Results 61 to 70 of about 48,931 (264)
Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy
Advanced Science, EarlyView.In ARHL, the stria vascularis, acting as a cochlear battery, gradually loses its ability to maintain the endocochlear potential, leading to impaired hair cell function and progressive hearing loss. Single‐cell sequencing reveals age‐related cellular changes in the cochlea, providing insights into the underlying mechanisms of aging and potential ...
Xiaoxu Zhao +12 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2021 Autism spectrum disorder (ASD) has a broad range of neurobiological characteristics, including alterations in dendritic spines, where approximately 90% of excitatory synapses occur.
Isabel Barón-Mendoza +5 more
doaj +1 more source
Pharmacological Research, 2017 Numerous epidemiological studies suggested that there is a variable cancer risk in patients with Parkinson's disease (PD). However, the underlying mechanisms remain unclear. In the present study, the role of metabotropic glutamate receptor 5 (mGluR5) has been investigated in 6-hydroxydopamine (6-OHDA)-induced PD combined with liver cancer both in vitro
Hui Min Yang +7 more
openaire +3 more sources
Advanced Science, EarlyView.DNA‐Based Genetic and Non‐Genetic Tools for Receptor Engineering. This review highlights recent advances in DNA‐based strategies for receptor engineering, including genetic approaches like domain fusion and site‐directed mutagenesis, as well as non‐genetic methods using functional nucleic acids, DNA nanostructures, and dynamic DNA reactions.
Hexin Nan +4 more
wiley +1 more source
Neural Plasticity, 2015 Age-related alterations in the expression of genes and corticostriatal synaptic plasticity were studied in the dorsal striatum of mice of four age groups from young (2-3 months old) to old (18–24 months of age) animals.
Aisa N. Chepkova +2 more
doaj +1 more source
Deleterious GRM1 mutations in schizophrenia.
PLoS ONE, 2012 We analysed a phenotypically well-characterised sample of 450 schziophrenia patients and 605 controls for rare non-synonymous single nucleotide polymorphisms (nsSNPs) in the GRM1 gene, their functional effects and family segregation.
Mohammed Akli Ayoub +9 more
doaj +1 more source
Enhancement of Short-Term Memory by Methyl-6-(Phenylethynyl)-Pyridine in the BTBR T+tf/J Mouse Model of Autism Spectrum Disorder [PDF]
Endocrinology and Metabolism, 2015 BackgroundAutism spectrum disorder (ASD) encompasses a range of disorders that are characterized by social and communication deficits and repetitive behaviors.
Haijie Yang, Sung-Oh Huh, Jae Seung Hong
doaj +1 more source
Fathoming the kynurenine pathway in migraine: why understanding the enzymatic cascades is still critically important [PDF]
, 2015 Kynurenine pathway, the quantitatively main branch of tryptophan metabolism, has been long been considered a source of nicotinamide adenine dinucleotide, although several of its products, the so-called kynurenines, are endowed with the capacity to ...
CURTO, MARTINA +4 more
core +1 more source
Structural Basis of GABAB Receptor Activation during Evolution
Advanced Science, EarlyView.This study explores the structural and functional mechanisms of the drosophila GABAB receptor, a key role in neurotransmission. Using cryo‐EM, the research reveals how the receptor's activation differs from its human counterpart, highlighting unique evolutionary features.
Guofei Hou +14 more
wiley +1 more source
Neurobiology of Stress, 2015 Glutamate, the main excitatory neurotransmitter in the central nervous system, exerts its effect through ionotropic and metabotropic receptors.
Rachel D. Moloney +5 more
doaj +1 more source