Results 181 to 190 of about 64,659 (227)

Role of metabotropic glutamate receptor 7 in autism spectrum disorders: a pilot study.

Life Sciences, 2013
The presence of genetic variants for autism spectrum disorders (ASDs) was investigated for the metabotropic glutamate receptor 7 (GRM7) gene in a case-control study.Employing Affymetrix SNP microarrays, 297 single nucleotide polymorphisms (SNPs) covering the GRM7 gene were selected and analyzed in ASD patients (n=22), non-ASD patients [n=14, including ...
You Yang, Chun-Hern Pan
semanticscholar   +4 more sources

Localization of metabotropic glutamate receptor 7 mRNA and mGluR7a protein in the rat basal ganglia

The Journal of Comparative Neurology, 1999
Metabotropic glutamate receptors (mGluRs) coupled to G-proteins have important roles in the regulation of basal ganglia function. We have examined the localization of the mGluR7 mRNA and mGluR7a protein in the basal ganglia of the rat. Strong mGluR7 hybridization signals are found in cerebral cortex and striatum, but much less intense signals are ...
C. Kosinski, Stefania Risso Bradley, P. Conn, A. Levey, G. Landwehrmeyer, J. Penney, A. Young, D. Standaert   +7 more
semanticscholar   +4 more sources

Computationally Guided Identification of Allosteric Agonists of the Metabotropic Glutamate 7 Receptor

ACS Chemical Neuroscience, 2018
The metabotropic glutamate 7 (mGlu7) receptor belongs to the group III of mGlu receptors. Since the mGlu7 receptor can control excitatory neurotransmission in the hippocampus and cortex, modulation of the receptor may have therapeutic benefit in several CNS diseases.
Jose María Cid, Hilde Lavreysen, Gary Tresadern, Laura Pérez-Benito, Fulgencio Tovar, Alberto Fontana, Andrés A. Trabanco   +6 more
openaire   +3 more sources

Type-7 metabotropic glutamate receptors negatively regulate α1-adrenergic receptor signalling

Neuropharmacology, 2017
We studied the interaction between mGlu7 and α1-adrenergic receptors in heterologous expression systems, brain slices, and living animals. L-2-Amino-4-phosphonobutanoate (L-AP4), and l-serine-O-phosphate (L-SOP), which activate group III mGlu receptors, restrained the stimulation of polyphosphoinositide (PI) hydrolysis induced by the α1-adrenergic ...
Iacovelli, Luisa, Di Menna, Luisa, Peterlik, Daniel, Stangl, Christina, Orlando, Rosamaria, Molinaro, Gemma, DE BLASI, Antonio, Bruno, Valeria Maria Gloria, Battaglia, Giuseppe, Flor, Peter J., Uschold Schmidt, Nicole, Nicoletti, Ferdinando   +11 more
openaire   +4 more sources

In Vitro Pharmacological Characterization of Novel Isoxazolopyridone Derivatives as Allosteric Metabotropic Glutamate Receptor 7 Antagonists

The Journal of Pharmacology and Experimental Therapeutics, 2007
Novel isoxazolopyridone derivatives that are metabotropic glutamate receptor (mGluR) 7 antagonists were discovered and pharmacologically characterized. 5-Methyl-3,6-diphenylisoxazolo[4,5-c]pyridin-4(5H)-one (MDIP) was identified by random screening, and 6-(4-methoxyphenyl)-5-methyl-3-pyridin-4-ylisoxazolo[4,5-c]pyridin-4(5H)-one (MMPIP) was produced by
G. Suzuki, Naohiro Tsukamoto, H. Fushiki, A. Kawagishi, Masayuki Nakamura, H. Kurihara, M. Mitsuya, M. Ohkubo, H. Ohta   +8 more
semanticscholar   +4 more sources

Amygdaloid metabotropic glutamate receptor subtype 7 is involved in the acquisition of conditioned fear

NeuroReport, 2008
The metabotropic glutamate receptor subtype 7 (mGluR7) is presynaptically located and modulates transmitter release. An earlier study from our group demonstrated that systemic administration of N,N'-dibenzyhydryl-ethane-1,2-diamine dihydrochloride (AMN082), a selective allosteric mGluR7 agonist, attenuates the acquisition of conditioned fear measured ...
Markus Fendt, Peter J. Flor, Stephanie Siegl   +2 more
openaire   +3 more sources

Distribution of metabotropic glutamate receptor 7 messenger RNA in the developing and adult rat brain

Neuroscience, 1995
The large number of metabotropic glutamate receptor subtypes suggests diverse roles in brain function, although specific distribution patterns can give clues to subtype-specific functions [Hayashi Y. et al. (1993) Nature 366, 687-690; Nakajima Y. et al. (1993) J. biol. Chem. 268, 11868-11873; Nomura A. et al. (1994) Cell 77, 361-369; Ohishi H.
J. Kinzie, J. Saugstad, Gary L. Westbrook, Thomas P. Segerson   +3 more
semanticscholar   +4 more sources

Metabotropic Glutamate 7 Receptor Subtype Modulates Motor Symptoms in Rodent Models of Parkinson's Disease [PDF]

The Journal of Pharmacology and Experimental Therapeutics, 2010
Metabotropic glutamate (mGlu) receptors modulate synaptic transmission in the central nervous system and represent promising therapeutic targets for symptomatic treatment of Parkinson's disease (PD). Among the eight mGlu receptor subtypes, mGlu7 receptor is prominently expressed in the basal ganglia, but its role in restoring motor function in animal ...
Greco, B., Lopez, S., Putten, H., Flor, P. J., Amalric, Marianne   +4 more
openaire   +3 more sources

Human metabotropic glutamate receptor type 7: Molecular cloning and mRNA distribution in the CNS

Molecular Brain Research, 1996
Human metabotropic glutamate receptor type 7 (mGluR7) cDNA clones were isolated from a medulla cDNA library. The sequence, which includes a polymorphism, has 92% DNA sequence identity with rat mGluR7 and the predicted protein sequence has 99% identity.
Piers C. Emson, K.A. Harrington, A. J. Makoff, Charles Pilling   +3 more
openaire   +3 more sources

Metabotropic glutamate 7 receptor agonist AMN082 inhibits glutamate release in rat cerebral cortex nerve terminal

European Journal of Pharmacology, 2018
AMN082 is a selective metabotropic glutamate mGlu7 receptor agonist reported to exhibit antidepressant activity. Considering that excessive glutamate release is involved in the pathogenesis of depression, the effect of N,N'-dibenzyhydryl-ethane-1,2-diamine dihydrochloride (AMN082) on glutamate release in rat cerebrocortical nerve terminals and the ...
Shu Kuei Huang, Che Chuan Wang, Su-Jane Wang, Su-Jane Wang, Jinn Rung Kuo   +4 more
openaire   +3 more sources