Results 191 to 200 of about 64,659 (227)

Agonists and Antagonists for Group III Metabotropic Glutamate Receptors 6, 7 and 8

Current Topics in Medicinal Chemistry, 2005
Metabotropic glutamate receptors (mGluRs) have been implicated in a variety of neurological and psychiatric disorders. This article describes recent progress in the development of agonists and antagonists for mGluR 6, 7, and 8. All of them are conformationally constrained or substituted amino acids, and they act at N-terminal extracellular glutamate ...
openaire   +2 more sources

Comparison of hippocampal metabotropic glutamate receptor 7 (mGlu7) mRNA levels in two animal models of depression

Neuroscience Letters, 2010
There is increasing evidence to suggest that metabotropic glutamate (mGlu) receptors including mGlu(7) receptor are important in the pathophysiology of stress-related psychiatric disorders such as anxiety and major depression. mGlu(7) receptor is highly expressed in the hippocampus, a key region involved in the modulation of depression-related ...
John F. Cryan, Cliona M. O'Mahony, Timothy G. Dinan, Javier A. Bravo   +3 more
openaire   +3 more sources

Dissociation of protein kinase-mediated regulation of metabotropic glutamate receptor 7 (mGluR7) interactions with calmodulin and regulation of mGluR7 function.

Molecular Pharmacology, 2002
Presynaptic metabotropic glutamate receptors (mGluRs) often act as feedback inhibitors of synaptic transmission and serve important roles in defining the activity of glutamatergic synapses.
S. Sorensen, T. Macek, Z. Cai, J. Saugstad, P. Conn   +4 more
semanticscholar   +1 more source

Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists

Bioorganic & Medicinal Chemistry Letters, 2007
Rational replacement of the alkyne linker of mGluR5 antagonist MPEP gave 7-arylquinolines. SAR optimization gave an orally active compound with high affinity for the MPEP binding site.
Kristen K. Gillespie, John A. Wendt, Jared B.J. Milbank, Corinne E. Augelli-Szafran, Susan M. Lotarski, Annette T. Sakkab-Tan, Jack J. Kinsora, Zhuang Nian, Mickelson John, Korana Stakich, Kristin Knapp Lin, Roy D. Schwarz, Jennifer K. Hoffman, Wing Lam, Abdul E. Mutlib, Koji Yamagata, Christopher S. Knauer, Paul Galatsis, John W. Thomas   +18 more
openaire   +3 more sources

Selective activation of metabotropic glutamate receptor 7 blocks paclitaxel-induced acute neuropathic pain and suppresses spinal glial reactivity in rats

Psychopharmacology, 2020
Jiali Wang, Changyu Jiang, Xiyuan Ba, Shimin Yang, Jiaman Wu, Zelin Huang, Guangyi Jin, Y. Hao   +7 more
semanticscholar   +1 more source

Metabotropic Glutamate Receptor 7 (mGluR7) as a Target for Modulating Pain-evoked Activities of Neurons in the Hippocampal CA3 Region of Rats.

CNS and Neurological Disorders - Drug Targets, 2017
Xinya Wei, Dong-xiao Yang, Tie-feng Shi, Jianing Wang, Yunling Deng, X. Qiao, Chun-xiao Yang, Man-ying Xu   +7 more
semanticscholar   +1 more source

A single nucleotide polymorphism in the metabotropic glutamate receptor 7 gene is associated with multiple sclerosis in Iranian population.

Multiple Sclerosis and Related Disorders, 2019
M. Mazdeh, R. Noroozi, A. Komaki, Iman Azari, S. Ghafouri-Fard, M. Taheri   +5 more
semanticscholar   +1 more source

The influence of AMN082, metabotropic glutamate receptor 7 (mGlu7) allosteric agonist on the acute and chronic antinociceptive effects of morphine in the tail-immersion test in mice: Comparison with mGlu5 and mGlu2/3 ligands

Physiology and Behavior, 2018
K. Gawel, Malgorzata Jenda-Wojtanowska, E. Gibuła-Bruzda, Ewa Kędzierska, Joanna Filarowska, M. Marszałek-Grabska, K. Wojtanowski, L. Komsta, Sylwia Talarek, J. Kotlinska   +9 more
semanticscholar   +1 more source

Rare de novo deletion of metabotropic glutamate receptor 7 (GRM7) gene in a patient with autism spectrum disorder

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2015
Yi Liu, Yanqing Zhang, Dongmei Zhao, Rui Dong, Xiaomeng Yang, K. Tammimies, M. Uddin, S. Scherer, Z. Gai   +8 more
semanticscholar   +1 more source

Chimeric antigen receptor T‐cell therapy in multiple myeloma: A comprehensive review of current data and implications for clinical practice

Ca-A Cancer Journal for Clinicians, 2023

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