Novel expression patterns of metabotropic glutamate receptor 6 in the zebrafish nervous system. [PDF]
PLoS ONE, 2012 The metabotropic glutamate receptor 6 (mGluR6 or GRM6) belongs to the class III of the metabotropic glutamate receptor family. It is the only known mGluR that mediates direct synaptic transmission in the nervous system and is thought to mediate the ON ...
Ying-Yu Huang +3 more
doaj +6 more sources
The Cold Case of Metabotropic Glutamate Receptor 6: Unjust Detention in the Retina? [PDF]
Curr Neuropharmacol, 2020 It is a common opinion that metabotropic glutamate receptor subtype 6 (mGluR6) is expressed exclusively in the retina, and in particular in the dendrites of ON-bipolar cells. Glutamate released in darkness from photoreceptors activates mGluR6, which is negatively associated with a membrane non-selective cation channel, the transient receptor potential ...
Palazzo E +5 more
europepmc +7 more sources
Neurobiology of Disease, 2021 Group I metabotropic glutamate receptors (mGluRs), mGluR1 and mGluR5, in the spinal cord are implicated in nociceptive transmission and plasticity through G protein-mediated second messenger cascades leading to the activation of various protein kinases ...
Akiko Ito +6 more
doaj +4 more sources
Metabotropic glutamate receptor 6 signaling enhances
Pigment Cell & Melanoma Research, 2013 SummaryMutations in TRPM1, a calcium channel expressed in retinal bipolar cells and epidermal melanocytes, cause complete congenital stationary night blindness with no discernible skin phenotype. In the retina, TRPM1 activity is negatively coupled to metabotropic glutamate receptor 6 (mGluR6) signaling through Gαo and TRPM1 mutations result in the loss
Sulochana Devi +6 more
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Role of Conserved Transmembrane Domain Cysteines in Activation of Metabotropic Glutamate Receptor Subtype 6 [PDF]
Medicinal chemistry, 2012 Metabotropic glutamate receptor subtype 6 (mGluR6) is a Class C type G protein coupled receptor (GPCR) uniquely expressed on retinal bipolar cells. mGluR6 plays a key role in dim-light vision but little is known about its structure and function. Here, we characterized the role of the three transmembrane (TM) cysteines in activation through site ...
Kalyan Tirupula
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Immunohistological Studies of Metabotropic Glutamate Receptor Subtype 6-Deficient Mice Show No Abnormality of Retinal Cell Organization and Ganglion Cell Maturation [PDF]
The Journal of Neuroscience, 1999 Immature retinal ganglion cells (RGCs) initially show a multistratified dendritic pattern, and, during the postnatal period, these dendrites gradually monostratify into ON and OFF sublaminae. The selective agonist of group III metabotropic glutamate receptors (mGluR),l-2-amino-4-phosphonobutyrate (l-AP-4), hyperpolarizes ON bipolar cells and reduces ...
Yoshiaki Tagawa +4 more
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Expression and functional characterization of Metabotropic Glutamate Receptor Type 6 (mGluR6) in detergent micelles [PDF]
Biophysical Journal, 2009 Metabotropic glutamate receptors (mGluRs) are G protein coupled receptors which are implicated in different brain functions and dysfunctions including learning, memory, pain perception, neurodegeneration, schizophrenia and addiction. Metabotropic glutamate receptor type 6 (mGluR6) is a subtype of mGluRs which is exclusively expressed in ON-bipolar ...
Kalyan Tirupula +3 more
openalex +2 more sources
Discovery of 4-alkoxy-6-methylpicolinamide negative allosteric modulators of metabotropic glutamate receptor subtype 5 [PDF]
Bioorganic & Medicinal Chemistry Letters, 2018 This letter describes the further chemical optimization of VU0424238 (auglurant), an mGlu5 NAM clinical candidate that failed in non-human primate (NHP) 28 day toxicology due to accumulation of a species-specific aldehyde oxidase (AO) metabolite of the pyrimidine head group.
Andrew S. Felts +11 more
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Chronic interleukin‐6 exposure alters metabotropic glutamate receptor‐activated calcium signalling in cerebellar Purkinje neurons [PDF]
European Journal of Neuroscience, 2004 AbstractChronic central nervous system expression of the cytokine interleukin‐6 (IL‐6) is thought to contribute to the histopathological, pathophysiological, and cognitive deficits associated with various neurological disorders. However, the effects of chronic IL‐6 expression on neuronal function are largely unknown.
Thomas E. Nelson +2 more
openalex +3 more sources