Metabotropic glutamate receptor 5 neuroimaging in schizophrenia [PDF]
Schizophrenia Research, 2017 The metabotropic glutamate receptor 5 (mGluR5) is a promising drug target for the treatment of schizophrenia. In this study, we compared mGluR5 distribution volume ration (DVR) in subjects with schizophrenia and healthy controls. Given our previous findings, we matched samples for gender, age, and smoking status.
F. Akkus +5 more
semanticscholar +4 more sources
Glutamate Delta-1 Receptor Regulates Metabotropic Glutamate Receptor 5 Signaling in the Hippocampus [PDF]
Molecular Pharmacology, 2016 The delta family of ionotropic glutamate receptors consists of glutamate delta-1 (GluD1) and glutamate delta-2 receptors. We have previously shown that GluD1 knockout mice exhibit features of developmental delay, including impaired spine pruning and switch in the N-methyl-D-aspartate receptor subunit, which are relevant to autism and other ...
P. Suryavanshi +5 more
semanticscholar +4 more sources
Metabotropic Glutamate Receptor 5 and Glutamate Involvement in Major Depressive Disorder: A Multimodal Imaging Study [PDF]
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2017 Chadi G. Abdallah +15 more
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Metabotropic glutamate receptor 5 (mGluR5) regulates white adipocyte browning [PDF]
Jichu yixue yu linchuang, 2021 Objective To investigate whether mGluR5 could regulate white adipocytes browning. Methods Western blot was used to test the expression of mGluR5 in white and brown adipose tissue. Lipid droplets morphology was microscoped after BODIPY staining.
LUO Xie, ZENG Li, YUAN Lei
doaj
Association of genetic variants of Glutamate Metabotropic Receptor 5 gene and state-anhedonia
European Psychiatry, 2022 Introduction Andedonia is one of the core symptoms of depression. It is known that in case of depressed individuals experiencing anhedonia, the classical antidepressants are often ineffective, thus investigation of this symptom would be essential ...
D. Török +6 more
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Antibodies to metabotropic glutamate receptor 5 in the Ophelia syndrome [PDF]
Neurology, 2011 To report the metabotropic glutamate receptor 5 (mGluR5) as the autoantigen of antibodies from 2 patients with Hodgkin lymphoma (HL) and limbic encephalopathy (Ophelia syndrome).Immunohistochemistry with brain tissue and cultures of rat hippocampal neurons were used to demonstrate antibodies. Immunoprecipitation, mass spectrometry, and mGluR5-null mice
Jean-Christophe Antoine +15 more
openaire +4 more sources
Repurposing Fragile X Drugs to Inhibit SARS-CoV-2 Viral Reproduction
Frontiers in Cell and Developmental Biology, 2020 The COVID-19 pandemic is a global health crisis that requires the application of interdisciplinary research to address numerous knowledge gaps including molecular strategies to prevent viral reproduction in affected individuals.
Cara J. Westmark +6 more
doaj +1 more source
Erratum to: Metabotropic glutamate receptor 5 may be involved in macrophage plasticity [PDF]
Biological Research, 2017 Lali Shanshiashvili +4 more
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Metabotropic Glutamate Receptor 5 Is a Disulfide-linked Dimer [PDF]
Journal of Biological Chemistry, 1996 The sequences of the metabotropic glutamate receptors (mGluRs) show little homology with other members of the G protein-coupled receptor family and exhibit several distinctive features, including a large N-terminal extracellular domain with 17 cysteines in conserved positions.
Carmelo Romano +2 more
openaire +3 more sources
The Role of Glutamate Receptors in Epilepsy
Biomedicines, 2023 Glutamate is an essential excitatory neurotransmitter in the central nervous system, playing an indispensable role in neuronal development and memory formation. The dysregulation of glutamate receptors and the glutamatergic system is involved in numerous
Tsang-Shan Chen +3 more
doaj +1 more source