Results 21 to 30 of about 455,046 (297)

Cerebral expression of metabotropic glutamate receptor subtype 5 in idiopathic autism spectrum disorder and fragile X syndrome: A pilot study [PDF]

, 2021
Multiple lines of evidence suggest that dysfunction of the metabotropic glutamate receptor subtype 5 ...
Barret, Olivier, Brašić, James Robert, Budimirovic, Dejan B, Jennings, Danna, Martin, Samuel D, Nandi, Ayon, Russell, David S, Sedlak, Thomas, Seibyl, John P, Slifer, Keith, Wong, Dean F   +10 more
core   +3 more sources

Fragile X Mental Retardation Protein and cerebral expression of metabotropic glutamate receptor subtype 5 in men with fragile X syndrome: A pilot study [PDF]

, 2021
Multiple lines of evidence suggest that a deficiency of Fragile X Mental Retardation Protein (FMRP) mediates dysfunction of the metabotropic glutamate receptor subtype 5 ...
Barret, Olivier, Berry-Kravis, Elizabeth M, Brašić, James Robert, Budimirovic, Dejan B, Goodman, Jack Alexander, Jennings, Danna, Martin, Samuel D, Mathur, Anil Kumar, Nandi, Ayon, Russell, David S, Sedlak, Thomas, Seibyl, John P, Slifer, Keith, Wong, Dean F   +13 more
core   +3 more sources

Metabotropic glutamate receptor 5: a target for migraine therapy [PDF]

Annals of Clinical and Translational Neurology, 2016
AbstractIntroductionMany patients suffering from migraine gain little relief from existing treatments partly because many existing acute and preventive therapies used in migraine have been adopted from other neurologic conditions such as depression or epilepsy.
Maggie W. Waung, Simon Akerman, Charlotte Keywood, Peter J. Goadsby, Peter J. Goadsby, Mark Wakefield   +5 more
openaire   +3 more sources

Metabotropic glutamate receptor 5 (mGluR5) regulates white adipocyte browning [PDF]

Jichu yixue yu linchuang, 2021
Objective To investigate whether mGluR5 could regulate white adipocytes browning. Methods Western blot was used to test the expression of mGluR5 in white and brown adipose tissue. Lipid droplets morphology was microscoped after BODIPY staining.
LUO Xie, ZENG Li, YUAN Lei
doaj  

Association of genetic variants of Glutamate Metabotropic Receptor 5 gene and state-anhedonia

European Psychiatry, 2022
Introduction Andedonia is one of the core symptoms of depression. It is known that in case of depressed individuals experiencing anhedonia, the classical antidepressants are often ineffective, thus investigation of this symptom would be essential ...
D. Török, X. Gonda, Z. Gal, N. Eszlari, G. Bagdy, G. Juhasz, P. Petschner   +6 more
doaj   +1 more source

Antibodies to metabotropic glutamate receptor 5 in the Ophelia syndrome [PDF]

Neurology, 2011
To report the metabotropic glutamate receptor 5 (mGluR5) as the autoantigen of antibodies from 2 patients with Hodgkin lymphoma (HL) and limbic encephalopathy (Ophelia syndrome).Immunohistochemistry with brain tissue and cultures of rat hippocampal neurons were used to demonstrate antibodies. Immunoprecipitation, mass spectrometry, and mGluR5-null mice
Jean-Christophe Antoine, Eugenia Martinez-Hernandez, Anis Contractor, Cornelia Kornblum, Eric Lancaster, Jian Xu, S. Weaver, Josep Dalmau, Josep Dalmau, Stephen Wong, Rita J. Balice-Gordon, Jérôme Honnorat, Maarten J. Titulaer, M. Boulos, E. Liebers, Christian G. Bien   +15 more
openaire   +4 more sources

MicroRNA binding site variation is enriched in psychiatric disorders

Human Mutation, Volume 43, Issue 12, Page 2153-2169, December 2022., 2022
Abstract Psychiatric disorders have a polygenic architecture, often associated with dozens or hundreds of independent genomic loci. Most associated loci impact noncoding regions of the genome, suggesting that the majority of disease heritability originates from the disruption of regulatory sequences.
Michael P. Geaghan, William R. Reay, Murray J. Cairns   +2 more
wiley   +1 more source

Repurposing Fragile X Drugs to Inhibit SARS-CoV-2 Viral Reproduction

Frontiers in Cell and Developmental Biology, 2020
The COVID-19 pandemic is a global health crisis that requires the application of interdisciplinary research to address numerous knowledge gaps including molecular strategies to prevent viral reproduction in affected individuals.
Cara J. Westmark, Maki Kiso, Peter Halfmann, Pamela R. Westmark, Yoshihiro Kawaoka, Yoshihiro Kawaoka, Yoshihiro Kawaoka   +6 more
doaj   +1 more source

Accuracy in readout of glutamate concentrations by neuronal cells [PDF]

The European Physical Journal E, 46(4), 30 (2023), 2023
Glutamate and glycine are important neurotransmitters in the brain. An action potential prop- agating in the terminal of a presynatic neuron causes the release of glutamate and glycine in the synapse by vesicles fusing with the cell membrane, which then activate various receptors on the cell membrane of the post synaptic neuron.
arxiv   +1 more source

Metabotropic Glutamate Receptor 5 Is a Disulfide-linked Dimer [PDF]

Journal of Biological Chemistry, 1996
The sequences of the metabotropic glutamate receptors (mGluRs) show little homology with other members of the G protein-coupled receptor family and exhibit several distinctive features, including a large N-terminal extracellular domain with 17 cysteines in conserved positions.
Carmelo Romano, Karen L. O'Malley, Wan Lin Yang   +2 more
openaire   +3 more sources