Results 31 to 40 of about 44,093 (262)

Antipsychotic profiles of TASP0443294, a novel and orally active positive allosteric modulator of metabotropic glutamate 2 receptor

Journal of Pharmacological Sciences, 2015
Glutamatergic dysfunction has been implicated in psychiatric disorders such as schizophrenia. The stimulation of metabotropic glutamate (mGlu) 2 receptor has been shown to be effective in a number of animal models of schizophrenia.
Hirohiko Hikichi, Tetsuaki Hiyoshi, Toshiyuki Marumo, Yasumitsu Tomishima, Ayaka Kaku, Izumi Iida, Hiroki Urabe, Tomoko Tamita, Akito Yasuhara, Jun-ichi Karasawa, Shigeyuki Chaki   +10 more
doaj   +1 more source

Optogenetics-induced activation of glutamate receptors improves memory function in mice with Alzheimer’s disease

Neural Regeneration Research, 2019
Optogenetics is a combination of optics and genetics technology that can be used to activate or inhibit specific cells in tissues. It has been used to treat Parkinson’s disease, epilepsy and neurological diseases, but rarely Alzheimer’s disease.
Ke-Wei Wang, Xiao-Lin Ye, Ting Huang, Xi-Fei Yang, Liang-Yu Zou   +4 more
doaj   +1 more source

Paeonol Protection Against Intrastriatal 6-Hydroxydopamine Rat Model of Parkinson\'s Disease

Basic and Clinical Neuroscience, 2021
Introduction: Parkinsonchr('39')s disease (PD) presentations comprise frequent movement disorders in the elderly with various symptoms consisting of motor and non-motor complications.
Jamileh Ghalami, Tourandokht Baluchnejad Mojarad, Monireh Mansouri, Safoura Khamse, Mehrdad Roghani   +4 more
doaj  

Distinct Subunits in Heteromeric Kainate Receptors Mediate Ionotropic and Metabotropic Function at Hippocampal Mossy Fiber Synapses

Journal of Neuroscience, 2005
Heteromeric kainate receptors (KARs) containing both glutamate receptor 6 (GluR6) and KA2 subunits are involved in KAR-mediated EPSCs at mossy fiber synapses in CA3 pyramidal cells.
Arnaud Ruiz, Shankar Sachidhanandam, J. Utvik, F. Coussen, C. Mulle   +4 more
semanticscholar   +1 more source

Bioactive Benzofuran Derivatives from Cortex Mori Radicis, and Their Neuroprotective and Analgesic Activities Mediated by mGluR1

Molecules, 2017
Four new benzofuran-type stilbene glycosides and 14 known compounds including 8 benzofuran-type stilbenes and 6 flavonoids were isolated from the traditional Chinese medicine, Cortex Mori Radicis.
Ya-Nan Wang, Mao-Feng Liu, Wei-Zhen Hou, Rui-Ming Xu, Jie Gao, An-Qi Lu, Mei-Ping Xie, Lan Li, Jian-Jun Zhang, Ying Peng, Li-Li Ma, Xiao-Liang Wang, Jian-Gong Shi, Su-Juan Wang   +13 more
doaj   +1 more source

MGlu5 Dependent Mitochondrial Translocation of PKCδ: A Mechanism Raising Astrocytic Oxidative Metabolism in Response to Extracellular Glutamate. [PDF]

J Neurochem
The observations suggest a new mechanism, the mGluR5/PKCδ/PDH axis by which extracellular glutamate can raise oxidative metabolism in astrocytes, in response to rapidly increasing energy demands, such as in the liver or skeletal muscle. It appears that the plethora of astrocytic mitochondria maintain only a basal level of oxidative metabolism during ...
Farid KMN, Lerchundi R, Rose CR, Derouiche A.   +3 more
europepmc   +2 more sources

Involvement of the C‐terminal domain in cell surface localization and G‐protein coupling of mGluR6

Journal of Neurochemistry, 2020
Metabotropic glutamate receptor 6, mGluR6, interacts with scaffold proteins and Gβγ subunits via its intracellular C‐terminal domain (CTD). The mGluR6 pathway is critically involved in the retinal processing of visual signals.
Dilip Rai, T. Akagi, A. Shimohata, Toshiyuki Ishii, Mie Gangi, Takuma Maruyama, Y. Wada‐Kiyama, I. Ogiwara, M. Kaneda   +8 more
semanticscholar   +1 more source

Metabotropic glutamate receptor 5-related autoimmune encephalitis with reversible splenial lesion syndrome following SARS-CoV-2 vaccination

Medicine, 2023
Rationale: Metabotropic glutamate receptor 5 (mGluR5)-related autoimmune encephalitis (AE) has been rarely reported; however, there are no reports on mGluR5-related AE with reversible splenial lesion syndrome following vaccination against severe acute ...
Yu Zhang, Baorong Lian, Shi-Yan Yang, Xuming Huang, Yanxia Zhou, Liming Cao   +5 more
semanticscholar   +1 more source

Neuroprotection and Functional Recovery Associated with Decreased Microglial Activation Following Selective Activation of mGluR2/3 Receptors in a Rodent Model of Parkinson's Disease

Parkinson's Disease, 2010
Clinical trials have demonstrated positive proof of efficacy of dual metabotropic glutamate receptor 2/3 (mGluR2/3) agonists in both anxiety and schizophrenia.
Hugh Chan, Helen Paur, Anthony C. Vernon, Virginia Zabarsky, Krishna P. Datla, Martin J. Croucher, David T. Dexter   +6 more
doaj   +1 more source

mGluR5-antagonist mediated reversal of elevated stereotyped, repetitive behaviors in the VPA model of autism. [PDF]

PLoS ONE, 2011
Autism spectrum disorders (ASD) are highly disabling developmental disorders with a population prevalence of 1-3%. Despite a strong genetic etiology, there are no current therapeutic options that target the core symptoms of ASD.
Mili V Mehta, Michael J Gandal, Steven J Siegel   +2 more
doaj   +1 more source