Results 221 to 230 of about 64,471 (275)
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Metabotropic glutamate receptor 7: at the interface of cognition and emotion.
European Journal of Pharmacology, 2010Understanding the complex interaction between stress and genetics that leads to the manifestation of disorders such as depression, anxiety, and cognitive dysfunction is one of the key areas of research in modern neuroscience. Growing evidence suggests that the glutamatergic system may be a relevant therapeutic target for such disorders.
R. M. O’Connor +3 more
semanticscholar +3 more sources
Neuropharmacology, 2016 The co-existence of presynaptic G protein coupled receptors, GPCRs, has received little attention, despite the fact that interplay between the signaling pathways activated by such receptors may affect the neurotransmitter release. Using immunocytochemistry and immuhistochemistry we show that mGlu7 and β-adrenergic receptors are co-expressed in a sub ...
J. J. Ferrero +4 more
semanticscholar +4 more sources
Immunolocalization of metabotropic glutamate receptor 7 in the rat olfactory bulb
The Journal of Comparative Neurology, 1997Metabotropic glutamate receptors (mGluRs) constitute a large family of G-protein-coupled receptors that are subdivided into three groups based on sequence similarity, pharmacological profiles, and coupling to second messengers. Although mRNAs for seven of the eight mGluRs are expressed in the olfactory system, the localization and function of specific ...
J. Kinzie +4 more
semanticscholar +4 more sources
The Metabotropic Glutamate Receptor 7 Allosteric Modulator AMN082: A Monoaminergic Agent in Disguise? [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2011 Metabotropic glutamate receptor 7 (mGluR7) remains the most elusive of the eight known mGluRs primarily because of the limited availability of tool compounds to interrogate its potential therapeutic utility. The discovery of N,N'-dibenzhydrylethane-1,2-diamine dihydrochloride (AMN082) as the first orally active, brain-penetrable, mGluR7-selective ...
Stacey J Sukoff Rizzo +23 more
semanticscholar +3 more sources
Expression and purification of metabotropic glutamate receptor 7 peptides
Protein Expression and Purification, 2010Metabotropic glutamate receptors (mGluRs) influence a variety of second-messenger systems and ion channels. The C-terminal region of group III mGluRs interacts with the Ca(2+)-binding protein calmodulin (CaM). We intend to study the interaction between Ca(2+)/CaM and the CaM-binding motifs within mGluR(7), which is a group III mGluR.
Noriyoshi Isozumi, Shinya Ohki
openaire +3 more sources
Role of metabotropic glutamate receptor 7 in autism spectrum disorders: a pilot study.
Life Sciences, 2013The presence of genetic variants for autism spectrum disorders (ASDs) was investigated for the metabotropic glutamate receptor 7 (GRM7) gene in a case-control study.Employing Affymetrix SNP microarrays, 297 single nucleotide polymorphisms (SNPs) covering the GRM7 gene were selected and analyzed in ASD patients (n=22), non-ASD patients [n=14, including ...
You Yang, Chun-Hern Pan
semanticscholar +4 more sources
Isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists
Bioorganic & Medicinal Chemistry Letters, 2010AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Hisashi Ohta +5 more
openaire +4 more sources
CNS and Neurological Disorders - Drug Targets, 2017
BACKGROUND Metabotropic glutamate could contribute to the development of neuropathic pain-related behaviors. Previously, we have confirmed that the glutamic acid and dizocilpine maleate in the hippocampal CA3 region are involved in the modulation of ...
Xinya Wei +7 more
semanticscholar +1 more source
BACKGROUND Metabotropic glutamate could contribute to the development of neuropathic pain-related behaviors. Previously, we have confirmed that the glutamic acid and dizocilpine maleate in the hippocampal CA3 region are involved in the modulation of ...
Xinya Wei +7 more
semanticscholar +1 more source
Localization of metabotropic glutamate receptor 7 mRNA and mGluR7a protein in the rat basal ganglia
The Journal of Comparative Neurology, 1999Metabotropic glutamate receptors (mGluRs) coupled to G-proteins have important roles in the regulation of basal ganglia function. We have examined the localization of the mGluR7 mRNA and mGluR7a protein in the basal ganglia of the rat. Strong mGluR7 hybridization signals are found in cerebral cortex and striatum, but much less intense signals are ...
C. Kosinski +7 more
semanticscholar +4 more sources
Molecular Pharmacology, 2023
Metabotropic glutamate receptor 7 (mGlu7) is a G protein coupled receptor that has demonstrated promise as a therapeutic target across a number of neurologic and psychiatric diseases. Compounds that modulate the activity of mGlu7, such as positive and negative allosteric modulators, may represent new therapeutic strategies to modulate receptor activity.
Xia Lei +3 more
openaire +2 more sources
Metabotropic glutamate receptor 7 (mGlu7) is a G protein coupled receptor that has demonstrated promise as a therapeutic target across a number of neurologic and psychiatric diseases. Compounds that modulate the activity of mGlu7, such as positive and negative allosteric modulators, may represent new therapeutic strategies to modulate receptor activity.
Xia Lei +3 more
openaire +2 more sources