Results 161 to 170 of about 64,471 (275)

Repeated \u3cem\u3eN\u3c/em\u3e-Acetylcysteine Administration Alters Plasticity-Dependent Effects of Cocaine [PDF]

, 2007
Cocaine produces a persistent reduction in cystine–glutamate exchange via system xc− in the nucleus accumbens that may contribute to pathological glutamate signaling linked to addiction.
Abdulhameed, Omer, Baker, David A., Grier, Mark D., Hearing, Matthew, Kau, Kristen S., Lobner, Doug, Madayag, Aric, Mantsch, John R.   +7 more
core   +1 more source

Delineating the stepwise millisecond allosteric activation mechanism of the class C GPCR dimer mGlu5

Nature Communications
Two-thirds of signaling hormones and one-third of approved drugs exert their effects by binding and modulating the G protein-coupled receptors (GPCRs) activation.
Mingyu Li, Xiaobing Lan, Xinchao Shi, Chunhao Zhu, Xun Lu, Jun Pu, Shaoyong Lu, Jian Zhang   +7 more
doaj   +1 more source

7-(Hydroxyimino)cyclopropa[b]chromen-la-carboxylates, novel antagonists for group I metabotropic glutamate receptor

, 1998
Yoshiko Horikawa, Shigeki Tamura, Hirokazu Annoura, Toshio Tatsuoka, Norio Inomata, Tomochika Ohno   +5 more
openalex   +1 more source

Stimulation of Metabotropic Glutamate (mGlu) 2 Receptor and Blockade of mGlu1 Receptor Improve Social Memory Impairment Elicited by MK-801 in Rats

Journal of Pharmacological Sciences, 2013
.: Glutamatergic dysfunction has been implicated in psychiatric disorders such as schizophrenia. Both the stimulation of the metabotropic glutamate (mGlu) 2/3 receptor and the blockade of the mGlu1 receptor have been shown to be effective in a number of ...
Hirohiko Hikichi, Ayaka Kaku, Jun-ichi Karasawa, Shigeyuki Chaki   +3 more
doaj  

The C-terminal Tail of the Metabotropic Glutamate Receptor Subtype 7 Is Necessary but Not Sufficient for Cell Surface Delivery and Polarized Targeting in Neurons and Epithelia [PDF]

, 2001
J. Brian McCarthy, Seung T. Lim, N. Barry Elkind, James S. Trimmer, Robert M. Duvoisin, Enrique Rodriguez‐Boulan, Michael J. Caplan   +6 more
openalex   +1 more source

Genome-Wide Detection of Leukemia Biomarkers from lincRNA–Protein-Coding Gene Interaction Networks in the Three-Dimensional Chromatin Structure

Current Issues in Molecular Biology
The human genome is widely transcribed, with part of these transcribed regions producing stably expressed protein-coding or non-coding RNAs. Long intergenic non-coding RNAs (lincRNAs) are significantly differentially expressed in various cell lines and ...
Yue Hou, Wei Ning, Muren Huhe, Chuanjun Shu   +3 more
doaj   +1 more source

Co-expression of Metabotropic Glutamate Receptor 7 and N-type Ca2+ Channels in Single Cerebrocortical Nerve Terminals of Adult Rats [PDF]

, 2003
Carmelo Millán, Enrique Castro, Magdalena Torres, Ryuichi Shigemoto, José Sánchez‐Prieto   +4 more
openalex   +1 more source

Test-retest properties of [11C]PXT012253 as a positron emission tomography (PET) radiotracer in healthy human brain: PET imaging of mGlu4

EJNMMI Research
Background The metabotropic glutamate receptor 4 (mGlu4) has been proposed as a target for Parkinson’s disease to measure levodopa-induced dyskinesia. [11C]PXT012253 is a PET radioligand for mGlu4 (3.4 nM), previously characterized in non-human primates.
Per Stenkrona, Ryosuke Arakawa, Jiamei Guo, Benny Bang-Andersen, Sangram Nag, Mohammad Mahdi Moein, Zhisheng Jia, Zsolt Cselenyi, Christer Halldin, Andrea Varrone   +9 more
doaj   +1 more source

Involvement of subtype 1 metabotropic glutamate receptors in apoptosis and caspase-7 over-expression in spinal cord of neuropathic rats [PDF]

, 2008
Dario Siniscalco, Catia Giordano, Carlo Fuccio, Livio Luongo, Franca Ferraraccio, Francesca Rossi, Vito de Novellis, Kevin A. Roth, Sabatino Maione   +8 more
openalex   +1 more source

Functional monoclonal antibody acts as a biased agonist by inducing internalization of metabotropic glutamate receptor 7 [PDF]

, 2012
Christoph Ullmer, Sannah Zoffmann, Bernd Bohrmann, Hugues Matile, Lothar Lindemann, PJ Flor, Pari Malherbe   +6 more
openalex   +1 more source