetes and insulin resistance.
Rebeca P. M. Santos +12 more
doaj +2 more sources
Lower Limbic Metabotropic Glutamate Receptor 5 Availability in Alcohol Dependence [PDF]
Journal of Nuclear Medicine, 2018 Animal studies suggest an important role for the metabotropic glutamate receptor subtype 5 (mGlu5) in the pathophysiology of alcohol dependence, but direct human evidence is lacking. The goal of this study was to investigate cerebral mGlu5 availability in alcohol-dependent subjects versus controls using 18F-3-fluoro-5-[(pyridin-3-yl)ethynyl ...
G. Leurquin-Sterk +9 more
semanticscholar +6 more sources