Results 131 to 140 of about 64,471 (275)

Glutamatergic neurotransmission modulates hypoxia-induced hyperventilation but not anapyrexia

Brazilian Journal of Medical and Biological Research, 2004
The interaction between pulmonary ventilation (V E) and body temperature (Tb) is essential for O2 delivery to match metabolic rate under varying states of metabolic demand.
Paula P.M. de, Branco L.G.S.
doaj  

Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome

Frontiers in Behavioral Neuroscience, 2015
Serotonin 5-HT7 receptors are expressed in the hippocampus and modulate the excitability of hippocampal neurons. We have previously shown that 5-HT7 receptors modulate glutamate-mediated hippocampal synaptic transmission and long-term synaptic plasticity.
Lara eCosta, Lara Maria Sardone, Enza eLacivita, Marcello eLeopoldo, Lucia eCiranna   +4 more
doaj   +1 more source

[Characterization of metabotropic glutamate receptor 7 and 8 in rat superior cervical ganglion and their changes following chronic intermittent hypoxia]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao, 2023
Wei X, Li C, Zhao C, Zhao B, Liu Y.
europepmc   +1 more source

Drug-Induced Plasticity Contributing to Heightened Relapse Susceptibility: Neurochemical Changes and Augmented Reinstatement in High-Intake Rats [PDF]

, 2010
A key in understanding the neurobiology of addiction and developing effective pharmacotherapies is revealing drug-induced plasticity that results in heightened relapse susceptibility.
Baker, David A., Kau, Kristen S., Lobner, Doug, Madayag, Aric, Mantsch, John R., Wisniewski, Samantha   +5 more
core   +1 more source

Glutamatergic Plasticity in Medial Prefrontal Cortex and Ventral Tegmental Area Following Extended-Access Cocaine Self-Administration [PDF]

, 2011
Glutamate signaling in prefrontal cortex and ventral tegmental area plays an important role in the molecular and behavioral plasticity associated with addiction to drugs of abuse.
Ghasemzadeh, Behnam, Giles, Chad, Mantsch, John R., Purgianto, Anthony, Seubert, Chad, Vasudevan, Preethi   +5 more
core   +2 more sources

Light‐Activated Pharmacological Tools for Exploring the Cholinergic System

Medicinal Research Reviews, Volume 45, Issue 4, Page 1251-1274, July 2025.
ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni, Giulia Galli, Clelia Dallanoce, Marco De Amici, Pau Gorostiza, Carlo Matera   +5 more
wiley   +1 more source

Targeting metabotropic glutamate receptors for novel treatments of schizophrenia

Molecular Brain, 2017
Support for the N-methyl-d-aspartate receptor (NMDAR) hypofunction hypothesis of schizophrenia has led to increasing focus on restoring proper glutamatergic signaling as an approach for treatment of this devastating disease.
James Maksymetz, Sean P. Moran, P. Jeffrey Conn   +2 more
doaj   +1 more source

The mGlu7 receptor provides protective effects against epileptogenesis and epileptic seizures

Neurobiology of Disease, 2019
Finding new targets to control or reduce seizure activity is essential to improve the management of epileptic patients. We hypothesized that activation of the pre-synaptic and inhibitory metabotropic glutamate receptor type 7 (mGlu7) reduces spontaneous ...
Benoit Girard, Pola Tuduri, Maria Paula Moreno, Sophie Sakkaki, Cedric Barboux, Tristan Bouschet, Annie Varrault, Jihane Vitre, Isabelle McCort-Tranchepain, Julien Dairou, Francine Acher, Laurent Fagni, Nicola Marchi, Julie Perroy, Federica Bertaso   +14 more
doaj  

Regional brain mGlu5 receptor occupancy following single oral doses of mavoglurant as measured by [11C]-ABP688 PET imaging in healthy volunteers

NeuroImage, 2021
Mavoglurant binds to same allosteric site on metabotropic glutamate receptor 5 (mGluR5) as [11C]-ABP688, a radioligand. This open-label, single-center pilot study estimates extent of occupancy of mGluR5 receptors following single oral doses of ...
Johannes Streffer, Valerie Treyer, Alfred Buck, Simon M. Ametamey, Milen Blagoev, Ralph P Maguire, Aurélie Gautier, Yves P. Auberson, Mark E. Schmidt, Ivan-Toma Vranesic, Baltazar Gomez-Mancilla, Fabrizio Gasparini   +11 more
doaj  

Liquiritigenin‐Rich Hydroalcoholic Extract of Brazilian Red Propolis Reduces Dyskinesia Induced by 3,4‐ Dihydroxyphenylalanine in Hemiparkinsonian Rats

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 1, July 2025.
ABSTRACT The set‐up and progression of dyskinesia induced by 3,4‐dihydroxyphenylalanine (L‐DOPA) are strongly linked to oxidative stress and neuroinflammation. The aim of this work was to study and characterize the effects of the hydroalcoholic extract of Brazilian red propolis (HERP) on L‐DOPA–induced dyskinesia (LID) in hemiparkinsonian rats injected
Sheilla da Silva Barroso, Lorenna E. S. Lopes, Ana M. G. dos Santos, Reinaldo V. B. Neto, Bruno dos Santos Lima, Adriano A. de Souza Araújo, Juliana C. Cardoso, Patricia Severino, Eliana B. Souto, Margarete Z. Gomes   +9 more
wiley   +1 more source