Metabotropic Glutamate Receptor 5 Upregulation in A-Fibers after Spinal Nerve Injury: 2-Methyl-6-(Phenylethynyl)-Pyridine (MPEP) Reverses the Induced Thermal Hyperalgesia [PDF]
, 2002 Lindsey Hudson +6 more
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Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 1, July 2025.ABSTRACT The set‐up and progression of dyskinesia induced by 3,4‐dihydroxyphenylalanine (L‐DOPA) are strongly linked to oxidative stress and neuroinflammation. The aim of this work was to study and characterize the effects of the hydroalcoholic extract of Brazilian red propolis (HERP) on L‐DOPA–induced dyskinesia (LID) in hemiparkinsonian rats injected
Sheilla da Silva Barroso +9 more
wiley +1 more source
Distinct Functional Roles of the Metabotropic Glutamate Receptors 1 and 5 in the Rat Globus Pallidus [PDF]
, 2003 Olga V. Poisik +4 more
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Pharmacology Research &Perspectives, Volume 13, Issue 3, June 2025.ABSTRACT Multiple muscarinic M4 receptor modulators are currently advancing in clinical development for the treatment of positive symptoms in schizophrenia, including agonists and positive allosteric modulators. Considering the importance of comprehending M4 receptor pharmacology for these therapeutic applications, this study investigates M4 receptor ...
Madeleine Merz +5 more
wiley +1 more source
Proteomic analysis of native metabotropic glutamate receptor 5 protein complexes reveals novel molecular constituents [PDF]
, 2004 Carol D. Farr +7 more
openalex +1 more source
Sustainable Food Proteins, Volume 3, Issue 2, June 2025.This comprehensive review highlights the role of taste‐active peptides (TAPs) in modulating food taste and promoting health. It explores the taste profile, structure, sources, interactions with taste receptors, bioactivity, and potential applications of TAPs within the food and nutraceutical industries.
Nesma Elhadad, Jianping Wu
wiley +1 more source
Drug-Induced Plasticity Contributing to Heightened Relapse Susceptibility: Neurochemical Changes and Augmented Reinstatement in High-Intake Rats [PDF]
, 2010 A key in understanding the neurobiology of addiction and developing effective pharmacotherapies is revealing drug-induced plasticity that results in heightened relapse susceptibility.
Baker, David A. +5 more
core +1 more source
Interactions between Metabotropic Glutamate 5 and Adenosine A2AReceptors in Normal and Parkinsonian Mice [PDF]
, 2005 Anil Kachroo +5 more
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SorCS2 Is Important for Astrocytic Function in Neurovascular Signaling
Acta Physiologica, Volume 241, Issue 6, June 2025.ABSTRACT Introduction The receptor SorCS2 is involved in the trafficking of membrane receptors and transporters. It has been implicated in brain disorders and has previously been reported to be indispensable for ionotropic glutamatergic neurotransmission in the hippocampus.
Christian Staehr +14 more
wiley +1 more source
Hippocampal‐Specific Insulin Resistance Elicits Synaptic Effects on Glutamate Neurotransmission
Journal of Neurochemistry, Volume 169, Issue 6, June 2025.In animals with hippocampal‐specific insulin resistance, reduced vGluT2 and synaptophysin expression resulted in lowered synaptic glutamate concentrations. These animals also exhibited reduced serine phosphorylation of GluA1 (green postsynaptic receptor) and reduced expression of GluN2B (purple postsynaptic receptor).
Jennifer M. Erichsen +5 more
wiley +1 more source