Results 51 to 60 of about 51,164 (271)

Mice Lacking Metabotropic Glutamate Receptor 5 Show Impaired Learning and Reduced CA1 Long-Term Potentiation (LTP) But Normal CA3 LTP

Journal of Neuroscience, 1997
Class I metabotropic glutamate receptors (mGluRs) have been postulated to play a role in synaptic plasticity. To test the involvement of one member of this class, we have recently generated mutant mice that express no mGluR5 but normal levels of other ...
Y. Lu, Zhengping Jia, C. Janus, J. Henderson, R. Gerlai, J. Wojtowicz, J. Roder, Samuel Lunenfeld Re   +7 more
semanticscholar   +1 more source

Metabotropic glutamate 5 receptors regulate sensitivity to ethanol in mice [PDF]

The International Journal of Neuropsychopharmacology, 2008
The metabotropic glutamate receptor 5 (mGlu5) has been implicated in ethanol- and drug-seeking behaviours in rodent studies. Here we examine a number of ethanol-related behavioural assays in mice lacking mGlu5 and wild-type littermates. In a two-bottle free-choice paradigm, mGlu5-deficient mice consumed less ethanol with a reduced preference compared ...
Elvan Djouma, Elvan Djouma, Jeppe Kirchhoff, Michael K. Bird, Andrew J Lawrence   +4 more
openaire   +3 more sources

Loss of Metabotropic Glutamate Receptor 5 Function on Peripheral Benzodiazepine Receptor in Mice Prenatally Exposed to LPS. [PDF]

PLoS ONE, 2015
Parental microglial induced neuroinflammation, triggered by bacterial- or viral infections, can induce neuropsychiatric disorders like schizophrenia and autism to offspring in animal models.
Dany Arsenault, Katherine Coulombe, Aijun Zhu, Chunyu Gong, Kun-Eek Kil, Ji-Kyung Choi, Pekka Poutiainen, Anna-Liisa Brownell   +7 more
doaj   +1 more source

Reduced Metabotropic Glutamate Receptor Type 5 Availability in the Epileptogenic Hippocampus: An in vitro Study

Frontiers in Neurology, 2022
Abnormalities in the expression of metabotropic glutamate receptor type 5 (mGluR5) have been observed in the hippocampus of patients with drug-resistant mesial Temporal Lobe Epilepsy (mTLE).
Maria Zimmermann, Maria Zimmermann, Luciano Minuzzi, Luciano Minuzzi, Arturo Aliaga Aliaga, Arturo Aliaga Aliaga, Marie-Christine Guiot, Jeffery A. Hall, Jean-Paul Soucy, Jean-Paul Soucy, Gassan Massarweh, Salah El Mestikawy, Pedro Rosa-Neto, Pedro Rosa-Neto, Eliane Kobayashi   +14 more
doaj   +1 more source

Sequences within the C Terminus of the Metabotropic Glutamate Receptor 5 (mGluR5) Are Responsible for Inner Nuclear Membrane Localization*

Journal of Biological Chemistry, 2017
Traditionally, G-protein-coupled receptors (GPCR) are thought to be located on the cell surface where they transmit extracellular signals to the cytoplasm.
Ismail Sergin, Y. Jong, S. Harmon, Vikas Kumar, K. O’Malley   +4 more
semanticscholar   +1 more source

Autoimmune encephalitis with mGluR5 antibodies: A case series from China and review of the literature

Frontiers in Immunology, 2023
BackgroundOnly 15 patients of autoimmune encephalitis with metabotropic glutamate receptor 5 (mGluR5) antibodies have been reported worldwide since 2011, mostly from western countries.
Kundian Guo, Kundian Guo, Xu Liu, Xu Liu, Xue Gong, Xue Gong, Aiqing Li, Aiqing Li, Yue Liu, Yue Liu, Xingjie Li, Xingjie Li, Dong Zhou, Dong Zhou, Zhen Hong, Zhen Hong, Zhen Hong   +16 more
doaj   +1 more source

Metabotropic Glutamate Receptor Subtype 5 Antagonists MPEP and MTEP [PDF]

CNS Drug Reviews, 2006
ABSTRACTGlutamate regulates the function of central nervous system (CNS), in part, through the cAMP and/or IP3/DAG second messenger‐associated metabotropic glutamate receptors (mGluRs). The mGluR5 antagonist 2‐methyl‐6‐(phenylethynyl)‐pyridine (MPEP) has been extensively used to elucidate potential physiological and pathophysiological functions of ...
Alan I. Faden, Paul M Lea
openaire   +3 more sources

Infrared Neural Stimulation Elicits Distinct Molecular Pathways in Astrocytes Based on Laser Pulse Parameters

Advanced Biology, EarlyView.
Infrared (IR) light evokes distinct calcium and water transport responses in astrocytes, depending on stimulation duration and protocol. This study uses widefield imaging and pharmacology to reveal differential engagement of astroglial signaling pathways.
Wilson R. Adams, Ana I Borrachero‐Conejo, Pratheepa Kumari Rasiah, Emanuella Saracino, Roberto Zamboni, Eric Duco Jansen, Valentina Benfenati, Anita Mahadevan‐Jansen   +7 more
wiley   +1 more source

Metabotropic glutamate receptor 5 deficiency inhibits neutrophil infiltration after traumatic brain injury in mice

Scientific Reports, 2017
Both brain native inflammatory cells and infiltrated peripheral white blood cells (WBCs) are primary participants in the brain inflammatory damage post-TBI.
Ting Yang, Yang-Wuyue Liu, Li Zhao, Hao Wang, Nan Yang, S. Dai, F. He   +6 more
semanticscholar   +1 more source

Neuro‐Cancer Interactions Shape Glioma Intratumoral Heterogeneity

Advanced Science, EarlyView.
This review proposes a conceptual framework for understanding glioma intratumoral heterogeneity shaped by neuro‐cancer interactions: functional patterns and transcriptional states. Functional patterns manifest as three major neural‐like adaptations with spatial and potentially hierarchical relationships, including neurogliomal synapses, glioma networks,
Tong Wu, Peiran Zhao, Zheng Chen, Tianlei Ying, Zhihong Nie, Wei Hua, Huiyan Li, Ying Mao, Wenbo Bu   +8 more
wiley   +1 more source