Results 31 to 40 of about 455,046 (297)
The Role of Glutamate Receptors in Epilepsy
Biomedicines, 2023 Glutamate is an essential excitatory neurotransmitter in the central nervous system, playing an indispensable role in neuronal development and memory formation. The dysregulation of glutamate receptors and the glutamatergic system is involved in numerous
Tsang-Shan Chen +3 more
doaj +1 more source
Brain Pathology, Volume 33, Issue 1, January 2023., 2023 Differential alteration of synaptic versus extrasynaptic NMDARs in P301S mice. Reduced density of synaptic NMDARs in excitatory synapses in the hippocampus of P301S mice at 10 months. NMDARs at excitatory synapses established on pyramidal cell spines and interneurons are significantly reduced in the CA1 region of the hippocampus compared to age‐matched
Rocío Alfaro‐Ruiz +8 more
wiley +1 more source
Kainate receptor modulation by NETO2 [PDF]
Nature, 599(7884), 325-329 (2021), 2023 Glutamate-gated kainate receptors (KARs) are ubiquitous in the central nervous system of vertebrates, mediate synaptic transmission on post-synapse, and modulate transmitter release on pre-synapse. In the brain, the trafficking, gating kinetics, and pharmacology of KARs are tightly regulated by Neuropilin and tolloid-like proteins (Netos).
arxiv +1 more source
The fate of interneurons, GABAA receptor sub‐types and perineuronal nets in Alzheimer's disease
Brain Pathology, Volume 33, Issue 1, January 2023., 2023 Abstract Alzheimer's disease (AD) is the most common neurological disease, which is associated with gradual memory loss and correlated with synaptic hyperactivity and abnormal oscillatory rhythmic brain activity that precedes phenotypic alterations and is partly responsible for the spread of the disease pathology.
Afia B. Ali +2 more
wiley +1 more source
Emotional Impairment and Persistent Upregulation of mGlu5 Receptor following Morphine Abstinence: Implications of an mGlu5-MOPr Interaction. [PDF]
, 2016 BACKGROUND: A difficult problem in treating opioid addicts is the maintenance of a drug-free state because of the negative emotional symptoms associated with withdrawal, which may trigger relapse.
Bailey, A +8 more
core +1 more source
British Journal of Pharmacology, EarlyView., 2023 Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi +6 more
wiley +1 more source
Group I metabotropic glutamate receptors are expressed in the chicken retina and by cultured retinal amacrine cells [PDF]
, 2001 Glutamate is well established as an excitatory neurotransmitter in the vertebrate retina. Its role as a modulator of retinal function, however, is poorly understood.
Gleason, Evanna L. +3 more
core +2 more sources
Gαq signalling from endosomes: A new conundrum
British Journal of Pharmacology, EarlyView., 2023 Abstract G‐protein‐coupled receptors (GPCRs) constitute the largest family of membrane receptors, and are involved in the transmission of a variety of extracellular stimuli such as hormones, neurotransmitters, light and odorants into intracellular responses.
Carole Daly, Bianca Plouffe
wiley +1 more source
Synergistic inhibition of survival, proliferation, and migration of U87 cells with a combination of LY341495 and Iressa. [PDF]
PLoS ONE, 2013 Glioblastomas exploit various molecular pathways to promote glutamate- dependent growth by activating the AMPA (2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl) propanoic acid) receptor, the group II metabotropic glutamate receptor, mGluR, and the epidermal ...
Zarina Yelskaya +5 more
doaj +1 more source
Glutamate Delta-1 Receptor Regulates Metabotropic Glutamate Receptor 5 Signaling in the Hippocampus [PDF]
Molecular Pharmacology, 2016 The delta family of ionotropic glutamate receptors consists of glutamate delta-1 (GluD1) and glutamate delta-2 receptors. We have previously shown that GluD1 knockout mice exhibit features of developmental delay, including impaired spine pruning and switch in the N-methyl-D-aspartate receptor subunit, which are relevant to autism and other ...
Subhash C. Gupta +5 more
openaire +3 more sources