Results 121 to 130 of about 51,002 (254)

Glutamatergic neurotransmission modulates hypoxia-induced hyperventilation but not anapyrexia

Brazilian Journal of Medical and Biological Research, 2004
The interaction between pulmonary ventilation (V E) and body temperature (Tb) is essential for O2 delivery to match metabolic rate under varying states of metabolic demand.
Paula P.M. de, Branco L.G.S.
doaj  

An expanding range of targets for kynurenine metabolites of tryptophan [PDF]

, 2013
The kynurenine pathway of tryptophan metabolism accounts for most of the tryptophan that is not committed to protein synthesis and includes compounds active in the nervous and immune systems.
Darlington, L. Gail, Stone, Trevor W., Stoy, Nicholas   +2 more
core   +1 more source

Peripheral Nerves in Cancer: Regulatory Roles and Therapeutic Strategies

MedComm, Volume 7, Issue 2, February 2026.
The interaction between cancer cells and peripheral nerves: (1) tumor cells could induce the growth of new neural axons and constructing a neural fiber network within the tumor tissue through secreting nerve growth factors; (2) nerve‐derived bioactive molecules can induce perineural invasion of tumor and regulate the malignant phenotype of tumor, such ...
Yan Fu, Zhi‐Shan Ge, Qing‐Yue Cao, Zi‐Han Li, An Zhang, Hai‐Dong Zhu, Gao‐Jun Teng   +6 more
wiley   +1 more source

Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome

Frontiers in Behavioral Neuroscience, 2015
Serotonin 5-HT7 receptors are expressed in the hippocampus and modulate the excitability of hippocampal neurons. We have previously shown that 5-HT7 receptors modulate glutamate-mediated hippocampal synaptic transmission and long-term synaptic plasticity.
Lara eCosta, Lara Maria Sardone, Enza eLacivita, Marcello eLeopoldo, Lucia eCiranna   +4 more
doaj   +1 more source

The Calcium‐Binding Protein S100A10 (p11) Is Required for Normal Motor Performance by Regulating Vesicle Dynamics at Excitatory Synapses

Acta Physiologica, Volume 242, Issue 2, February 2026.
ABSTRACT Aim Identifying interactors in sensorimotor processing and neurotransmission remains a current challenge for understanding neural information processing and brain function. Methods To evaluate the role of p11 in sensorimotor processing and excitatory synaptic neurotransmission, neuron‐specific lentivirus‐directed p11 silencing, small ...
Esther Vilches‐Herrando, Guillermo Rodríguez‐Bey, Rosendo G. Hernández, Ángela Gento‐Caro, Ángel M. Pastor, Antonio Campos‐Caro, David González‐Forero, Bernardo Moreno‐López   +7 more
wiley   +1 more source

Targeting metabotropic glutamate receptors for novel treatments of schizophrenia

Molecular Brain, 2017
Support for the N-methyl-d-aspartate receptor (NMDAR) hypofunction hypothesis of schizophrenia has led to increasing focus on restoring proper glutamatergic signaling as an approach for treatment of this devastating disease.
James Maksymetz, Sean P. Moran, P. Jeffrey Conn   +2 more
doaj   +1 more source

Ethanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings [PDF]

, 2016
Herein, we have reviewed the role of glutamate, the major excitatory neurotransmitter in the brain, in a number of neurochemical, -physiological, and -behavioral processes mediating the development of alcohol dependence.
Aal-Aaboda, Abe, Abulseoud, Ady, Agrawal, Alasmari, Alhaddad, Arriza, Babu, Bard, Bauer, Beattie, Begleiter, Bell, Bell, Bell, Bell, Bell, Bell, Besheer, Besheer, Besheer, Bischoff, Bockaert, Bondy, Bäckström, Béïque, Cannady, Cannella, Carlezon, Chandler, Chandler, Chefer, Chen, Chen, Cicero, Cloninger, Cohen-Gilbert, Comasco, Cotton, Cowen, Cozzoli, Cozzoli, Cozzoli, Crabbe, Danbolt, Das, Ding, Ding, Domart, Edenberg, Edenberg, Ehlers, El-Husseini, Ende, Enoch, Falco, Flatscher-Bader, Floyd, Fotuhi, Funke, Garbett, Garner, Gass, Gass, Goodwani, Gould, Goulding, Grace, Griffin, Hargreaves, Harris, Henley, Hermann, Hermens, Hodge, Isaac, Jaffrey, Jani, Jin, Joslyn, Kalivas, Kapasova, Kapoor, Karkkainen, Karpyak, Kimpel, Klugmann, Kohda, Konno, Koob, Kornau, Kranzler, Kryger, Krystal, Kuo, Kupila, Lallemand, Lappalainen, Laukkainen, Lester, Levey, Lin, Lin, Loh, Lominac, Long, Lum, Lüscher, Maday, Malenka, Malinow, Mardones, Matsumoto, McBride, McBride, McBride, McBride, McBride, McBride, McBride, McBride, McBride, McBride, McClintick, McCool, Meinhardt, Melendez, Mokdad, Monaghan, Morris, Nevo, Niciu, Obara, Olive, Orth, O’Connor, O’Connor, Patten, Petrakis, Petralia, Preuss, Qrunfleh, Quintero, Rani, Rao, Rao, Reed, Rehm, Rehm, Reich, Reimers, Reissner, Richter, Rietschel, Risher, Rodd, Rodd, Romano, Rothstein, Sala, Sari, Sari, Sari, Sari, Sari, Schnell, Schroeder, Schroeder, Schuckit, Schumann, Selim, Shaw, Sheng, Shigemoto, Shiraishi-Yamaguchi, Spanagel, Staples, Steketee, Swartzwelder, Swartzwelder, Swerdlow, Szumlinski, Szumlinski, Szumlinski, Szumlinski, Tamaru, Tanaka, Tao-Cheng, Tarazi, Terranova, Thoma, Tomita, Traynelis, Van Bockstaele, Vengeliene, Wadiche, Wang, Warburton, Ward, Watterson, Williams, Witzmann, Wong, Worley, Xia, Xiao, Yan, Zamora-Martinez, Zhao, Zhou, Zhou, Ziff   +212 more
core   +1 more source

Troriluzole attenuates opioid intake, reinforcing efficacy, seeking behaviours, physical dependence and antinociceptive tolerance in rats

British Journal of Pharmacology, Volume 183, Issue 3, Page 505-519, February 2026.
Background and Purpose Riluzole, approved for amyotrophic lateral sclerosis (ALS), has a glutamate‐modulating profile favourable for mitigating opioid addiction. It reduces neuronal glutamate release and enhances glutamate reuptake, offering advantages over agents that only increase glutamate reuptake.
Ewa Galaj, Saadet Inan, Guo‐Hua Bi, Sonita Wiah, George Adamson, Allen B. Reitz, Zheng‐Xiong Xi, Scott M. Rawls   +7 more
wiley   +1 more source

Noradrenaline Increases mEPSC Frequency in Pyramidal Cells in Layer II of Rat Barrel Cortex via Calcium Release From Presynaptic Stores

Frontiers in Cellular Neuroscience, 2018
Somatosensory cortex is innervated by afferents originating from the locus coeruleus which typically release noradrenaline. We tested if activation of presynaptic α1-adrenoceptors (AR) coupled to a Gq-mediated signaling cascade resulted in calcium (Ca2+)
Julian M. C. Choy, Fransiscus A. Agahari, Fransiscus A. Agahari, Li Li, Li Li, Christian Stricker, Christian Stricker   +6 more
doaj   +1 more source

Synthesis and characterization of 5-(2-fluoro-4-[ ¹¹ C]methoxyphenyl)-2,2-dimethyl-3,4-dihydro-2 H -pyrano[2,3- b ]pyridine-7-carboxamide as a PET imaging ligand for metabotropic glutamate receptor 2 [PDF]

, 2021
Gengyang Yuan, Maëva Dhaynaut, Yu Lan, Nicolas J. Guehl, Dalena Huynh, Suhasini M. Iyengar, Sepideh Afshar, Hao Wang, Sung‐Hyun Moon, Mary Jo Ondrechen, Changning Wang, Timothy M. Shoup, Georges El Fakhri, Marc D. Normandin, Anna‐Liisa Brownell   +14 more
openalex   +1 more source