Chronic cocaine enhances release of neuroprotective amino acid taurine: a microdialysis study [PDF]
Cocaine inhibits high-affinity neurotransmitter uptake at the presynaptic nerve terminals to increase synaptic levels of dopamine, norepinephrine and serotonin^1^. This increase of synaptic dopamine may cause neurotoxicity^2,3^.
Eitan Freedman+5 more
core +1 more source
Modulatory effects mediated by metabotropic glutamate receptor 5 on lateral geniculate nucleus relay cells [PDF]
Carmen de Labra+2 more
openalex +1 more source
Neural Metabolic Networks: Key Elements of Healthy Brain Function
This review originated from the Fourth International Society for Neurochemistry (ISN) and Journal of Neurochemistry (JNC) Flagship School (2022). Here, we describe how the specific bioenergetic profiles and metabolic exchanges between brain cells enable and gate synaptic function and behavior. Then, based on this analysis, we discuss the potential role
Nimrod Madrer+20 more
wiley +1 more source
Case report: Orthostatic leg tremor as the initial manifestation in a patient with metabotropic glutamate receptor-5 encephalitis without cortical dysfunction: complexities in identification and treatment. [PDF]
Yang X+6 more
europepmc +1 more source
The Scaffold Protein Homer1b/c Links Metabotropic Glutamate Receptor 5 to Extracellular Signal-Regulated Protein Kinase Cascades in Neurons [PDF]
Limin Mao+5 more
openalex +1 more source
Autism spectrum disorder (ASD) is a neurodevelopmental condition linked to glutamatergic neurotransmission abnormalities. We analyzed by HPLC the cerebral and peripheral profiles of D‐aspartate, D‐serine, and other L‐amino acids involved in NMDA receptor signaling in environmental ASD rat models prenatally exposed to lipopolysaccharide or valproate ...
Anna Di Maio+9 more
wiley +1 more source
Homer 1a uncouples metabotropic glutamate receptor 5 from postsynaptic effectors [PDF]
Paul J. Kammermeier, Paul F. Worley
openalex +1 more source
Abstract The sex hormones progesterone (P) and oestrogen (E) reorganize GABAergic transmission in the prefrontal cortex (PFC) during the transition from childhood to adolescence, generating a new excitatory–inhibitory balance necessary for the computational capacity of the mature PFC.
Aitana Vázquez‐Sola+2 more
wiley +1 more source
Repeated \u3cem\u3eN\u3c/em\u3e-Acetylcysteine Administration Alters Plasticity-Dependent Effects of Cocaine [PDF]
Cocaine produces a persistent reduction in cystine–glutamate exchange via system xc− in the nucleus accumbens that may contribute to pathological glutamate signaling linked to addiction.
Abdulhameed, Omer+7 more
core +1 more source
Differences in Quantification of the Metabotropic Glutamate Receptor 5 Across Bipolar Disorder and Major Depressive Disorder. [PDF]
Holmes SE+11 more
europepmc +1 more source