Results 1 to 10 of about 44,093 (262)

Novel expression patterns of metabotropic glutamate receptor 6 in the zebrafish nervous system. [PDF]

PLoS ONE, 2012
The metabotropic glutamate receptor 6 (mGluR6 or GRM6) belongs to the class III of the metabotropic glutamate receptor family. It is the only known mGluR that mediates direct synaptic transmission in the nervous system and is thought to mediate the ON ...
Ying-Yu Huang, Marion F Haug, Matthias Gesemann, Stephan C F Neuhauss   +3 more
doaj   +8 more sources

The Cold Case of Metabotropic Glutamate Receptor 6: Unjust Detention in the Retina? [PDF]

Curr Neuropharmacol, 2020
It is a common opinion that metabotropic glutamate receptor subtype 6 (mGluR6) is expressed exclusively in the retina, and in particular in the dendrites of ON-bipolar cells.
Palazzo E, Boccella S, Marabese I, Pierretti G, Guida F, Maione S.   +5 more
europepmc   +7 more sources

A Retinal-Specific Regulator of G-Protein Signaling Interacts with Gαo and Accelerates an Expressed Metabotropic Glutamate Receptor 6 Cascade [PDF]

The Journal of Neuroscience, 2004
Go is the most abundant G-protein in the brain, but its regulators are essentially unknown. In retina, Gαo1 is obligatory in mediating the metabotropic glutamate receptor 6 (mGluR6)-initiated ON response. To identify the interactors of Go, we conducted a
A. Dhingra, E. Faurobert, N. Dascal, P. Sterling, N. Vardi   +4 more
semanticscholar   +6 more sources

Metabotropic Glutamate Receptor 6 [PDF]

Definitions, 2020

semanticscholar   +3 more sources

Cytohesin-2 mediates group I metabotropic glutamate receptor-dependent mechanical allodynia through the activation of ADP ribosylation factor 6 in the spinal cord

Neurobiology of Disease, 2021
Group I metabotropic glutamate receptors (mGluRs), mGluR1 and mGluR5, in the spinal cord are implicated in nociceptive transmission and plasticity through G protein-mediated second messenger cascades leading to the activation of various protein kinases ...
Akiko Ito, Masahiro Fukaya, Takeyuki Sugawara, Yoshinobu Hara, Hirotsugu Okamoto, Junji Yamauchi, Hiroyuki Sakagami   +6 more
doaj   +5 more sources

Identification of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Acting at Site Distinct from 2-Methyl-6-(phenylethynyl)-pyridine Binding

ACS Chemical Neuroscience, 2019
As part of the G-protein coupled receptor (GPCR) family, metabotropic glutamate (mGlu) receptors play an important role as drug targets of cognitive diseases.
Mariusz Butkiewicz, Alice L. Rodriguez, Shane E. Rainey, Joshua M. Wieting, Vincent B Luscombe, S. Stauffer, C. Lindsley, P. Conn, J. Meiler   +8 more
semanticscholar   +6 more sources

Metabotropic glutamate receptor 6 signaling enhances TRPM1 calcium channel function and increases melanin content in human melanocytes [PDF]

Pigment Cell & Melanoma Research, 2013
SummaryMutations in TRPM1, a calcium channel expressed in retinal bipolar cells and epidermal melanocytes, cause complete congenital stationary night blindness with no discernible skin phenotype. In the retina, TRPM1 activity is negatively coupled to metabotropic glutamate receptor 6 (mGluR6) signaling through Gαo and TRPM1 mutations result in the loss
S. Devi, Yogananda S. Markandeya, Nityanand Maddodi, A. Dhingra, N. Vardi, Ravi C Balijepalli, V. Setaluri   +6 more
semanticscholar   +5 more sources

Involvement of metabotropic glutamate receptor 5, AKT/PI3K Signaling and NF-κB pathway in methamphetamine-mediated increase in IL-6 and IL-8 expression in astrocytes [PDF]

Journal of Neuroinflammation, 2012
Methamphetamine (MA) is one of the commonly used illicit drugs and the central nervous system toxicity of MA is well documented. The mechanisms contributing to this toxicity have not been fully elucidated.
Shah Ankit, Silverstein Peter S, Singh Dhirendra P, Kumar Anil   +3 more
doaj   +7 more sources

Negative Modulation of the Metabotropic Glutamate Receptor Type 5 as a Potential Therapeutic Strategy in Obesity and Binge-Like Eating Behavior

Frontiers in Neuroscience, 2021
Obesity is a multifactorial disease, which in turn contributes to the onset of comorbidities, such as diabetes and atherosclerosis. Moreover, there are only few options available for treating obesity, and most current pharmacotherapy causes severe ...
Tadeu P. D. Oliveira, Bruno D. C. Gonçalves, Bruna S. Oliveira, Antonio Carlos P. de Oliveira, Helton J. Reis, Claudia N. Ferreira, Daniele C. Aguiar, Aline S. de Miranda, Fabiola M. Ribeiro, Erica M. L. Vieira, András Palotás, András Palotás, Luciene B. Vieira   +12 more
doaj   +2 more sources

Artesunate Alleviates Paclitaxel-Induced Neuropathic Pain in Mice by Decreasing Metabotropic Glutamate Receptor 5 Activity and Neuroinflammation in Primary Sensory Neurons

Frontiers in Molecular Neuroscience, 2022
Experimental studies on the pathogenetic process of paclitaxel-induced neuropathic pain (PINP) have been initially carried out, but PINP still has no effective therapy. Recently reported studies have highlighted the involvement of glutamate receptors and
Yize Li, Jiamin Kang, Ying Xu, Nan Li, Yang Jiao, Chenxu Wang, Chunyan Wang, Guolin Wang, Yonghao Yu, Jingjing Yuan, Linlin Zhang   +10 more
doaj   +2 more sources