Results 51 to 60 of about 55,471 (274)
Neurobiology of Disease, 2018 Deleterious mutations in the glutamate receptor metabotropic 1 gene (GRM1) cause a recessive form of cerebellar ataxia, SCAR13. GRM1 and GRM5 code for the metabotropic glutamate type 1 (mGlu1) and type 5 (mGlu5) receptors, respectively.
Simone Bossi +11 more
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Cell Reports, 2023 Summary: Obesity-mediated hypoxic stress underlies inflammation, including interferon (IFN)-γ production by natural killer (NK) cells in white adipose tissue. However, the effects of obesity on NK cell IFN-γ production remain obscure.
Hee-Hoon Kim +19 more
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Journal of Pharmacological Sciences, 2008 The effect of [pGlu4,Cyt6,Arg8]-vasopressin fragment 4-9 (AVP4-9) on group I metabotropic glutamate (mGlu1) receptor antagonist–induced memory deficits was studied using 8-arm radial maze performance with 4 arms baited.
Tadatsugu Tarumi +3 more
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Pharmacological And Genetic Reversal Of Age-Dependent Cognitive Deficits Attributable To Decreased Presenilin Function [PDF]
, 2010 Alzheimer\u27s disease (AD) is the leading cause of cognitive loss and neurodegeneration in the developed world. Although its genetic and environmental causes are not generally known, familial forms of the disease (FAD) are attributable to mutations in a
Bell, A. J. +19 more
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The prion protein regulates glutamate-mediated Ca2+ entry and mitochondrial Ca2+ accumulation in neurons [PDF]
, 2017 The cellular prion protein (PrPC) whose conformational misfolding leads to the production of deadly prions, has a still-unclarified cellular function despite decades of intensive research.
Bertoli, Alessandro +8 more
core +1 more source
Metabotropic Glutamate Receptor Subtype 5 Antagonists MPEP and MTEP [PDF]
CNS Drug Reviews, 2006 ABSTRACTGlutamate regulates the function of central nervous system (CNS), in part, through the cAMP and/or IP3/DAG second messenger‐associated metabotropic glutamate receptors (mGluRs). The mGluR5 antagonist 2‐methyl‐6‐(phenylethynyl)‐pyridine (MPEP) has been extensively used to elucidate potential physiological and pathophysiological functions of ...
Paul M, Lea, Alan I, Faden
openaire +2 more sources
Loss of Metabotropic Glutamate Receptor 5 Function on Peripheral Benzodiazepine Receptor in Mice Prenatally Exposed to LPS. [PDF]
PLoS ONE, 2015 Parental microglial induced neuroinflammation, triggered by bacterial- or viral infections, can induce neuropsychiatric disorders like schizophrenia and autism to offspring in animal models.
Dany Arsenault +7 more
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Frontiers in Neurology, 2022 Abnormalities in the expression of metabotropic glutamate receptor type 5 (mGluR5) have been observed in the hippocampus of patients with drug-resistant mesial Temporal Lobe Epilepsy (mTLE).
Maria Zimmermann +14 more
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Ophelia syndrome with metabotropic glutamate receptor 5 antibodies in CSF [PDF]
Neurology, 2013 A 35-year-old man developed progressive memory problems and personality changes over the course of 6 months. This amnesia culminated in overt functional impairment as he began getting lost in familiar places and paid his rent multiple times in one day. He then displayed increased aggression and was admitted to hospital after assaulting a family member.
Arimin, Mat +6 more
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Frontiers in Neuroscience, 2015 In the present review, we deliver an overview of the involvement of metabotropic glutamate receptor 5 (mGluR5) activity and density in pathological anxiety, mood disorders and addiction.
Sylvia eTerbeck +3 more
doaj +1 more source