Results 41 to 50 of about 455,046 (297)

Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome [PDF]

, 2012
Fragile X syndrome, the most commonly known genetic cause of autism, is due to loss of the fragile X mental retardation protein, which regulates signal transduction at metabotropic glutamate receptor-5 in the brain.
DiPatrizio, Nicholas V., Frick, Andreas, Ginger, Melanie, Henstridge, Christopher M., Jung, Kwang-Mook, Katona, Istvan, Lassalle, Olivier, Mackie, Ken, Manzoni, Olivier J., Martin, Henry, Neuhofer, Daniela, Piomelli, Daniele, Sepers, Marja   +12 more
core   +5 more sources

Aquaporin 4-Mediated Glutamate-Induced Astrocyte Swelling Is Partially Mediated through Metabotropic Glutamate Receptor 5 Activation

Frontiers in Cellular Neuroscience, 2017
Astrocytes are one of the most abundant cell types in the mammalian central nervous system (CNS), and astrocyte swelling is the primary event associated with brain edema.
Fang Yuan, Fang Yuan, Fang Yuan, Fang Yuan, Fang Yuan, Zhongfang Shi, Zhongfang Shi, Zhongfang Shi, Zhongfang Shi, Zhongfang Shi, Wei Zhang, Wei Zhang, Wei Zhang, Wei Zhang, Wei Zhang, Yang Lu, Yang Lu, Yang Lu, Yang Lu, Yang Lu, Yi Lu, Yi Lu, Yi Lu, Yi Lu, Yi Lu, Lixin Xu, Lixin Xu, Lixin Xu, Lixin Xu, Lixin Xu, Qing Fang, Qing Fang, Qing Fang, Qing Fang, Qing Fang, Min Wu, Min Wu, Min Wu, Min Wu, Min Wu, Mei Jia, Mei Jia, Mei Jia, Mei Jia, Mei Jia, Yujiao Wang, Yujiao Wang, Yujiao Wang, Yujiao Wang, Yujiao Wang, Liping Dong, Liping Dong, Liping Dong, Liping Dong, Liping Dong, Xu Yan, Xu Yan, Xu Yan, Xu Yan, Xu Yan, Shaohua Yang, Shaohua Yang, Shaohua Yang, Shaohua Yang, Shaohua Yang, Shaohua Yang   +65 more
doaj   +1 more source

The Metabotropic Glutamate 5 Receptor in Sleep and Wakefulness: Focus on the Cortico-Thalamo-Cortical Oscillations

Cells, 2023
Sleep is an essential innate but complex behaviour which is ubiquitous in the animal kingdom. Our knowledge of the distinct neural circuit mechanisms that regulate sleep and wake states in the brain are, however, still limited.
Richard Teke Ngomba, Annika Lüttjohann, Aaron Dexter, Swagat Ray, Gilles van Luijtelaar   +4 more
doaj   +1 more source

Metabotropic glutamate receptor 5 as a potential target for smoking cessation [PDF]

Psychopharmacology, 2016
Most habitual smokers find it difficult to quit smoking because they are dependent upon the nicotine present in tobacco smoke. Tobacco dependence is commonly treated pharmacologically using nicotine replacement therapy or drugs, such as varenicline, that target the nicotinic receptor.
CHIAMULERA, Cristiano, MARZO, CLAUDIO MARCELLO, Balfour, David J. K.   +2 more
openaire   +4 more sources

G protein-coupled receptor signalling in astrocytes in health and disease: A focus on metabotropic glutamate receptors [PDF]

, 2012
Work published over the past 10–15 years has caused the neuroscience community to engage in a process of constant re-evaluation of the roles of glial cells in the mammalian central nervous system.
Bradley, Sophie J., Challiss, R.A. John
core   +1 more source

mGluR5 antagonism inhibits cocaine reinforcement and relapse by elevation of extracellular glutamate in the nucleus accumbens via a CB1 receptor mechanism. [PDF]

, 2018
Metabotropic glutamate receptor 5 (mGluR5) antagonism inhibits cocaine self-administration and reinstatement of drug-seeking behavior. However, the cellular and molecular mechanisms underlying this action are poorly understood.
Bi, Guo-Hua, Gardner, Eliot L, He, Yi, Jordan, Chloe J, Li, Jie, Li, Xia, Peng, Xiao-Qing, Xi, Zheng-Xiong, Yang, Hong-Ju, Zhang, Hai-Ying   +9 more
core   +2 more sources

Targeting the Type 5 Metabotropic Glutamate Receptor: A Potential Therapeutic Strategy for Neurodegenerative Diseases?

Frontiers in Pharmacology, 2022
The type 5 metabotropic glutamate receptor, mGlu5, has been proposed as a potential therapeutic target for the treatment of several neurodegenerative diseases.
Rebecca F. Budgett, Geor Bakker, Eugenia Sergeev, Kirstie A. Bennett, Sophie J. Bradley, Sophie J. Bradley   +5 more
doaj   +1 more source

Metabotropic glutamate receptor subtype 5 antagonism in learning and memory [PDF]

European Journal of Pharmacology, 2010
The role of the metabotropic glutamate receptor 5 (mGlu(5) receptor) in learning and memory and other behaviors are reviewed by examining the influence of selective antagonists and genetic knockout on performance. This receptor is involved in spatial learning, contextual fear conditioning, inhibitory avoidance, fear potentiated startle, and conditioned
Simonyi, Agnes, Schachtman, Todd R., Christoffersen, Gert Rene Juul   +2 more
openaire   +3 more sources

Mechanisms associated with activation of intracellular metabotropic glutamate receptor, mGluR5 [PDF]

, 2016
The group 1 metabotropic glutamate receptor, mGluR5, is found on the cell surface as well as on intracellular membranes where it can mediate both overlapping and unique signaling effects.
Jong, Yuh-Jiin I, O\u27Malley, Karen L
core   +2 more sources

mGlu1 Receptors Monopolize the Synaptic Control of Cerebellar Purkinje Cells by Epigenetically Down-Regulating mGlu5 Receptors [PDF]

, 2018
In cerebellar Purkinje cells (PCs) type-1 metabotropic glutamate (mGlu1) receptors play a key role in motor learning and drive the refinement of synaptic innervation during postnatal development.
Atsu Aiba, Cristina Zappulla, Ferdinando Nicoletti, Francesca Liberatore, Giada Mascio, Giorgio Carmignoto, Giuseppe Battaglia, Harumi Nakao, Marta Motolese, Masahiko Watanabe, Micaela Zonta, Michele Madonna, Milena Cannella, Pamela Scarselli, Roberto Gradini, Serena Notartomaso, Valeria Bruno   +16 more
core   +2 more sources