JOR SPINE, Volume 8, Issue 3, September 2025.This study explores the role of Central Pattern Generators (CPGs) in locomotor recovery after spinal cord injury (SCI). It examines CPG organization, function, and modulation through amino acids, biogenic amines, and acetylcholine. Therapeutic strategies, including pharmacological, electrical, and optogenetic approaches, are reviewed, alongside current
Hao Su +4 more
wiley +1 more source
Targeting striatal metabotropic glutamate receptor type 5 in Parkinson's disease: bridging molecular studies and clinical trials [PDF]
, 2015 Metabotropic glutamate (mGlu) receptors are G protein-coupled receptors expressed primarily on neurons and glial cells modulating the effects of glutamatergic neurotransmission.
Arnau de Bolós, Josep M. +9 more
core +2 more sources
Recent Developments in the Optical Control of Adrenergic Signaling
Medicinal Research Reviews, Volume 45, Issue 5, Page 1307-1322, September 2025.ABSTRACT Adrenoceptors (ARs) play a vital role in various physiological processes and are key therapeutic targets. The advent of optical control techniques, including optogenetics and photopharmacology, offers the potential to modulate AR signaling with precise temporal and spatial resolution. In this review, we summarize the latest advancements in the
Shuang Shi +4 more
wiley +1 more source
Plasticity of GABA(B) receptor-mediated heterosynaptic interactions at mossy fibers after status epilepticus [PDF]
, 2003 Several neurotransmitters, including GABA acting at presynaptic GABAB receptors, modulate glutamate release at synapses between hippocampal mossy fibers and CA3 pyramidal neurons.
Bowery, N.G. +5 more
core
Addiction Biology, Volume 30, Issue 9, September 2025.ABSTRACT Chronic nicotine administration leads to neuroadaptations, an important process in nicotine and tobacco dependence for which treatments are limited. The cysteine pro‐drug, N‐acetyl‐cysteine (NAC), is a promising glutamatergic agent that has shown some clinical efficacy in reducing nicotine use in humans.
Kelsey Stoddart +5 more
wiley +1 more source
Angewandte Chemie International Edition, Volume 64, Issue 35, August 25, 2025.Controlling protein interactions is key to studying signaling. Antibody methods have limits, but chemical inducers of dimerization (CIDs) using HaloTags and SNAP‐Tags offer precise control. We present CIDs to covalently link heteromers with varied linkers and a FRET‐based sensor.
Michael Trumpp +8 more
wiley +1 more source
Broad spectrum proteomics analysis of the inferior colliculus following acute hydrogen sulfide exposure. [PDF]
, 2018 Acute exposure to high concentrations of H2S causes severe brain injury and long-term neurological disorders, but the mechanisms involved are not known.
Anantharam, Poojya +8 more
core
Selective Blockade of P/Q-Type Calcium Channels by the Metabotropic Glutamate Receptor Type 7 Involves a Phospholipase C Pathway in Neurons [PDF]
, 2000 Julie Perroy +5 more
openalex +1 more source
NO ASSOCIATION BETWEEN METABOTROPIC GLUTAMATE RECEPTORS 7 AND 8 (MGLUR7 AND MGLUR8) GENE POLYMORPHISMS AND WITHDRAWAL SEIZURES AND DELIRIUM TREMENS IN ALCOHOL-DEPENDENT INDIVIDUALS [PDF]
, 2002 U. W. Preuss
openalex +1 more source
Lack of the metabotropic glutamate receptor subtype 7 selectively modulates Theta rhythm and working memory [PDF]
, 2005 Christian Hölscher +5 more
openalex +1 more source