British Journal of Pharmacology, EarlyView.G protein‐coupled receptors (GPCRs) play a crucial role in cell function by transducing signals from the extracellular environment to the inside of the cell. They mediate the effects of various stimuli, including hormones, neurotransmitters, ions, photons, food tastants and odorants, and are renowned drug targets.
Małgorzata M. Kogut‐Günthel +11 more
wiley +1 more source
Glutamatergic neurotransmission modulates hypoxia-induced hyperventilation but not anapyrexia
Brazilian Journal of Medical and Biological Research, 2004 The interaction between pulmonary ventilation (V E) and body temperature (Tb) is essential for O2 delivery to match metabolic rate under varying states of metabolic demand.
Paula P.M. de, Branco L.G.S.
doaj
Frontiers in Behavioral Neuroscience, 2015 Serotonin 5-HT7 receptors are expressed in the hippocampus and modulate the excitability of hippocampal neurons. We have previously shown that 5-HT7 receptors modulate glutamate-mediated hippocampal synaptic transmission and long-term synaptic plasticity.
Lara eCosta +4 more
doaj +1 more source
[Characterization of metabotropic glutamate receptor 7 and 8 in rat superior cervical ganglion and their changes following chronic intermittent hypoxia]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2023 Wei X, Li C, Zhao C, Zhao B, Liu Y.
europepmc +1 more source
A PI3K-mediated negative feedback regulates Drosophila motor neuron excitability [PDF]
, 2008 Negative feedback can act as a homeostatic mechanism to maintain neuronal activity at a particular specified value. At the Drosophila neuromuscular junction, a mutation in the type II metabotropic glutamate receptor gene (mGluRA) increased motor neuron ...
Curtis C. J. Lin +3 more
core +1 more source
Synthesis and biological evaluation of novel 2,3-dihydro-1H-1,5-benzodiazepin-2-ones; potential imaging agents of the metabotropic glutamate 2 receptor [PDF]
, 2013 A focused library of novel 2,3-dihydro-1H-1,5-benzodiazepin-2-ones containing sites for 11C-, 18F- and 123I-labelling have been prepared and evaluated against membrane expressing human recombinant metabotropic glutamate 2 receptor (mGluR2). The compounds
Barros +25 more
core +3 more sources
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Several G protein‐coupled receptors (GPCRs) are known to homodimerise. Dimeric GPCRs may have different properties from their monomers, but the molecular basis and functional significance of GPCR dimerisation remain largely unknown.
Satoshi Asano +6 more
wiley +1 more source
Targeting metabotropic glutamate receptors for novel treatments of schizophrenia
Molecular Brain, 2017 Support for the N-methyl-d-aspartate receptor (NMDAR) hypofunction hypothesis of schizophrenia has led to increasing focus on restoring proper glutamatergic signaling as an approach for treatment of this devastating disease.
James Maksymetz +2 more
doaj +1 more source
Pituitary Adenylate Cyclase-Activating Polypeptide Orchestrates Neuronal Regulation Of The Astrocytic Glutamate-Releasing Mechanism System x\u3csub\u3ec\u3c/sub\u3e\u3csup\u3e−\u3c/sup\u3e [PDF]
, 2016 Glutamate signaling is achieved by an elaborate network involving neurons and astrocytes. Hence, it is critical to better understand how neurons and astrocytes interact to coordinate the cellular regulation of glutamate signaling.
Albano, Rebecca +7 more
core +1 more source
TRPC1 mediates slow excitatory synaptic transmission in hippocampal oriens/alveus interneurons
Molecular Brain, 2020 Hippocampal GABAergic interneurons play key roles in regulating principal cell activity and plasticity. Interneurons located in stratum oriens/alveus (O/A INs) receive excitatory inputs from CA1 pyramidal cells and express a Hebbian form of long-term ...
André Kougioumoutzakis +4 more
doaj +1 more source