Metabotropic Glutamate Receptor 7 Modulates the Rewarding Effects of Cocaine in Rats: Involvement of a Ventral Pallidal GABAergic Mechanism [PDF]
Neuropsychopharmacology, 2009 Xia Li +5 more
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The role of metabotropic glutamate receptor 7 (mGluR7) in drug dependence [PDF]
Current Issues of Pharmacy and Medical Sciences, 2012 The successful pharmacotherapy for drug addiction is a challenge for pharmacology in XXI century. We still do not have any registered medication for cocaine by FDA, alcohol therapies are not enough successful. High hopes concern metabotropic glutamate 7 receptor as a target for pharmacotherapy development of drug dependence.
Małgorzata Jenda +2 more
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Metabotropic glutamate 7 (mGlu7) receptor: A target for medication development for the treatment of cocaine dependence [PDF]
Neuropharmacology, 2012 Brain glutamate has been shown to play an important role in reinstatement to drug seeking, a behavior considered to be of relevance to relapse to drug taking in humans. Therefore, glutamate receptors, in particular metabotropic glutamate (mGlu) receptors, have become important targets for medication development for the treatment of drug dependence.
Xia Li, Zheng‐Xiong Xi, Athina Markou
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European Psychiatry, 2023 Introduction Schizophrenia is a neuropsychiatric disorder characterised by positive, negative and cognitive behavioral symptoms. Despite years of research, the need for suitable therapy remains elusive.
R. O. Folarin, O. Owoeye, A. Malomo
doaj +1 more source
Astrocyte activation in the anterior cingulate cortex and altered glutamatergic gene expression during paclitaxel-induced neuropathic pain in mice [PDF]
PeerJ, 2015 Spinal astrocyte activation contributes to the pathogenesis of paclitaxel-induced neuropathic pain (PINP) in animal models. We examined glial fibrillary acidic protein (GFAP; an astrocyte marker) immunoreactivity and gene expression of GFAP, glutamate ...
Willias Masocha
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Apo-state structure of the metabotropic glutamate receptor 5 transmembrane domain obtained using a photoswitchable ligand. [PDF]
Protein SciAbstract Metabotropic glutamate receptor 5 (mGlu5) is implicated in various neurodegenerative disorders, making it an attractive drug target. Although several ligand‐bound crystal structures of mGlu5 exist, their apo‐state crystal structure remains unknown.
Kondo Y +15 more
europepmc +2 more sources
Glutamate receptor metabotropic 7 is cis-regulated in the mouse brain and modulates alcohol drinking
Genomics, 2007 Alcoholism is a heritable disease that afflicts about 8% of the adult population. Its development and symptoms, such as craving, loss of control, physical dependence, and tolerance, have been linked to changes in mesolimbic, mesocortical neurotransmitter systems utilizing biogenic amines, GABA, and glutamate.
Csaba Vadász +7 more
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Overexpression of mGluR7 in the Prefrontal Cortex Attenuates Autistic Behaviors in Mice
Frontiers in Cellular Neuroscience, 2021 Autism spectrum disorder (ASD) is associated with a range of abnormalities pertaining to socialization, communication, repetitive behaviors, and restricted interests. Owing to its complexity, the etiology of ASD remains incompletely understood.
Xiaona Wang +8 more
doaj +1 more source
Effects of lead exposure on hippocampal metabotropic glutamate receptor subtype 3 and 7 in developmental rats [PDF]
Journal of Negative Results in BioMedicine, 2009 A complete explanation of the mechanisms by which Pb2+ exerts toxic effects on developmental central nervous system remains unknown. Glutamate is critical to the developing brain through various subtypes of ionotropic or metabotropic glutamate receptors (mGluRs).
Jian Xu +5 more
openalex +5 more sources
Emotional Impairment and Persistent Upregulation of mGlu5 Receptor following Morphine Abstinence: Implications of an mGlu5-MOPr Interaction. [PDF]
, 2016 BACKGROUND: A difficult problem in treating opioid addicts is the maintenance of a drug-free state because of the negative emotional symptoms associated with withdrawal, which may trigger relapse.
Bailey, A +8 more
core +1 more source