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Metabotropic Glutamate Receptor Subtype 7 Is Essential for Ejaculation
Molecular Neurobiology, 2020Metabotropic glutamate receptor subtype 7 (mGluR7) is a member of the group III mGluRs, which are negatively coupled to adenylate cyclase via Gi/Go proteins and localized to presynaptic active zones of the mammalian central nervous system (CNS). To elucidate the mechanism of impaired reproductivity of mGluR7 knockout (KO) mice, we investigated sexual ...
Miwako Masugi-Tokita +7 more
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Metabotropic glutamate receptor 7: at the interface of cognition and emotion.
European Journal of Pharmacology, 2010Understanding the complex interaction between stress and genetics that leads to the manifestation of disorders such as depression, anxiety, and cognitive dysfunction is one of the key areas of research in modern neuroscience. Growing evidence suggests that the glutamatergic system may be a relevant therapeutic target for such disorders.
R. M. O’Connor +3 more
semanticscholar +3 more sources
Immunolocalization of metabotropic glutamate receptor 7 in the rat olfactory bulb
The Journal of Comparative Neurology, 1997Metabotropic glutamate receptors (mGluRs) constitute a large family of G-protein-coupled receptors that are subdivided into three groups based on sequence similarity, pharmacological profiles, and coupling to second messengers. Although mRNAs for seven of the eight mGluRs are expressed in the olfactory system, the localization and function of specific ...
J. Kinzie +4 more
semanticscholar +4 more sources
Neuropharmacology, 2016 The co-existence of presynaptic G protein coupled receptors, GPCRs, has received little attention, despite the fact that interplay between the signaling pathways activated by such receptors may affect the neurotransmitter release. Using immunocytochemistry and immuhistochemistry we show that mGlu7 and β-adrenergic receptors are co-expressed in a sub ...
J. J. Ferrero +4 more
semanticscholar +4 more sources
The Metabotropic Glutamate Receptor 7 Allosteric Modulator AMN082: A Monoaminergic Agent in Disguise? [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2011 Metabotropic glutamate receptor 7 (mGluR7) remains the most elusive of the eight known mGluRs primarily because of the limited availability of tool compounds to interrogate its potential therapeutic utility. The discovery of N,N'-dibenzhydrylethane-1,2-diamine dihydrochloride (AMN082) as the first orally active, brain-penetrable, mGluR7-selective ...
Stacey J. Sukoff Rizzo +23 more
semanticscholar +3 more sources
Expression and purification of metabotropic glutamate receptor 7 peptides
Protein Expression and Purification, 2010Metabotropic glutamate receptors (mGluRs) influence a variety of second-messenger systems and ion channels. The C-terminal region of group III mGluRs interacts with the Ca(2+)-binding protein calmodulin (CaM). We intend to study the interaction between Ca(2+)/CaM and the CaM-binding motifs within mGluR(7), which is a group III mGluR.
Noriyoshi Isozumi, Shinya Ohki
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Isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists
Bioorganic & Medicinal Chemistry Letters, 2010AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Hisashi Ohta +5 more
openaire +4 more sources