Results 31 to 40 of about 51,164 (271)
Lower Limbic Metabotropic Glutamate Receptor 5 Availability in Alcohol Dependence [PDF]
Journal of Nuclear Medicine, 2018 Animal studies suggest an important role for the metabotropic glutamate receptor subtype 5 (mGlu5) in the pathophysiology of alcohol dependence, but direct human evidence is lacking. The goal of this study was to investigate cerebral mGlu5 availability in alcohol-dependent subjects versus controls using 18F-3-fluoro-5-[(pyridin-3-yl)ethynyl ...
G. Leurquin-Sterk +9 more
semanticscholar +6 more sources
Synergistic inhibition of survival, proliferation, and migration of U87 cells with a combination of LY341495 and Iressa. [PDF]
PLoS ONE, 2013 Glioblastomas exploit various molecular pathways to promote glutamate- dependent growth by activating the AMPA (2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl) propanoic acid) receptor, the group II metabotropic glutamate receptor, mGluR, and the epidermal ...
Zarina Yelskaya +5 more
doaj +1 more source
Metabotropic glutamate receptor 5 as a potential target for smoking cessation [PDF]
Psychopharmacology, 2016 Most habitual smokers find it difficult to quit smoking because they are dependent upon the nicotine present in tobacco smoke. Tobacco dependence is commonly treated pharmacologically using nicotine replacement therapy or drugs, such as varenicline, that target the nicotinic receptor.
CHIAMULERA, Cristiano +2 more
openaire +4 more sources
Neurobiology of Disease, 2014 Amyotrophic lateral sclerosis (ALS) is a late-onset fatal neurodegenerative disease reflecting degeneration of upper and lower motoneurons (MNs).
Marco Milanese +11 more
doaj +1 more source
Cells, 2023 Sleep is an essential innate but complex behaviour which is ubiquitous in the animal kingdom. Our knowledge of the distinct neural circuit mechanisms that regulate sleep and wake states in the brain are, however, still limited.
Richard Teke Ngomba +4 more
doaj +1 more source
Cerebellum & Ataxias, 2018 Autism is a neurodevelopmental disorder that is first manifested during early childhood. Postmortem experiments have identified significantly elevated expression of metabotropic glutamate receptor 5 (mGluR5) in cerebellar vermis and prefrontal cortex of ...
S. Fatemi +9 more
semanticscholar +1 more source
Effect of age on brain metabotropic glutamate receptor subtype 5 measured with [18F]FPEB PET
NeuroImage, 2021 Objective: Metabotropic glutamate receptor subtype 5 (mGluR5) is integral to the brain glutamatergic system and cognitive function. This study investigated whether aging is associated with decreased brain mGluR5 availability.
Adam P. Mecca +15 more
doaj +1 more source
Scientific Reports, 2018 Metabotropic glutamate receptor 5 (mGlu5) has been implicated in certain forms of synaptic plasticity and cognitive function. mGlu5 knockout (KO) mice and mGlu5 antagonists have been previously used to study the pathophysiology of schizophrenia as they ...
A. Zeleznikow-Johnston +5 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2022 The type 5 metabotropic glutamate receptor, mGlu5, has been proposed as a potential therapeutic target for the treatment of several neurodegenerative diseases.
Rebecca F. Budgett +5 more
doaj +1 more source
Scientific Reports, 2017 Patients with chronic pain easily accompany the negative mood symptoms such as depression and anxiety, and these disturbances in turn affect the aversive perception of pain. However, the underlying mechanisms are largely unknown. We hypothesized that the
Geehoon Chung +6 more
semanticscholar +1 more source