The role of metabotropic glutamate receptor 7 (mGluR7) in drug dependence [PDF]
Current Issues of Pharmacy and Medical Sciences, 2012 The successful pharmacotherapy for drug addiction is a challenge for pharmacology in XXI century. We still do not have any registered medication for cocaine by FDA, alcohol therapies are not enough successful. High hopes concern metabotropic glutamate 7 receptor as a target for pharmacotherapy development of drug dependence.
Małgorzata Jenda +2 more
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Metabotropic glutamate 7 (mGlu7) receptor: A target for medication development for the treatment of cocaine dependence [PDF]
Neuropharmacology, 2012 Brain glutamate has been shown to play an important role in reinstatement to drug seeking, a behavior considered to be of relevance to relapse to drug taking in humans. Therefore, glutamate receptors, in particular metabotropic glutamate (mGlu) receptors, have become important targets for medication development for the treatment of drug dependence.
Xia Li, Zheng‐Xiong Xi, Athina Markou
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Glutamate receptor metabotropic 7 is cis-regulated in the mouse brain and modulates alcohol drinking
Genomics, 2007 Alcoholism is a heritable disease that afflicts about 8% of the adult population. Its development and symptoms, such as craving, loss of control, physical dependence, and tolerance, have been linked to changes in mesolimbic, mesocortical neurotransmitter systems utilizing biogenic amines, GABA, and glutamate.
Csaba Vadász +7 more
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Effects of lead exposure on hippocampal metabotropic glutamate receptor subtype 3 and 7 in developmental rats [PDF]
Journal of Negative Results in BioMedicine, 2009 A complete explanation of the mechanisms by which Pb2+ exerts toxic effects on developmental central nervous system remains unknown. Glutamate is critical to the developing brain through various subtypes of ionotropic or metabotropic glutamate receptors (mGluRs).
Jian Xu +5 more
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Emotional Impairment and Persistent Upregulation of mGlu5 Receptor following Morphine Abstinence: Implications of an mGlu5-MOPr Interaction. [PDF]
, 2016 BACKGROUND: A difficult problem in treating opioid addicts is the maintenance of a drug-free state because of the negative emotional symptoms associated with withdrawal, which may trigger relapse.
Bailey, A +8 more
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mGlu1 Receptors Monopolize the Synaptic Control of Cerebellar Purkinje Cells by Epigenetically Down-Regulating mGlu5 Receptors [PDF]
, 2018 In cerebellar Purkinje cells (PCs) type-1 metabotropic glutamate (mGlu1) receptors play a key role in motor learning and drive the refinement of synaptic innervation during postnatal development.
Atsu Aiba +16 more
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mGluR5 antagonism inhibits cocaine reinforcement and relapse by elevation of extracellular glutamate in the nucleus accumbens via a CB1 receptor mechanism. [PDF]
, 2018 Metabotropic glutamate receptor 5 (mGluR5) antagonism inhibits cocaine self-administration and reinstatement of drug-seeking behavior. However, the cellular and molecular mechanisms underlying this action are poorly understood.
Bi, Guo-Hua +9 more
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Metabotropic glutamate 2/3 receptors and epigenetic modifications in psychotic disorders: a review [PDF]
, 2016 Schizophrenia and Bipolar Disorder are chronic psychiatric disorders, both considered as "major psychosis"; they are thought to share some pathogenetic factors involving a dysfunctional gene x environment interaction.
Grayson, Danis R +4 more
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Analysis of metabotropic glutamate receptor 7 as a potential substrate for SUMOylation
Neuroscience Letters, 2011 Group III metabotropic glutamate receptors (mGluRs) undergo post-translational modification by SUMO in in vitro assays but the SUMOylation of full-length mGluRs in mammalian cells has not been reported. Here we investigated SUMOylation of mGluR7 in HEK293 cells and primary cortical neurons in an attempt to confirm SUMOylation and define physiological ...
Wilkinson, KA, Henley, JM
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Targeting mGlu5 metabotropic glutamate receptors in the treatment of cognitive dysfunction in a mouse model of phenylketonuria [PDF]
, 2018 We studied group-I metabotropic glutamate (mGlu) receptors in Pah(enu2) (ENU2) mice, which mimic the genetics and neurobiology of human phenylketonuria (PKU), a metabolic disorder characterized, if untreated, by autism, and intellectual disability (ID ...
Battaglia, Giuseppe +12 more
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