Results 61 to 70 of about 44,093 (262)

Different Activity Patterns in Retinal Ganglion Cells of TRPM1 and mGluR6 Knockout Mice

BioMed Research International, 2017
TRPM1, the first member of the melanoma-related transient receptor potential (TRPM) subfamily, is the visual transduction channel downstream of metabotropic glutamate receptor 6 (mGluR6) on retinal ON bipolar cells (BCs).
Haruki Takeuchi, Sho Horie, Satoru Moritoh, Hiroki Matsushima, Tesshu Hori, Y. Kimori, K. Kitano, Y. Tsubo, M. Tachibana, Chieko Koike   +9 more
semanticscholar   +1 more source

Neuro‐Cancer Interactions Shape Glioma Intratumoral Heterogeneity

Advanced Science, EarlyView.
This review proposes a conceptual framework for understanding glioma intratumoral heterogeneity shaped by neuro‐cancer interactions: functional patterns and transcriptional states. Functional patterns manifest as three major neural‐like adaptations with spatial and potentially hierarchical relationships, including neurogliomal synapses, glioma networks,
Tong Wu, Peiran Zhao, Zheng Chen, Tianlei Ying, Zhihong Nie, Wei Hua, Huiyan Li, Ying Mao, Wenbo Bu   +8 more
wiley   +1 more source

Negative allosteric modulation of the mGlu7 receptor reduces visceral hypersensitivity in a stress-sensitive rat strain

Neurobiology of Stress, 2015
Glutamate, the main excitatory neurotransmitter in the central nervous system, exerts its effect through ionotropic and metabotropic receptors.
Rachel D. Moloney, Anna V. Golubeva, Richard M. O'Connor, Mikhail Kalinichev, Timothy G. Dinan, John F. Cryan   +5 more
doaj   +1 more source

Analyses of GWAS and Sub‐Threshold Loci Lead to the Discovery of Dendrite Development and Morphology Dysfunction Underlying Schizophrenia Genetic Risk

Advanced Science, EarlyView.
A cost‐effective strategy is developed analyzing sub‐threshold GWAS loci (5 × 10−8 < P ≤ 10−6), identifying 180 risk loci and 304 high‐confidence genes through combined GWAS/subGWAS analysis. This approach reveals dendrite development and morphogenesis (DDM) as a novel SCZ pathway.
Rui Chen, Benjamin Siciliano, Quan Wang, Chongchong Xu, Qiang Wei, Hai Yang, James S Sutcliffe, Yi Jiang, Ying Ji, Chunyu Liu, Feixiong Cheng, Edwin H Cook, Nancy J Cox, Xue Zhong, Zhexing Wen, Bingshan Li   +15 more
wiley   +1 more source

Nicotine Use and Metabotropic Glutamate Receptor 5 in Individuals With Major Depressive and Posttraumatic Stress Disorders

Chronic Stress, 2023
Metabotropic glutamate receptor 5 (mGluR5) dysregulation has been implicated in the pathophysiology of many psychiatric disorders, as well as nicotine use and dependence.
Stephen R. Baldassarri, Ruth H. Asch, Ansel T. Hillmer, Robert H. Pietrzak, Nicole DellaGioia, Irina Esterlis, Margaret T. Davis   +6 more
doaj   +1 more source

Structural Basis of GABAB Receptor Activation during Evolution

Advanced Science, EarlyView.
This study explores the structural and functional mechanisms of the drosophila GABAB receptor, a key role in neurotransmission. Using cryo‐EM, the research reveals how the receptor's activation differs from its human counterpart, highlighting unique evolutionary features.
Guofei Hou, Shenglan Zhang, Cangsong Shen, Suyu Ji, Binqian Zou, Chanjuan Xu, Liang Li, Dandan Shen, Jiayin Liang, Haidi Chen, Philippe Rondard, Cheng Deng, Jun He, Yan Zhang, Jianfeng Liu   +14 more
wiley   +1 more source

Memantine Administration Enhances Glutamatergic and GABAergic Pathways in the Human Hippocampus of Alzheimer's Disease Patients [PDF]

Proteomics
ABSTRACT One of the traditional treatments in Alzheimer's disease (AD) is administration of memantine, the NMDA receptor antagonist. However, the molecular mechanism of the complex memantine action and the impact on the hippocampal proteome in humans is unknown.
Fabrik I, Kupcik R, Fabrikova D, Chvojkova M, Holubova K, Hakenova K, Horak M, Soukup J, Manethova M, Rusina R, Matej R, Ryska A, Soukup O.   +12 more
europepmc   +2 more sources

A Frank Assessment of SHANK: Impacts of Pathogenic Variations in SHANK3 on Preclinical Models of Phelan McDermid Syndrome

Autism Research, EarlyView.
ABSTRACT Although there are as many as 40 preclinical models of the neurodevelopmental disorder Phelan McDermid syndrome (PMS, or 22q13.3 deletion syndrome), detailed phenotypic analyses to compare the effects of different pathogenic variants and inform treatment design are lacking.
Vic Lin, Samantha M. Matta, Julia E. Dallman, Suzanne Hosie, Manon Moreau, Ashley E. Franks, Thomas Bourgeron, Elisa L. Hill‐Yardin   +7 more
wiley   +1 more source

Metabotropic glutamate receptor 5 knockout rescues obesity phenotype in a mouse model of Huntington’s disease

Scientific Reports, 2022
Obesity represents a global health problem and is characterized by metabolic dysfunctions and a low-grade chronic inflammatory state, which can increase the risk of comorbidities, such as atherosclerosis, diabetes and insulin resistance.
Rebeca P. M. Santos, Roberta Ribeiro, Talita H. Ferreira-Vieira, Rosaria D. Aires, Jessica M. de Souza, Bruna S. Oliveira, Anna Luiza D. Lima, Antônio Carlos P. de Oliveira, Helton J. Reis, Aline S. de Miranda, Erica M. L. Vieira, Fabiola M. Ribeiro, Luciene B. Vieira   +12 more
doaj   +1 more source

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source