Novel expression patterns of metabotropic glutamate receptor 6 in the zebrafish nervous system. [PDF]
PLoS ONE, 2012 The metabotropic glutamate receptor 6 (mGluR6 or GRM6) belongs to the class III of the metabotropic glutamate receptor family. It is the only known mGluR that mediates direct synaptic transmission in the nervous system and is thought to mediate the ON ...
Ying-Yu Huang +3 more
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The Cold Case of Metabotropic Glutamate Receptor 6: Unjust Detention in the Retina? [PDF]
Curr Neuropharmacol, 2020 Palazzo E +5 more
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Neurobiology of Disease, 2021 Group I metabotropic glutamate receptors (mGluRs), mGluR1 and mGluR5, in the spinal cord are implicated in nociceptive transmission and plasticity through G protein-mediated second messenger cascades leading to the activation of various protein kinases ...
Akiko Ito +6 more
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Involvement of metabotropic glutamate receptor 5, AKT/PI3K Signaling and NF-κB pathway in methamphetamine-mediated increase in IL-6 and IL-8 expression in astrocytes [PDF]
Journal of Neuroinflammation, 2012 Methamphetamine (MA) is one of the commonly used illicit drugs and the central nervous system toxicity of MA is well documented. The mechanisms contributing to this toxicity have not been fully elucidated.
Shah Ankit +3 more
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Molecular docking studies of N-substituted 4-methoxy-6-oxo-1-aryl-pyridazine-3-carboxamide derivatives as potential modulators of glutamate receptors [PDF]
Research Results in Pharmacology, 2020 Introduction: The virtual target-oriented screening is a necessary stage of modern drug-design. In the present study, the affinity of pyridazine derivatives for the most promising antiparkinsonian biotargets – I–III groups of metabotropic and ionotropic ...
Hanna I. Severina +5 more
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Astrocyte activation in the anterior cingulate cortex and altered glutamatergic gene expression during paclitaxel-induced neuropathic pain in mice [PDF]
PeerJ, 2015 Spinal astrocyte activation contributes to the pathogenesis of paclitaxel-induced neuropathic pain (PINP) in animal models. We examined glial fibrillary acidic protein (GFAP; an astrocyte marker) immunoreactivity and gene expression of GFAP, glutamate ...
Willias Masocha
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Frontiers in Psychiatry, 2023 IntroductionIncubation of drug-craving refers to a time-dependent increase in drug cue-elicited craving that occurs during protracted withdrawal.
Laura L. Huerta Sanchez +12 more
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Orofacial antinociceptive activity and anchorage molecular mechanism in silico of geraniol [PDF]
Brazilian Oral Research, 2020 We aimed to evaluate the orofacial antinociceptive effect of geraniol in mice and its molecular anchorage mechanism. Seven mice per group (probabilistic sample) were treated with geraniol (12.5, 25 and 50 mg/kg, i.p.), morphine (6 mg/kg, i.p.) and ...
Tereza Karla Vieira Lopes da COSTA +9 more
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Can Metabotropic Glutamate Receptor 7 (mGluR 7) be a Novel Target for Analgesia? [PDF]
Journal of Clinical and Diagnostic Research, 2014 Introduction: The present study was carried out to study the role of metabotropic glutamate receptor 7 (mGluR7) using its agonist, N,N’-bis(diphenylmethyl)-1,-ethanediamine (AMN082) for nociceptive stimuli, in animal models.
Shivaprakash G +6 more
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Topological analysis of small leucine-rich repeat proteoglycan nyctalopin. [PDF]
PLoS ONE, 2012 Nyctalopin is a small leucine rich repeat proteoglycan (SLRP) whose function is critical for normal vision. The absence of nyctalopin results in the complete form of congenital stationary night blindness.
Pasano Bojang, Ronald G Gregg
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