Frontiers in Neuroscience, 2023 The ventral tegmental area (VTA) mediates incentive salience and reward prediction error through dopamine (DA) neurons that are regulated by local VTA GABA neurons.
Isaac Ostlund +4 more
doaj +1 more source
Synthesis and evaluation of [11C]MMPIP as a potential radioligand for imaging of metabotropic glutamate 7 receptor in the brain [PDF]
EJNMMI Research, 2013 Abstract Background Metabotropic glutamate 7 (mGlu7) receptor is a crucial target protein for the development of pharmaceuticals against central nervous system disorders. In the present study, we synthesized [11C]MMPIP, a putative radioligand for mGlu7 (binding constant K B = 30 nM), and evaluated its ...
Kenji Furutsuka +10 more
openaire +3 more sources
A single psychotomimetic dose of ketamine decreases thalamocortical spindles and delta oscillations in the sedated rat [PDF]
arXiv, 2020 Background: In patients with psychotic disorders, sleep spindles are reduced, supporting the hypothesis that the thalamus and glutamate receptors play a crucial etio-pathophysiological role, whose underlying mechanisms remain unknown. We hypothesized that a reduced function of NMDA receptors is involved in the spindle deficit observed in schizophrenia.
arxiv
Algebraic study of receptor-ligand systems: a dose-response analysis [PDF]
arXiv, 2022 The study of a receptor-ligand system generally relies on the analysis of its dose-response (or concentration-effect) curve, which quantifies the relation between ligand concentration and the biological effect (or cellular response) induced when binding its specific cell surface receptor.
arxiv
Glia, EarlyView.ABSTRACT The mammalian suprachiasmatic nucleus (SCN) orchestrates daily (circadian) rhythms of physiology and behavior by broadcasting timing cues generated autonomously by its mutually reinforcing network of ~10,000 neurons and ~3000 astrocytes. Although astrocytic control of extracellular glutamate and GABA has been implicated in driving circadian ...
Andrew P. Patton +6 more
wiley +1 more source
Journal of Pharmacological Sciences, 2015 The blockade of metabotropic glutamate 5 (mGlu5) receptor has been reported to exert antidepressant effects in several animal models. We previously reported that both ketamine and an mGlu5 receptor antagonist exerted an effect in a novelty-suppressed ...
Kenichi Fukumoto, Shigeyuki Chaki
doaj +1 more source
Metabotropic Glutamate Receptor Activation in Cerebelar Purkinje Cells as Substrate for Adaptive Timing of the Classicaly Conditioned Eye Blink Response [PDF]
, 1995 To understand how the cerebellum adaptively times the classically conditioned nictitating membrane response (NMR), a model of the metabotropic glutamate receptor (mGluR) second messenger system in cerebellar Purkinje cells is constructed.
Bullock, Daniel +2 more
core +1 more source
Fathoming the kynurenine pathway in migraine: why understanding the enzymatic cascades is still critically important [PDF]
, 2015 Kynurenine pathway, the quantitatively main branch of tryptophan metabolism, has been long been considered a source of nicotinamide adenine dinucleotide, although several of its products, the so-called kynurenines, are endowed with the capacity to ...
CURTO, MARTINA +4 more
core +1 more source
The prion protein regulates glutamate-mediated Ca2+ entry and mitochondrial Ca2+ accumulation in neurons [PDF]
, 2017 The cellular prion protein (PrPC) whose conformational misfolding leads to the production of deadly prions, has a still-unclarified cellular function despite decades of intensive research.
Bertoli, Alessandro +8 more
core +1 more source
Navigating the treatment landscape of Alzheimer's disease: Current strategies and future directions
Ibrain, EarlyView.Alzheimer's disease treatment is evolving rapidly, with emerging strategies targeting multiple disease pathways. This graphical abstract highlights the shift from traditional therapies to innovative approaches that hold promise for improving outcomes.
Tapas Kumar Mohapatra +4 more
wiley +1 more source