Results 31 to 40 of about 48,931 (264)

mGlu1 Receptors Monopolize the Synaptic Control of Cerebellar Purkinje Cells by Epigenetically Down-Regulating mGlu5 Receptors [PDF]

, 2018
In cerebellar Purkinje cells (PCs) type-1 metabotropic glutamate (mGlu1) receptors play a key role in motor learning and drive the refinement of synaptic innervation during postnatal development.
Atsu Aiba, Cristina Zappulla, Ferdinando Nicoletti, Francesca Liberatore, Giada Mascio, Giorgio Carmignoto, Giuseppe Battaglia, Harumi Nakao, Marta Motolese, Masahiko Watanabe, Micaela Zonta, Michele Madonna, Milena Cannella, Pamela Scarselli, Roberto Gradini, Serena Notartomaso, Valeria Bruno   +16 more
core   +2 more sources

Antipsychotic profiles of TASP0443294, a novel and orally active positive allosteric modulator of metabotropic glutamate 2 receptor

Journal of Pharmacological Sciences, 2015
Glutamatergic dysfunction has been implicated in psychiatric disorders such as schizophrenia. The stimulation of metabotropic glutamate (mGlu) 2 receptor has been shown to be effective in a number of animal models of schizophrenia.
Hirohiko Hikichi, Tetsuaki Hiyoshi, Toshiyuki Marumo, Yasumitsu Tomishima, Ayaka Kaku, Izumi Iida, Hiroki Urabe, Tomoko Tamita, Akito Yasuhara, Jun-ichi Karasawa, Shigeyuki Chaki   +10 more
doaj   +1 more source

Negative Modulation of the Metabotropic Glutamate Receptor Type 5 as a Potential Therapeutic Strategy in Obesity and Binge-Like Eating Behavior

Frontiers in Neuroscience, 2021
Obesity is a multifactorial disease, which in turn contributes to the onset of comorbidities, such as diabetes and atherosclerosis. Moreover, there are only few options available for treating obesity, and most current pharmacotherapy causes severe ...
Tadeu P. D. Oliveira, Bruno D. C. Gonçalves, Bruna S. Oliveira, Antonio Carlos P. de Oliveira, Helton J. Reis, Claudia N. Ferreira, Daniele C. Aguiar, Aline S. de Miranda, Fabiola M. Ribeiro, Erica M. L. Vieira, András Palotás, András Palotás, Luciene B. Vieira   +12 more
doaj   +1 more source

Metabotropic glutamate 2/3 receptors and epigenetic modifications in psychotic disorders: a review [PDF]

, 2016
Schizophrenia and Bipolar Disorder are chronic psychiatric disorders, both considered as "major psychosis"; they are thought to share some pathogenetic factors involving a dysfunctional gene x environment interaction.
Grayson, Danis R, Guidotti, Alessandro, MATRISCIANO, FRANCESCO, NICOLETTI, Ferdinando, PANACCIONE, ISABELLA   +4 more
core   +2 more sources

Metabotropic glutamate receptor 2/3 (mGluR2/3) activation suppresses TRPV1 sensitization in mouse, but not human sensory neurons [PDF]

, 2018
The use of human tissue to validate putative analgesic targets identified in rodents is a promising strategy for improving the historically poor translational record of preclinical pain research.
Baranger, David A.A., Gereau, Robert W, McIlvried, Lisa V, Pullen, Melanie Y, Sheahan, Tayler D, Valtcheva, Manouela V   +5 more
core   +2 more sources

Paeonol Protection Against Intrastriatal 6-Hydroxydopamine Rat Model of Parkinson\'s Disease

Basic and Clinical Neuroscience, 2021
Introduction: Parkinsonchr('39')s disease (PD) presentations comprise frequent movement disorders in the elderly with various symptoms consisting of motor and non-motor complications.
Jamileh Ghalami, Tourandokht Baluchnejad Mojarad, Monireh Mansouri, Safoura Khamse, Mehrdad Roghani   +4 more
doaj  

Optogenetics-induced activation of glutamate receptors improves memory function in mice with Alzheimer’s disease

Neural Regeneration Research, 2019
Optogenetics is a combination of optics and genetics technology that can be used to activate or inhibit specific cells in tissues. It has been used to treat Parkinson’s disease, epilepsy and neurological diseases, but rarely Alzheimer’s disease.
Ke-Wei Wang, Xiao-Lin Ye, Ting Huang, Xi-Fei Yang, Liang-Yu Zou   +4 more
doaj   +1 more source

Targeting mGlu5 metabotropic glutamate receptors in the treatment of cognitive dysfunction in a mouse model of phenylketonuria [PDF]

, 2018
We studied group-I metabotropic glutamate (mGlu) receptors in Pah(enu2) (ENU2) mice, which mimic the genetics and neurobiology of human phenylketonuria (PKU), a metabolic disorder characterized, if untreated, by autism, and intellectual disability (ID ...
Battaglia, Giuseppe, Colamartino, Marco, Di Menna, Luisa, Fiori, Elena, Iacovelli, Luisa, Leuzzi, Vincenzo, Nardecchia, Francesca, Nicoletti, Ferdinando, Nistico, Robert, Orlando, Rosamaria, Pascucci, Tiziana, Piccinin, Sonia, Puglisi-Allegra, Stefano   +12 more
core   +2 more sources

Mechanisms associated with activation of intracellular metabotropic glutamate receptor, mGluR5 [PDF]

, 2016
The group 1 metabotropic glutamate receptor, mGluR5, is found on the cell surface as well as on intracellular membranes where it can mediate both overlapping and unique signaling effects.
Jong, Yuh-Jiin I, O\u27Malley, Karen L
core   +2 more sources

Bioactive Benzofuran Derivatives from Cortex Mori Radicis, and Their Neuroprotective and Analgesic Activities Mediated by mGluR1

Molecules, 2017
Four new benzofuran-type stilbene glycosides and 14 known compounds including 8 benzofuran-type stilbenes and 6 flavonoids were isolated from the traditional Chinese medicine, Cortex Mori Radicis.
Ya-Nan Wang, Mao-Feng Liu, Wei-Zhen Hou, Rui-Ming Xu, Jie Gao, An-Qi Lu, Mei-Ping Xie, Lan Li, Jian-Jun Zhang, Ying Peng, Li-Li Ma, Xiao-Liang Wang, Jian-Gong Shi, Su-Juan Wang   +13 more
doaj   +1 more source