Results 61 to 70 of about 51,960 (263)

Nanoscale Mapping of the Subcellular Glycosylation Landscape

Advanced Science, EarlyView.
Using multiplexed super‐resolution imaging with fluorophore‐labeled lectins, this study reports intracellular glycosylation at the nanoscale across organelles and synaptic specializations. Extending glycan analysis beyond the cell surface, Glyco‐STORM reveals distinct glycosylation nanodomains in the ER, Golgi, lysosomes, and synaptic sites.
Helene Gregoria Schroeter, Steffen Sass, Mike Heilemann, Thomas Kuner, Maja Klevanski   +4 more
wiley   +1 more source

Deleterious GRM1 mutations in schizophrenia.

PLoS ONE, 2012
We analysed a phenotypically well-characterised sample of 450 schziophrenia patients and 605 controls for rare non-synonymous single nucleotide polymorphisms (nsSNPs) in the GRM1 gene, their functional effects and family segregation.
Mohammed Akli Ayoub, Dora Angelicheva, David Vile, David Chandler, Bharti Morar, Juleen A Cavanaugh, Peter M Visscher, Assen Jablensky, Kevin D G Pfleger, Luba Kalaydjieva   +9 more
doaj   +1 more source

Neurochemical Changes in the Mouse Hippocampus Underlying the Antidepressant Effect of Genetic Deletion of P2X7 Receptors. [PDF]

, 2013
Recent investigations have revealed that the genetic deletion of P2X7 receptors (P2rx7) results in an antidepressant phenotype in mice. However, the link between the deficiency of P2rx7 and changes in behavior has not yet been explored.
A McQuillin, A Scimemi, AA Boucher, AD Michel, AJ Law, AM Basso, AN Guerra, AV Gourine, B Sperlagh, B Sperlagh, B Sperlagh, Beáta Sperlágh, BP Guiard, C Csolle, C Delarasse, C Lavebratt, C Toro, C Verderio, Cecilia Csölle, CG Thomas, CM Anderson, DS Hasin, DT Balu, E Castren, E Fuchs, E Mundo, E Shimizu, E. Sylvester Vizi, Edit Papp, EJ Nestler, EK Green, F Frenois, F Karege, Flóra Gölöncsér, G Nagy, G Nowak, G Sanacora, G Sanacora, G Sanacora, Gabriella Zsilla, GE Hardingham, GE Wood, JE Malberg, JF Cryan, JF Cryan, JH Meador-Woodruff, JL Warner-Schmidt, JM Boyce-Rustay, JM Krueger, JO Groves, JS Barnholtz, K Hashimoto, K Hejjas, K Martinowich, K Viwatpinyo, K Wager-Smith, KR Tovar, L Backlund, L Bocchio-Chiavetto, L Papp, L Papp, L Patti, L Santarelli, L Stokes, L Zhang, LM Monteggia, M Baranyi, M Barbera-Cremades, M Diaz-Hernandez, M Grigoroiu-Serbanescu, M Koehl, M Masin, M Solle, ME Kozisek, ME Kozisek, ME Szapacs, ML Barbaccia, MT Miras-Portugal, MW Pfaffl, Mária Baranyi, N Barden, N Drigues, O Berton, OH Lowry, P Fossati, P Skolnick, P Soronen, P Vanhoutte, PA Lapchak, Peter Illes, R Dantzer, RC Hogg, RJ Griffiths, RJ Rodrigues, RS Duman, S Alloisio, S Duan, S Lucae, S Monleon, S Schnydrig, SN Williams, SP Banerjee, T Balazsa, T Deltheil, T Deltheil, T Zigova, Thierry Amédée, V Shukla, VF Labrousse, VM Brautigam, W Peng, Y Dwivedi, Y Shirayama, Z Hracskó, Ágnes Kittel   +114 more
core   +2 more sources

Vitamin D Regulates Olfactory Function via Dual Transcriptional and mTOR‐Dependent Translational Control of Synaptic Proteins

Advanced Science, EarlyView.
Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor‐dependent transcriptional and translational mechanisms. VitD regulates synaptic protein translation partially via mTOR signaling.
Pengcheng Ren, Renhe Cao, Xiaoshan Ye, Wenbin Pang, Qingshang Bi, Meihui Huang, Qionglin Zhou, Dan Ye, Wei Xiang, Le Xiao   +9 more
wiley   +1 more source

Age-Related Alterations in the Expression of Genes and Synaptic Plasticity Associated with Nitric Oxide Signaling in the Mouse Dorsal Striatum

Neural Plasticity, 2015
Age-related alterations in the expression of genes and corticostriatal synaptic plasticity were studied in the dorsal striatum of mice of four age groups from young (2-3 months old) to old (18–24 months of age) animals.
Aisa N. Chepkova, Susanne Schönfeld, Olga A. Sergeeva   +2 more
doaj   +1 more source

Enhancement of Short-Term Memory by Methyl-6-(Phenylethynyl)-Pyridine in the BTBR T+tf/J Mouse Model of Autism Spectrum Disorder [PDF]

Endocrinology and Metabolism, 2015
BackgroundAutism spectrum disorder (ASD) encompasses a range of disorders that are characterized by social and communication deficits and repetitive behaviors.
Haijie Yang, Sung-Oh Huh, Jae Seung Hong
doaj   +1 more source

Changes in the Number and Morphology of Dendritic Spines in the Hippocampus and Prefrontal Cortex of the C58/J Mouse Model of Autism

Frontiers in Cellular Neuroscience, 2021
Autism spectrum disorder (ASD) has a broad range of neurobiological characteristics, including alterations in dendritic spines, where approximately 90% of excitatory synapses occur.
Isabel Barón-Mendoza, Emely Maqueda-Martínez, Mónica Martínez-Marcial, Marisol De la Fuente-Granada, Margarita Gómez-Chavarin, Aliesha González-Arenas   +5 more
doaj   +1 more source

Determining the neurotransmitter concentration profile at active synapses [PDF]

, 2009
Establishing the temporal and concentration profiles of neurotransmitters during synaptic release is an essential step towards understanding the basic properties of inter-neuronal communication in the central nervous system.
A Barberis, A Scimemi, A Tao, A Triller, AE Spruce, AG Ogston, AI Gulyas, AM Aravanis, Annalisa Scimemi, AV Hill, B Barbour, B Ceccarelli, B Granseth, B Katz, C Auger, C Nicholson, C Nicholson, C Nicholson, C Racca, D Colquhoun, D Colquhoun, D Sulzer, DA Rusakov, DE Bergles, DM Kullmann, DR Copenhagen, E Betzig, E Neher, E Sykova, EL Botvinick, EN Pothos, EP Huang, F Asztely, F Pouille, G Brasnjo, G Liu, G Szapiro, G Tong, GH Acheson, GH Patterson, H Korn, H Korn, H Shroff, HC Hartzell, IM Raman, J Balaji, J Castillo Del, J Hrabe, J Matthews-Bellinger, J Szabadics, JC Eccles, JC Eccles, JC Eccles, JD Clements, JE Heuser, JH Singer, JI Wadiche, JI Wadiche, JJ Celentano, JM Bekkers, JM Christie, JM Fernandez, JR Stiles, JS Diamond, JS Diamond, JS Diamond, JW Mozrzymas, JW Mozrzymas, K Belaya, K Krnjevic, K Luby-Phelps, K Zheng, KA Foster, KE Sorra, KL Magleby, KM Franks, KP Lehre, L He, L Tao, LG Longsworth, LM Levy, LM Wahl, LP Savtchenko, LS Overstreet, M Beato, M Beato, M Beato, MA Medina, Marco Beato, MI Banks, MJ Higley, MV Jones, MY Min, N Arnth-Jensen, N Harata, N Riveros, NC Harata, O Prange, P Fatt, P Fatt, P Legendre, PJ Kruk, PM Burger, Q Zhang, Q Zhang, R Ando, R Conti, R Renden, R Ventura, RG Thorne, RH Chow, RM Wightman, RW Daniels, RY Tsien, S Habuchi, S Hrabetova, S Manley, S Namiki, S Okumoto, S Takamori, SA Hires, SJ Pitt, SP Gandhi, SW Kuffler, SY Breusegem, T Lu, T Schikorski, T Schikorski, TA Nielsen, TG Allen, TG Banke, TG Oertner, TM Bartol Jr, V Burzomato, VA Levin, W Almers, W Lu, X Chen, XS Wu, Y Dehnes, Y Takumi, YH Huang, Z Nusser, Z Petrasek, Z Petrasek   +144 more
core   +2 more sources

Uncovering the Lipid Interface in Neurotransmission: Single Molecule Measurements of Neurotransmitters Interacting with Membranes Reveal Species Dependent Membrane Binding

Advanced Science, EarlyView.
Using single‐molecule whispering gallery mode sensors, neurotransmitter‐specific membrane binding signatures are measured that reveal intrinsically distinct interaction kinetics and orientations on a lipid membrane. Abstract Neurotransmitters (NTs) have traditionally been understood to act via aqueous‐phase receptor binding, but growing evidence ...
Thomas L. Derrien, Aneeth Kakkanattu Arunkumar, Rosalind Cross, Emilie Sunnucks, Frank Vollmer   +4 more
wiley   +1 more source

Negative allosteric modulation of the mGlu7 receptor reduces visceral hypersensitivity in a stress-sensitive rat strain

Neurobiology of Stress, 2015
Glutamate, the main excitatory neurotransmitter in the central nervous system, exerts its effect through ionotropic and metabotropic receptors.
Rachel D. Moloney, Anna V. Golubeva, Richard M. O'Connor, Mikhail Kalinichev, Timothy G. Dinan, John F. Cryan   +5 more
doaj   +1 more source