Results 41 to 50 of about 69,647 (248)

From bench to bedside: The mGluR5 system in people with and without Autism Spectrum Disorder and animal model systems

Translational Psychiatry, 2022
The metabotropic glutamate receptor 5 (mGluR5) is a key regulator of excitatory (E) glutamate and inhibitory (I) γ-amino butyric acid (GABA) signalling in the brain. Despite the close functional ties between mGluR5 and E/I signalling, no-one has directly
Cornelia Carey, Nisha Singh, Joel T. Dunn, Teresa Sementa, Maria Andreina Mendez, Hester Velthuis, Andreia C. Pereira, Charlotte Marie Pretzsch, Jamie Horder, Stefan Hader, David J. Lythgoe, Diana-Georgina Rotaru, Anthony Gee, Diana Cash, Mattia Veronese, Declan Murphy, Grainne McAlonan   +16 more
doaj   +1 more source

Genetic Deletion of mGlu3 Metabotropic Glutamate Receptors Amplifies Ischemic Brain Damage and Associated Neuroinflammation in Mice

Frontiers in Neurology, 2021
Backgroud: Type-3 metabotropic glutamate (mGlu3) receptors are found in both neurons and glial cells and regulate synaptic transmission, astrocyte function, and microglial reactivity.
Federica Mastroiacovo, Manuela Zinni, Giada Mascio, Valeria Bruno, Valeria Bruno, Giuseppe Battaglia, Giuseppe Battaglia, Julien Pansiot, Tiziana Imbriglio, Jerome Mairesse, Jerome Mairesse, Olivier Baud, Olivier Baud, Olivier Baud, Ferdinando Nicoletti, Ferdinando Nicoletti   +15 more
doaj   +1 more source

Design, synthesis, and characterization of [18F]mG2P026 as a high contrast PET imaging ligand for metabotropic glutamate receptor 2

bioRxiv, 2021
An array of triazolopyridines based on JNJ-46356479 (6) were synthesized as potential PET imaging ligands for metabotropic glutamate receptor 2 (mGluR2) in the brain.
Gengyang Yuan, M. Dhaynaut, N. Guehl, S. Afshar, Dalena Huynh, Sung-Hyun Moon, Suhasini M Iyengar, H. Kang, M. Ondrechen, G. Fakhri, M. Normandin, A. Brownell   +11 more
semanticscholar   +1 more source

Grape seed proanthocyanidin extract inhibits glutamate-induced cell death through inhibition of calcium signals and nitric oxide formation in cultured rat hippocampal neurons

BMC Neuroscience, 2011
Background Proanthocyanidin is a polyphenolic bioflavonoid with known antioxidant activity. Some flavonoids have a modulatory effect on [Ca2+]i. Although proanthocyanidin extract from blueberries reportedly affects Ca2+ buffering capacity, there are no ...
Kim Myung-Jun, Hong Yi, Jeong Imju, Kim Hee, Ahn Seo-Hee, Rhie Duck-Joo, Jo Yang-Hyeok, Hahn Sang, Yoon Shin   +8 more
doaj   +1 more source

Integration and regulation of glomerular inhibition in the cerebellar granular layer circuit

Frontiers in Cellular Neuroscience, 2014
Inhibitory synapses can be organized in different ways and be regulated by a multitude of mechanisms. One of the best known examples is provided by the inhibitory synapses formed by Golgi cells onto granule cells in the cerebellar glomeruli.
Lisa eMapelli, Lisa eMapelli, Sergio eSolinas, Sergio eSolinas, Egidio eD‘Angelo, Egidio eD‘Angelo   +5 more
doaj   +1 more source

The regulatory role of NAAG-mGluR3 signaling on cortical synaptic plasticity after hypoxic ischemia

Cell Communication and Signaling, 2022
Background Synapses can adapt to changes in the intracerebral microenvironment by regulation of presynaptic neurotransmitter release and postsynaptic neurotransmitter receptor expression following hypoxic ischemia (HI) injury.
Kexin Li, Meng Lu, Mengxu Cui, Xiaoming Wang, Yang Zheng   +4 more
doaj   +1 more source

Update in Autoimmune Movement Disorders: Newly Described Antigen Targets in Autoimmune and Paraneoplastic Cerebellar Ataxia

Frontiers in Neurology, 2021
Movement disorders are a common feature of many antibody-associated neurological disorders. In fact, cerebellar ataxia is one of the most common manifestations of autoimmune neurological diseases.
Madeline Garza, Amanda L. Piquet
doaj   +1 more source

The Light Response of ON Bipolar Neurons Requires Gαo

Journal of Neuroscience, 2000
ON bipolar neurons in retina detect the glutamate released by rods and cones via metabotropic glutamate receptor 6 (mGluR6), whose cascade is unknown. The trimeric G-protein Go might mediate this cascade because it colocalizes with mGluR6.
A. Dhingra, A. Lyubarsky, M. Jiang, E. Pugh, L. Birnbaumer, P. Sterling, N. Vardi   +6 more
semanticscholar   +1 more source

Pharmacological And Genetic Reversal Of Age-Dependent Cognitive Deficits Attributable To Decreased Presenilin Function [PDF]

, 2010
Alzheimer\u27s disease (AD) is the leading cause of cognitive loss and neurodegeneration in the developed world. Although its genetic and environmental causes are not generally known, familial forms of the disease (FAD) are attributable to mutations in a
Bell, A. J., Chiorean, S., Choi, C. H., Choi, R. J., Ferreiro, D., Ferrick, N. J., Fortini, M. E., Hinchey, P., Jongens, T. A., Koenigsberg, E., Kollaros, M., Liebelt, D. A., McBride, S. M.J., McDonald, T. V., Nguyen, H. T., Rudominer, R. L., Schoenfeld, B. P., Siwicki, Kathleen King, Sumida, A., Terlizzi, A. M.   +19 more
core   +2 more sources

Involvement of serotonergic system in the effect of a metabotropic glutamate 5 receptor antagonist in the novelty-suppressed feeding test

Journal of Pharmacological Sciences, 2015
The blockade of metabotropic glutamate 5 (mGlu5) receptor has been reported to exert antidepressant effects in several animal models. We previously reported that both ketamine and an mGlu5 receptor antagonist exerted an effect in a novelty-suppressed ...
Kenichi Fukumoto, Shigeyuki Chaki
doaj   +1 more source