Encephalitis Associated to Metabotropic Glutamate Receptor 5 (mGluR5) Antibodies in Cerebrospinal Fluid [PDF]
Frontiers in Immunology, 2018 A 68-years-old Hispanic man, complained of night sweats, low grade fewer, unexplained weight loss, and memory problems over 3 months. Abdominal tomography showed multiple intra-abdominal adenopathy and biopsy confirmed classic Hodgkin's lymphoma.
Carlos Guevara +10 more
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Biased agonism and allosteric modulation of metabotropic glutamate receptor 5. [PDF]
Clinical Science, 2018 Metabotropic glutamate receptors belong to class C G-protein-coupled receptors and consist of eight subtypes that are ubiquitously expressed throughout the central nervous system. In recent years, the metabotropic glutamate receptor subtype 5 (mGlu5) has
Phuc N. H. Trinh +3 more
semanticscholar +3 more sources
Metabotropic glutamate receptor 5 inhibits α-synuclein-induced microglia inflammation to protect from neurotoxicity in Parkinson’s disease [PDF]
Journal of Neuroinflammation, 2021 Background Microglia activation induced by α-synuclein (α-syn) is one of the most important factors in Parkinson’s disease (PD) pathogenesis. However, the molecular mechanisms by which α-syn exerts neuroinflammation and neurotoxicity remain largely ...
Ya-Nan Zhang +5 more
doaj +2 more sources
Journal of Biological Chemistry, 2014 Background: Amyloid-β oligomers trigger Alzheimer disease pathophysiology via the interaction of cellular prion protein (PrPC) with metabotropic glutamate receptor 5 (mGluR5).
Laura T. Haas +2 more
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Erratum to: Metabotropic glutamate receptor 5 may be involved in macrophage plasticity [PDF]
Biological Research, 2017 Lali Shanshiashvili +4 more
doaj +4 more sources
The role of the metabotropic glutamate receptor 5 in nicotine addiction [PDF]
CNS Spectrums, 2020 AbstractThis review summarizes the evidence for the potential involvement of metabotropic glutamate receptor 5 (mGluR5) in the development of nicotine addiction. Nicotine is consumed worldwide and is highly addictive. Previous research has extensively investigated the role of dopamine in association with reward learning and addiction, which has ...
Sylvia Terbeck +7 more
openaire +3 more sources
Metabotropic Glutamate Receptor 5 and Glutamate Involvement in Major Depressive Disorder: A Multimodal Imaging Study [PDF]
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2017 Chadi G. Abdallah +15 more
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Metabotropic glutamate receptor 5 (mGluR5) regulates white adipocyte browning [PDF]
Jichu yixue yu linchuang, 2021 Objective To investigate whether mGluR5 could regulate white adipocytes browning. Methods Western blot was used to test the expression of mGluR5 in white and brown adipose tissue. Lipid droplets morphology was microscoped after BODIPY staining.
LUO Xie, ZENG Li, YUAN Lei
doaj
Association of genetic variants of Glutamate Metabotropic Receptor 5 gene and state-anhedonia
European Psychiatry, 2022 Introduction Andedonia is one of the core symptoms of depression. It is known that in case of depressed individuals experiencing anhedonia, the classical antidepressants are often ineffective, thus investigation of this symptom would be essential ...
D. Török +6 more
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Antibodies to metabotropic glutamate receptor 5 in the Ophelia syndrome [PDF]
Neurology, 2011 To report the metabotropic glutamate receptor 5 (mGluR5) as the autoantigen of antibodies from 2 patients with Hodgkin lymphoma (HL) and limbic encephalopathy (Ophelia syndrome).Immunohistochemistry with brain tissue and cultures of rat hippocampal neurons were used to demonstrate antibodies. Immunoprecipitation, mass spectrometry, and mGluR5-null mice
Jean-Christophe Antoine +15 more
openaire +4 more sources