Novel expression patterns of metabotropic glutamate receptor 6 in the zebrafish nervous system. [PDF]
PLoS ONE, 2012 The metabotropic glutamate receptor 6 (mGluR6 or GRM6) belongs to the class III of the metabotropic glutamate receptor family. It is the only known mGluR that mediates direct synaptic transmission in the nervous system and is thought to mediate the ON ...
Ying-Yu Huang +3 more
doaj +8 more sources
The Cold Case of Metabotropic Glutamate Receptor 6: Unjust Detention in the Retina? [PDF]
Curr Neuropharmacol, 2020 It is a common opinion that metabotropic glutamate receptor subtype 6 (mGluR6) is expressed exclusively in the retina, and in particular in the dendrites of ON-bipolar cells. Glutamate released in darkness from photoreceptors activates mGluR6, which is negatively associated with a membrane non-selective cation channel, the transient receptor potential ...
Palazzo E +5 more
europepmc +7 more sources
A Retinal-Specific Regulator of G-Protein Signaling Interacts with Gαoand Accelerates an Expressed Metabotropic Glutamate Receptor 6 Cascade [PDF]
The Journal of Neuroscience, 2004 Gois the most abundant G-protein in the brain, but its regulators are essentially unknown. In retina, Gαo1is obligatory in mediating the metabotropic glutamate receptor 6 (mGluR6)-initiated ON response. To identify the interactors of Go, we conducted a yeast two-hybrid screen with constituitively active Gαoas a bait.
Anuradha Dhingra +4 more
semanticscholar +6 more sources
Metabotropic glutamate receptor 6 signaling enhances
Pigment Cell & Melanoma Research, 2013 SummaryMutations in TRPM1, a calcium channel expressed in retinal bipolar cells and epidermal melanocytes, cause complete congenital stationary night blindness with no discernible skin phenotype. In the retina, TRPM1 activity is negatively coupled to metabotropic glutamate receptor 6 (mGluR6) signaling through Gαo and TRPM1 mutations result in the loss
Sulochana Devi +6 more
semanticscholar +5 more sources
Neurobiology of Disease, 2021 Group I metabotropic glutamate receptors (mGluRs), mGluR1 and mGluR5, in the spinal cord are implicated in nociceptive transmission and plasticity through G protein-mediated second messenger cascades leading to the activation of various protein kinases ...
Akiko Ito +6 more
doaj +5 more sources
ACS Chemical Neuroscience, 2019 As part of the G-protein coupled receptor (GPCR) family, metabotropic glutamate (mGlu) receptors play an important role as drug targets of cognitive diseases. Selective allosteric modulators of mGlu subtype 5 (mGlu5) have the potential to alleviate symptoms of numerous central nervous system disorders such as schizophrenia in a more targeted fashion ...
Mariusz Butkiewicz +8 more
semanticscholar +6 more sources
Involvement of metabotropic glutamate receptor 5, AKT/PI3K Signaling and NF-κB pathway in methamphetamine-mediated increase in IL-6 and IL-8 expression in astrocytes [PDF]
Journal of Neuroinflammation, 2012 Methamphetamine (MA) is one of the commonly used illicit drugs and the central nervous system toxicity of MA is well documented. The mechanisms contributing to this toxicity have not been fully elucidated.
Shah Ankit +3 more
doaj +7 more sources
Discovery of 4-alkoxy-6-methylpicolinamide negative allosteric modulators of metabotropic glutamate receptor subtype 5 [PDF]
Bioorganic & Medicinal Chemistry Letters, 2018 This letter describes the further chemical optimization of VU0424238 (auglurant), an mGlu5 NAM clinical candidate that failed in non-human primate (NHP) 28 day toxicology due to accumulation of a species-specific aldehyde oxidase (AO) metabolite of the pyrimidine head group.
Andrew S. Felts +11 more
openalex +4 more sources
Role of Conserved Transmembrane Domain Cysteines in Activation of Metabotropic Glutamate Receptor Subtype 6 [PDF]
Medicinal chemistry, 2012 Metabotropic glutamate receptor subtype 6 (mGluR6) is a Class C type G protein coupled receptor (GPCR) uniquely expressed on retinal bipolar cells. mGluR6 plays a key role in dim-light vision but little is known about its structure and function. Here, we characterized the role of the three transmembrane (TM) cysteines in activation through site ...
Kalyan Tirupula
openalex +3 more sources