ABSTRACT Kaposi's sarcoma‐associated herpesvirus (KSHV) is a human double‐stranded DNA virus that is responsible for the development of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), multicentric Castleman's disease (MCD), and KSHV inflammatory cytokine syndrome (KICS).
Quanyuan Wan, Andrew J. Tucker, Jun Zhao
wiley +1 more source
Multiple presynaptic metabotropic glutamate receptors modulate excitatory and inhibitory synaptic transmission in hippocampal area CA1 [PDF]
RW Gereau, P. Jeffrey Conn
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Astrocyte in Neurological Disease: Pathogenesis and Therapy
This review provides comprehensive overview of astrocytes in neurological disorders. Astrocytes contribute to neurological disorders via A1/A2 polarization, inducing neuroinflammation, synaptic, and BBB dysfunction. Metabolic disturbances in glucose, lipid, and amino acid pathways leading to oxidative stress and mitochondrial damage.
Meihui Huang+4 more
wiley +1 more source
Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1 [PDF]
C. Joly+5 more
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Molecular Mechanisms of Chronic Pain and Therapeutic Interventions
We offer a comprehensive overview of the distinctive molecular mechanisms underlying nociceptive, neuropathic, and nociplastic pain, including the immune responses, ion channels, monoaminergic imbalance, and neuroinflammation. Subsequently, we summarized the status quo of nociceptive, neuropathic, and nociplastic pain managementmanipulation.
Zhen Li+8 more
wiley +1 more source
Functional Switch from Facilitation to Inhibition in the Control of Glutamate Release by Metabotropic Glutamate Receptors [PDF]
I. Herrero+2 more
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Abstract Background Fatigue in Parkinson's disease (PD) is a prevalent and debilitating non‐motor symptom. Despite its significant impact on quality of life, the underlying neurochemical and network‐based mechanisms remain poorly understood. Objectives This observational study applied a multimodal imaging approach to explore potential links between the
Ilaria Antonella Di Vico+14 more
wiley +1 more source
EpileptogenesisIn VivoEnhances the Sensitivity of Inhibitory Presynaptic Metabotropic Glutamate Receptors in Basolateral Amygdala NeuronsIn Vitro [PDF]
Volker Neugebauer+2 more
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Elevated glycogen synthase kinase 3 activity in Fragile X mice: key metabolic regulator with evidence for treatment potential [PDF]
Significant advances have been made in understanding the underlying defects of and developing potential treatments for Fragile X Syndrome (FXS), the most common heritable mental retardation.
Bauchwitz, Dr. Robert P.
core
Metabotropic glutamate receptors trigger postsynaptic protein synthesis.
Ivan Jeanne Weiler, William T. Greenough
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