Results 81 to 90 of about 59,784 (305)

A comprehensive review on adaptive plasticity and recovery mechanisms post‐acquired brain injury

Neuroprotection, EarlyView.
This figure illustrates the dynamic process of neurogenesis following brain injury, focusing on the roles of neural stem and progenitor cells at the injury site. Key mechanisms include axonal sprouting, synaptogenesis, dendritic remodeling, and brain‐derived neurotrophic factor signaling via TrkB receptors.
Ravi Kumar Rajan
wiley   +1 more source

Blunted Cystine–Glutamate Antiporter Function in the Nucleus Accumbens Promotes Cocaine-induced Drug Seeking [PDF]

, 2008
Repeated cocaine alters glutamate neurotransmission, in part, by reducing cystine–glutamate exchange via system xc−, which maintains glutamate levels and receptor stimulation in the extrasynaptic compartment.
Abdulhameed, Omer, Baker, David A., Grier, Mark D., Kau, Kristen S., Madayag, Aric, Mantsch, John R.   +5 more
core   +1 more source

The prion protein regulates glutamate-mediated Ca2+ entry and mitochondrial Ca2+ accumulation in neurons [PDF]

, 2017
The cellular prion protein (PrPC) whose conformational misfolding leads to the production of deadly prions, has a still-unclarified cellular function despite decades of intensive research.
Bertoli, Alessandro, Castellani, Angela, Giacomello, Marta, Lim, Dmitry, Mario, Agnese De, Massimino, Maria Lina, Peggion, Caterina, Sorgato, Maria Catia, Viviani, Francesca   +8 more
core   +1 more source

Memantine Administration Enhances Glutamatergic and GABAergic Pathways in the Human Hippocampus of Alzheimer's Disease Patients

PROTEOMICS, EarlyView.
ABSTRACT One of the traditional treatments in Alzheimer's disease (AD) is administration of memantine, the NMDA receptor antagonist. However, the molecular mechanism of the complex memantine action and the impact on the hippocampal proteome in humans is unknown.
Ivo Fabrik, Rudolf Kupcik, Daniela Fabrikova, Marketa Chvojkova, Kristina Holubova, Kristina Hakenova, Martin Horak, Jiri Soukup, Monika Manethova, Robert Rusina, Radoslav Matej, Ales Ryska, Ondrej Soukup   +12 more
wiley   +1 more source

Role of Metabotropic Glutamate Receptors in Neurological Disorders

Frontiers in Molecular Neuroscience, 2019
Glutamate is a fundamental excitatory neurotransmitter in the mammalian central nervous system (CNS), playing key roles in memory, neuronal development, and synaptic plasticity.
Rosalia Crupi, Daniela Impellizzeri, Salvatore Cuzzocrea, Salvatore Cuzzocrea   +3 more
doaj   +1 more source

Exploring the pathophysiology underlying clozapine‐induced enhancement of glutamatergic transmission through L‐glutamate and D‐serine release associated with pannexin1 hemichannels

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Clozapine, an approved antipsychotic for treatment‐resistant schizophrenia (TRS), enhances glutamatergic transmission by increasing exocytosis and non‐exocytosis glutamate release; however, its full action remained to be clarified.
Motohiro Okada, Ruri Okubo, Eishi Motomura   +2 more
wiley   +1 more source

Changes in synaptic transmission and protein expression in the brains of adult offspring after prenatal inhibition of the kynurenine pathway [PDF]

, 2013
During early brain development, N-methyl-d-aspartate (NMDA) receptors are involved in cell migration, neuritogenesis, axon guidance and synapse formation, but the mechanisms which regulate NMDA receptor density and function remain unclear. The kynurenine
Ahn, Al-Hayani, Alberati-Giani, Alexander, Alexander, Alvarez, Angot, Baez, Banerjee, Beal, Breton, Broadstock, Brown, Brown, C.M. Forrest, Cai, Charytoniuk, Chess, Chess, Chess, Chiarugi, Clark, Colonnese, Copeland, Corbo, Couillard-Despres, Cozzi, Cuppini, D. Jerusalinsky, Dave, Dellovade, Dikranian, Dobbing, Dobelis, Drian, du Bois, Dykens, E. Kornisiuk, English, Erhardt, Ernst, Fagiolini, Fatemi, Fazio, Forrest, Forsythe, Friocourt, Gleeson, Gobaille, Goncalves, Guidetti, Guillemin, Guillemin, Gurdon, Harris, Harvey, Heng, Higgins, Higgins, Hilmas, Hiramatsu, Hoffman, Holtze, Hor, Hornig, Huang, Hynes, Ikonomidou, Iwasato, Jin, K. McNair, Kappeler, Kemp, Kerjan, L.G. Darlington, Larson, Leung, M. Pisar, M. Snitcofsky, Martel, Meyer, Miller, Mok, Munn, Myers, N. Gonzalez, Nacher, Nathan, Neale, Neher, Nilsson, Niswender, O.S. Khalil, Okuda, Otis, Ozaki, O’Kane, Palma, Parish, Pena, Perkins, Pfaffl, Pocivavsek, Potter, Prajerova, Rajan, Ramakers, Ramoa, Rodgers, Rosenmund, Röver, Saito, Saviane, Schwarcz, Schwarcz, Shin, Simon, Sims, Spassky, Stone, Stone, Stone, Stone, Stone, Stringer, T.W. Stone, Taleb, Tang, Traiffort, Traiffort, Traiffort, Traynelis, Udin, Ultanir, Vaillant, Vincent, Waldeck, Walker, Wang, Wang, Wierońska, Wu, Xiong, Zucker, Zuckerman   +144 more
core   +2 more sources

Performance of cryptogenic new onset refractory status epilepticus score in a Brazilian cohort after testing for antineuronal antibodies with tissue‐based and cell‐based assays

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to describe a case series of Brazilian new onset refractory status epilepticus (NORSE) patients and evaluate the sensitivity and specificity of a clinical score to predict cryptogenic etiology (c‐NORSE score) after autoimmune encephalitis (AE) testing.
João Henrique Fregadolli Ferreira, Anna Maria Gomes, Ana Carolina Zetehaku, Taissa Ferrari Marinho, Fabio Fieni Toso, Caio César Diniz Disserol, Mariana Braatz Krueger, Mara Lúcia Schmitz Ferreira Santos, Aline Freire Borges Juliano, Tércio Luz Barbosa, Letícia Januzi de Almeida Rocha, Fernando Tenório Gameleira, Renata Barbosa Paolilo, Vanessa Daccach, João Pedro Izidoro Gomes, Katia Lin, Adaucto Wanderley da Nóbrega Jr., Emily Lima Marmentini, Eduardo Ferracioli Fusão, Anderson de Cuffa, Georgia Lelis Aranha Tavares, Ronaldo Maciel Dias, Sabrina Stephanie Lana Diniz, Fábio Siquineli, Pedro Braga‐Neto, Paulo Ribeiro Nobrega, Lorena Pitombeira Sanders, Fernanda Martins Maia Carvalho, Renata Brasileiro Reis Pereira, Eduardo Sousa de Melo, Adélia Maria de Miranda Henriques‐Souza, Clecio de Oliveira Godeiro Jr., Omar Gurrola Arambula, Filipe Nolasco de Souza e Silva, Karla Oliveira Couto, Dayane Danieli, Katia Werneck Seitz, Alessandra Dellavance, Verena Endmayr, Romana Höftberger, Luis Eduardo Coelho Andrade, Luis Otavio Caboclo, Livia Almeida Dutra   +42 more
wiley   +1 more source

A PI3K-mediated negative feedback regulates Drosophila motor neuron excitability [PDF]

, 2008
Negative feedback can act as a homeostatic mechanism to maintain neuronal activity at a particular specified value. At the Drosophila neuromuscular junction, a mutation in the type II metabotropic glutamate receptor gene (mGluRA) increased motor neuron ...
Curtis C. J. Lin, Eric Howlett, Michael Stern, William Lavery   +3 more
core   +1 more source

Clioquinol as a new therapy in epilepsy: From preclinical evidence to a proof‐of‐concept clinical study

Epilepsia, EarlyView.
Abstract Objective Drug‐resistant epilepsy (DRE) affects >25 million people worldwide and is often associated with neuroinflammation. Increasing evidence links deficiency or malfunctioning of the enzyme phosphoglycerate dehydrogenase (PHGDH), which converts 3‐phosphoglycerate to generate serine and the neurotransmitter glycine, with (drug‐resistant ...
Karin Thevissen, Annelii Ny, Daniëlle Copmans, Jana Tits, Kenichi Kamata, Eva Gielis, Kevin Longin, Jo Sourbron, Peravina Thergarajan, Tracie Huey‐Lin Tan, Idrish Ali, Nigel C. Jones, Terence J. O'Brien, Mastura Monif, Bridgette D. Semple, Christine Germeys, Benedetta Frizzi, Virginia Minniti, Sebastian Perrone, Carole L. Linster, Ilaria Elia, Ludo Van Den Bosch, Bruno P. A. Cammue, Arnout Voet, Lieven Lagae, Peter de Witte   +25 more
wiley   +1 more source